Hóa trị được thực hiện kết hợp với việc sửa đổi rào chắn máu-não bằng phương pháp thẩm thấu trong bệnh nhân có di căn não

Journal of Neuro-Oncology - Tập 4 - Trang 195-207 - 1987
Edward A Neuwelt1,2, Suellen A Dahlborg1
1Department of Neurosurgery, The Oregon Health Sciences University, Portland, USA
2Division of Neurosurgery - L472, The Oregon Health Sciences University, Portland, USA

Tóm tắt

Kinh nghiệm lâm sàng của bảy bệnh nhân mắc các bệnh u ác tính hệ thống (ung thư vú, phổi và tinh hoàn) với di căn đến hệ thần kinh trung ương được điều trị bằng hóa trị kết hợp với sửa đổi rào chắn máu-não đảo ngược được xem xét. Một phác đồ hóa trị phối hợp bao gồm metotrexate nội mạch, cytoxan tĩnh mạch và procarbazine uống trong cùng với các infusions mannitol nội mạch đã được thực hiện thành công với độc tính tối thiểu. Kết quả ở những bệnh nhân này cho thấy một số hiệu quả điều trị đối với lượng thuốc tăng cường đạt được bằng kỹ thuật này. Mặc dù có tính gợi mở, các nghiên cứu bổ sung sẽ được yêu cầu để xác nhận rằng việc sửa đổi rào chắn là một tham số quan trọng trong hiệu quả như vậy.

Từ khóa

#hóa trị #rào chắn máu-não #di căn não #liệu pháp điều trị #độc tính tối thiểu

Tài liệu tham khảo

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