Chewing gum reduces postoperative ileus following abdominal surgery: A meta‐analysis of 17 randomized controlled trials

Journal of Gastroenterology and Hepatology (Australia) - Tập 28 Số 7 - Trang 1122-1132 - 2013
Shan Li1, Yanqiong Liu1, Qiliu Peng1, Li Xie1, Jian Wang1, Xue Qin1
1Department of Clinical Laboratory, First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region, China

Tóm tắt

AbstractBackground and AimChewing gum proposal has been used in surgery to reduce postoperative ileus for more than 10 years; however, the efficacy remains imprecise. The aim of this study was to accurately assess whether the use of the chewing gum could reduce duration of postoperative ileus following the abdominal surgery.MethodsA systematic review was conducted in Medline, EMBASE, and the Cochrane Library through December 2012 to identify randomized controlled trials comparing with and without the use of chewing gum in patients undergoing abdominal surgery. The outcome of interest was time to flatus, time to bowel movement, and length of stay. Subgroup analyses were performed to examine the impact of different studies structural design. Cumulative meta‐analyses were used to examine how the evidence has changed over time.ResultsSeventeen randomized controlled trials involving 1374 participants were included. Overall time (in days) for the patients to pass flatus (weighted mean difference [WMD], −0.31; 95% confidence interval [CI], −0.43 to −0.19; P = 0.000); time to bowel movement (WMD, −0.51; 95% CI, −0.73 to −0.29; P = 0.000); and length of stay (WMD, −0.72; 95% CI, −1.02 to −0.43; P = 0.000) were significantly reduced in the treatment group. However, both of these results demonstrated significant heterogeneity. No evidence of publication bias was observed. Cumulative meta‐analysis showed that chewing gum reduces duration of postoperative ileus that has been available for over 6 years.ConclusionsResults of the meta‐analysis suggest that chewing gum following abdominal surgery offers benefits in reducing the time of postoperative ileus.

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Tài liệu tham khảo

10.1007/s00268-005-0613-9

10.1097/MJT.0b013e31804c6f37

10.1053/cgh.2003.50012

10.1111/j.1743-3150.2004.00559.x

10.1046/j.1365-2168.2000.01595.x

10.1016/S0002-9610(01)00781-4

10.1016/j.suc.2012.01.010

10.2147/TCRM.S3147

10.1001/archsurg.141.3.307

10.3109/00365528909092239

10.1007/BF01300279

10.1016/S1072-7515(02)01179-1

Hirayama I, 2006, Gum‐chewing stimulates bowel motility after surgery for colorectal cancer, Hepatogastroenterology, 53, 206

10.1001/archsurg.141.2.174

10.1016/j.urology.2007.07.048

10.1055/s-2007-989273

10.1111/j.1471-0528.2009.02225.x

10.1159/000260048

10.1080/00015458.2010.11680596

10.1055/s-0029-1243313

Bahena‐Aponte JA, 2010, Usefulness of chewing gum for the resolution of postoperative ileus in left colon resections., Rev. Gastroenterol. Mex., 75, 369

10.1016/j.urology.2010.06.042

10.17305/bjbms.2012.2452

Marwah S, 2012, Role of gum chewing on the duration of postoperative ileus following ileostomy closure done for typhoid ileal perforation: a prospective randomized trial. Saudi, J. Gastroenterol., 18, 111

10.1007/s00595-012-0180-2

10.1016/j.jamcollsurg.2005.06.152

10.1016/j.jamcollsurg.2006.02.009

10.1111/j.1463-1318.2005.00884.x

10.1159/000095947

10.1055/s-0029-1202776

Crainic C, 2009, Comparison of methods to facilitate postoperative bowel function, Medsurg Nurs., 18, 235

Smith SR, 2010, Effect of gum chewing on gastrointestinal recovery after laparoscopic colorectal resectional surgery: a prospective randomized clinical trial [Abstract], ANZ J. Surg., 80, A17

10.1007/s10350-007-9039-9

10.1159/000117822

10.1001/archsurg.143.8.788

10.1016/j.ijsu.2009.01.006

10.1007/s00268-009-0104-5

10.1016/S0140-6736(99)04149-5

10.1136/bmj.d5928

10.1136/bmj.323.7305.157

10.1002/sim.1186

10.1002/sim.1186

10.1016/0197-2456(86)90046-2

Mantel N, 1959, Statistical aspects of the analysis of data from retrospective studies of disease, J. Natl Cancer Inst., 22, 719

10.2307/2533446

10.1136/bmj.315.7109.629

Watson H, 2008, Does chewing (gum) aid recovery after bowel resection? A randomized controlled trial (RCT), Colorectal Dis., 10, 6

10.1007/BF01536327

10.1136/gut.45.2008.ii17

10.1007/BF02237245

Burgdorf SK, 2012, Short hospital stay after laparoscopic colorectal surgery without fast track, Minim. Invasive Surg., 2012, 260

10.1097/DCR.0b013e31824bd31e

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Journal of Gastroenterology and Hepatology (Australia)

Tập 28 Số 7

1122-1132

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