Sự trao đổi được điều chỉnh bởi chromatin giữa các phức hợp polycomb ức chế 2 (PRC2)-Ezh2 và PRC2-Ezh1 kiểm soát sự kích hoạt myogenin trong tế bào cơ xương
Tóm tắt
Các gen nhóm polycomb (PcG) mã hóa cho các phức hợp đa protein chromatin có trách nhiệm duy trì trạng thái im lặng của các chương trình phiên mã trong quá trình biệt hóa và ở các mô trưởng thành. Mặc dù có một lượng lớn thông tin về chức năng của PcG trong quá trình phát triển và duy trì bản sắc tế bào, nhưng vẫn ít thông tin được biết đến về động học của các phức hợp PcG và vai trò của chúng trong quá trình biệt hóa cuối cùng.
Chúng tôi cho thấy rằng hai phức hợp polycomb ức chế (PRC)2 khác nhau có sự đóng góp vào quá trình biệt hóa tế bào cơ vân: phức hợp PRC2-Ezh2, phức hợp này gắn với trình tự khởi động
Từ khóa
Tài liệu tham khảo
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