Chronic hepatitis C virus infection triggers spontaneous differential expression of biosignatures associated with T cell exhaustion and apoptosis signaling in peripheral blood mononucleocytes

Muttiah Barathan1, Kaliappan Gopal2, Rosmawati Mohamed3, Rada Ellegård4, Alireza Saeidi1, Jamuna Vadivelu1, Abdul Wahid Ansari5, Hussin A. Rothan6, M. Ravishankar Ram1, Keivan Zandi1, Li Chang1, Ramachandran Vignesh7, F. Karlhans8, Adeeba Kamarulzaman5, V. Vijayakumar9, Marie Larsson4, Tunku Kamarul2, Esaki M. Shankar5
1Tropical Infectious Disease Research and Education Center (TIDREC), Department of Medical Microbiology, Faculty of Medicine, University of Malaya, Lembah Pantai, 50603, Kuala Lumpur, Malaysia
2National Orthopedics Center for Excellence in Research and Learning (NOCERAL), Department of Orthopedics surgery, Tissue engineering group (TEG), Faculty of Medicine, University of Malaya, Lembah Pantai, 50603, Kuala Lumpur, Malaysia
3Department of Medicine, University of Malaya, Lembah Pantai, 50603, Kuala Lumpur, Malaysia
4Division of Molecular Virology, Department of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden
5Center for of Excellence for Research in AIDS (CERiA), University of Malaya, Lembah Pantai, 50603, Kuala Lumpur, Malaysia
6Department of Molecular Medicine, University of Malaya, Lembah Pantai, 50603, Kuala Lumpur, Malaysia
7YRG Center for AIDS Research and Education, Voluntary Health Services Hospital Campus, Taramani, Chennai, 600113, India
8Unit for Lung and Airway Research, Division of Physiology, Institute for Environmental Medicine, Karolinska Institute, Solna, Stockholm, Sweden
9Department of Microbiology and Immunology, Emory Vaccine Center, Atlanta, USA

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