Circadian Control of the NAD + Salvage Pathway by CLOCK-SIRT1

American Association for the Advancement of Science (AAAS) - Tập 324 Số 5927 - Trang 654-657 - 2009
Yasukazu Nakahata1, Saurabh Sahar1, Giuseppe Astarita1, Milota Kaluzová1, Paolo Sassone‐Corsi1
1Department of Pharmacology, School of Medicine, University of California, Irvine, Irvine, CA 92697, USA.

Tóm tắt

Circadian Oscillations The 24-hour day-night cycle plays an important role in mammalian physiology and behavior and, as most travelers are well aware, there is an intimate link between our in-built circadian clocks and metabolic rhythms. This link is in part forged by the protein deacetylase SIRT1, which regulates the clock's molecular circuitry. SIRT1 uses as a cofactor the cellular metabolite NAD + , which is synthesized through a salvage pathway that includes the enzyme nicotinamide phosphoribosyltransferase (NAMPT) (see the Perspective by Wijnen ). Ramsey et al. (p. 651 ; published online 19 March) and Nakahata et al. (p. 654 , published online 12 March) now show that NAMPT and NAD + levels oscillate during the daily 24-hour cycle and that this oscillation is regulated by the circadian clock. Furthermore, the oscillations in NAD + modulate the activity of SIRT1 feeding back into the circadian clock.

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Thông tin xuất bản

American Association for the Advancement of Science (AAAS)

Tập 324 Số 5927

654-657

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