Cholestasis induces reversible accumulation of periplakin in mouse liver

BMC Gastroenterology - Tập 13 - Trang 1-17 - 2013
Shinji Ito1, Junko Satoh1, Tsutomu Matsubara2, Yatrik M Shah3, Sung-hoon Ahn4, Cherie R Anderson5, Weiwei Shan6, Jeffrey M Peters5, Frank J Gonzalez7
1Biofrontier Platform, Graduate School of Medicine, Kyoto University, Kyoto, Japan
2Department of Anatomy and Regenerative Biology, Graduate School of Medicine, Osaka City University, Osaka, Japan
3Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, USA
4Drug Discovery Platform Technology Team, Korea Research Institute of Chemical Technology, Yoosung, South Korea
5Department of Veterinary and Biomedical Sciences and the Center for Molecular Toxicology and Carcinogenesis, Pennsylvania State University, University Park, USA
6Department of Pathology, University of Texas MD Anderson Cancer Center, Houston, USA;
7Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, USA

Tóm tắt

Periplakin (PPL) is a rod-shaped cytolinker protein thought to connect cellular adhesion junctional complexes to cytoskeletal filaments. PPL serves as a structural component of the cornified envelope in the skin and interacts with various types of proteins in cultured cells; its level decreases dramatically during tumorigenic progression in human epithelial tissues. Despite these intriguing observations, the physiological roles of PPL, especially in non-cutaneous tissues, are still largely unknown. Because we observed a marked fluctuation of PPL expression in mouse liver in association with the bile acid receptor farnesoid X receptor (FXR) and cholestasis, we sought to characterize the role of PPL in the liver and determine its contributions to the etiology and pathogenesis of cholestasis. Time- and context-dependent expression of PPL in various mouse models of hepatic and renal disorders were examined by immunohistochemistry, western blotting, and quantitative real-time polymerase chain reactions. The hepatic expression of PPL was significantly decreased in Fxr −/− mice. In contrast, the expression was dramatically increased during cholestasis, with massive PPL accumulation observed at the boundaries of hepatocytes in wild-type mice. Interestingly, the hepatic accumulation of PPL resulting from cholestasis was reversible. In addition, similar accumulation of PPL at cellular boundaries was found in epithelial cells around renal tubules upon ureteral obstruction. PPL may be involved in the temporal accommodation to fluid stasis in different tissues. Further examination of the roles for PPL may lead to the discovery of a novel mechanism for cellular protection by cytolinkers that is applicable to many tissues and in many contexts.

Tài liệu tham khảo

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