Chemosensory irritations and pulmonary effects of acute exposure to emissions from oriented strand board

Human and Experimental Toxicology - Tập 30 Số 9 - Trang 1204-1221 - 2011
Richard Gminski1, R. Marutzky2, Sebastian Kevekordes3, Frank Fuhrmann2, Werner Bürger2, Dieter Hauschke4, Winfried Ebner3, Volker Mersch‐Sundermann3
1Department of Environmental Health Sciences, University Medical Center Freiburg, Freiburg, Germany
2Fraunhofer Institute for Wood-Research–Wilhelm-Klauditz-Institut (WKI), Braunschweig, Germany
3#N# 1Department of Environmental Health Sciences, University Medical Center Freiburg, Freiburg, Germany
4#N# 3Institute of Biostatistics and Medical Informatics, University Medical Center Freiburg, Germany

Tóm tắt

Due to the reduction of air change rates in low-energy houses, the contribution to indoor air quality of volatile organic compounds (VOCs) emitting from oriented strand boards (OSB) has become increasingly important. The aim of this study was to evaluate sensory irritations, pulmonary effects and odor annoyance of emissions from OSB in healthy human volunteers compared to clean air. Twenty-four healthy non-smokers were exposed to clean air and OSB emissions for 2 h under controlled conditions in a 48 m3 test chamber at three different time points: to fresh OSB panels and to the same panels after open storage for 2 and 8 weeks. Chemosensory irritation, exhaled nitric oxide (NO) concentration, eye blink frequency, lung function and subjective perception of irritation of eyes, nose and throat were examined before, during and after exposure. Additionally, olfactory perception was investigated. Total VOC exposure concentrations reached 8.9 ± 0.8 mg/m3 for the fresh OSB panels. Emissions consisted predominantly of α-pinene, ▵3-carene and hexanal. Two-hour exposure to high VOC concentrations revealed no irritating or pulmonary effects. All the subjective ratings of discomfort were at a low level and the medians did not exceed the expression ‘hardly at all.’ Only the ratings for smell of emissions increased significantly during exposure in comparison to clean air. In conclusion, exposure of healthy volunteers to OSB emissions did not elicit sensory irritations or pulmonary effects up to a VOC concentration of about 9 mg/m3. Sensory intensity of OSB emissions in the chamber air was rated as ‘neutral to pleasant.’

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Tài liệu tham khảo

Barry A, Indoor Air 99, Proceedings of the 8th International Conference on Indoor Air Quality and Climate 1999, 5, 129

10.1515/HF.1999.073

Baumann M, 1999, For Prod J, 49, 49

Baumann M, 2000, For Prod J, 50, 75

10.1515/HF.2005.086

Ohlmeyer M, Bundesforschungsansalt für Forst- und Holzwirtschaft Hamburg

Saltharnmer T, Proceedings of Healthy Buildings, 2003, 160

10.1016/S1352-2310(97)00219-7

10.1034/j.1600-0668.2000.010004269.x

10.5271/sjweh.1033

10.5271/sjweh.1771

10.1016/S0041-008X(05)80002-X

Kasanen JP, 1999, J Toxicol Environ Health Part A, 56, 89

Mersch-Sundermann V, 2007, Umweltmed Forsch Praxis, 12, 129

10.1111/j.1600-0668.2005.00393.x

10.1080/10408440490269586

Edman K, 2003, Ann Occup Hyg, 47, 219

10.1007/BF00377751

Ernstgard L, 2006, J Occup Environ Health, 48, 573

National Toxicology Program (NTP Draft), 2006, Study number SRL-13 wk 03AP/M and SRL-13 wk 03AP/R

10.1034/j.1600-0668.2000.010003178.x

10.1111/j.1600-0668.2004.00315.x

10.1111/j.1600-0668.1995.00005.x

10.1037/0278-6133.18.6.579

Fahrenberg J, Hampel R, Selg H. Freiburger Persönlichkeitsinventar (FPI). Revidierte Fassung (FPI-R) und teilweise geänderte Fassung (FPI-A1), 7. Auflage, 2001; Hogrefe, Göttingen.

