Chromium(III) release from chromium‐tanned leather elicits allergic contact dermatitis: a use test study

Contact Dermatitis - Tập 78 Số 5 - Trang 307-314 - 2018
Yolanda Hedberg1,2, Behnaz Erfani2, Mihály Matura2,3, Carola Lidén2
1Department of Chemistry and Division of Surface and Corrosion Science, KTH Royal Institute of Technology, School of Chemical Science and Engineering, 100 44 Stockholm, Sweden
2Institute of Environmental Medicine, Karolinska Institute, 171 77 Stockholm, Sweden
3Unit of Occupational and Environmental Dermatology, Centre for Occupational and Environmental Medicine, Stockholm County Council, 171 76 Stockholm, Sweden

Tóm tắt

SummaryBackgroundChromium (Cr) is a common skin sensitizer. The use of Cr(VI) in leather is restricted in the EU, but that of Cr(III) is not.ObjectivesTo assess whether prolonged exposure to Cr‐tanned leather with mainly Cr(III) release may elicit allergic contact dermatitis in Cr‐allergic individuals.MethodTen Cr‐allergic subjects and 22 controls were patch tested with serial dilutions of Cr(III) and Cr(VI), and with leather samples. They then conducted a use test with a Cr‐tanned and a Cr‐free leather bracelet over a period of 3 weeks, for 12 h per day. Cr deposited on the skin from the bracelets was measured in the controls, and the diphenylcarbazide test for Cr(VI) and extraction tests for Cr(III) and Cr(VI) were conducted for the different leathers.ResultsFour of 10 Cr‐allergic subjects developed positive reactions to the Cr‐tanned bracelet within 7–21 days, whereas only 1 of 10 had a positive patch test reaction to this leather. Cr released from the Cr‐tanned leather was most probably entirely Cr(III), with a quantifiable amount being deposited on the skin.ConclusionsThis study strongly suggests that prolonged and repeated exposure to Cr‐tanned leather with mainly Cr(III) release is capable of eliciting allergic contact dermatitis in Cr‐allergic individuals.

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Contact Dermatitis

Tập 78 Số 5

307-314

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