Fahrenberg J, Myrtek M, Schumacher J, Brähler E. Fragebogen zur Lebenszufriedenheit F L Z, 2000; Hogrefe, Göttingen.

10.1007/s00405-006-0173-0

10.1097/01.mlg.0000246518.79894.7e

Kobal G, 1996, Rhinology, 34, 222

ISO 16000-9, 2006, International Organization for Standardization

EN 717-1. Wood-based panels–Determination of formaldehyde release–Part 1: formaldehyde emission by the chamber method, 2005.

ISO 16000-6, 2004, International Organization for Standardization

ISO 16000-3, 2001, International Organization for Standardization

10.1164/rccm.200406-710ST

10.1007/s10877-005-1158-z

10.1016/j.etap.2004.12.056

10.1016/j.toxlet.2006.01.010

Ernstgard L, 2008, J Appl Toxicol, 9, 263

GIRL. Feststellung und Beurteilung von Geruchsimmissionen (Geruchsimmissions-Richtlinie–GIRL–) in der Fassung vom 21. September 2004 mit Begründung und Auslegungshinweisen, 2004 (in German).

Hollander M, 1973, Nonparametric statistical methods

10.1080/01621459.1963.10500843

10.1136/oem.53.2.100

Gminski R, Marutzky R, Kevekordes S, Sensory irritations and pulmonary effects in human volunteers following short-term exposure to pinewood emissions, in prep.

10.5271/sjweh.1771

10.1002/ajim.4700230512

10.1034/j.1600-0668.2000.010004315.x

10.1080/15287399309531702

10.1080/10473289.2003.10466190

10.1378/chest.06-2531

10.1183/09031936.95.08020295

10.1007/s00011-006-6111-1

10.1111/j.1398-9995.2008.01855.x

10.2174/138955707780619635

10.1016/j.jaci.2006.03.018

10.1007/s00420-003-0502-1

10.1016/j.toxlet.2004.11.013

van Thriel C, 2003, Toxicol Lett, 140

10.1016/S1382-6689(03)00047-4

10.5271/sjweh.716

10.5271/sjweh.748

10.1136/oem.59.11.759

10.1006/enrs.1993.1132

10.1006/taap.1996.0223

10.5271/sjweh.800

10.1111/j.1600-0668.2006.00441.x

10.1164/ajrccm.161.5.9905061

10.1080/00039890109604069

10.1093/occmed/kqh082

10.1183/09031936.03.00066903a

10.1164/rccm.200810-1604ED

10.1289/ehp.8193

10.1016/j.toxlet.2008.07.013

10.1007/s00420-007-0264-2

10.1016/j.yrtph.2007.08.012

10.1289/ehp.011091045

10.1016/S0892-8967(00)00033-X

10.1006/exer.1998.0656

10.1007/s00420-005-0058-3

10.1080/00039896.1992.9935948

10.1111/j.1600-0668.2007.00476.x

10.1016/j.atmosenv.2009.02.024

Nagata Y, 2003, J Jpn Air Cleaning Assoc, 41, 17

10.1093/chemse/bjm016

Devos M, Patte F, Rouault J, Standardized human olfactory thresholds. Oxford: IRL Press at Oxford University Press, 1990, p.1–165.

10.1016/j.buildenv.2006.05.009

10.1111/j.1600-0668.2006.00462.x

10.1093/chemse/23.1.31

Dalton P, 2003, Toxicol Lett, 140

10.1016/j.toxlet.2010.03.015

10.1007/s00420-003-0459-0

10.1111/j.1600-0668.2009.00596.x

10.1021/es050228s

10.1021/es990445r

10.1034/j.1600-0668.2000.010002082.x

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Human and Experimental Toxicology

Tập 30 Số 9

1204-1221

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