Chemistry and biology of Phellinus linteus

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isolated from fruit bodies of wild Phellinus linteus, Chem Pharm Bull, 56, 173, 10.1248/cpb.56.173 Yang, 2008, Antagonizing TGF-β induced liver fibrosis by a retinoic acid derivative through regulation of ROS and calcium influx, Biochem Biophys Res Comm, 365, 484, 10.1016/j.bbrc.2007.10.203 Yeo, 2007, Phellinone, a new furanone derivative from the Phellinus linteus KT&G PL-2, Arch Pharm Res, 30, 924, 10.1007/BF02993957 Kang, 2004, A sphingolipid and tryrosinase inhibitors from the fruiting body of Phellinus linteus, Arch Pharm Res, 27, 742, 10.1007/BF02980143 Lu, 2009, Hispolon from Phellinus linteus has antiproliferative effects via MDM2-recruited ERK1/2 activity in breast and bladder cancer cells, Food Chem Toxicol, 47, 2013, 10.1016/j.fct.2009.05.023 Huang, 2010, Hispolon suppresses SK-Hep1 human hepatoma cell metastasis by inhibiting matrix metalloproteinase-2/9 and urokinase-plasminogen activator through the PI3K/Akt and ERK signaling pathways, J Agric Food Chem, 58, 9468, 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activity of polysaccharide isolated from Phellinus linteus in non-obese diabetic mouse, Int Immnunopharmacol, 10, 72, 10.1016/j.intimp.2009.09.024 Choi, 2004, Improvement of insulin resistance in insulin secretion by water extracts of Cordyceps militaris, Phellinus linteus, and Paecilomyces tenuipes in 90% pancreatectomized rats, Biosci Biotechnol Biochem, 68, 2257, 10.1271/bbb.68.2257 Kim, 2004, Anti-inflammatory and related pharmacological activities of the n-BuOH subfraction of mushroom Phellinus linteus, J Ethnopharmacol, 93, 141, 10.1016/j.jep.2004.03.048 Kim, 2006, Heme oxygenase-1 mediates the anti-inflammatory effect of mushroom Phellinus linteus in LPS-stimulated RAW264.7 macrophages, J Ethnopharmacol, 106, 364, 10.1016/j.jep.2006.01.009 Kim, 2007, The anti-inflammatory activity of Phellinus linteus (Berk. &M.A. Curt.) is mediated through the PKCδ/Nrf2/ARE signaling to up-regulation of heme oxygenase-1, J Ethnopharmacol, 113, 240, 10.1016/j.jep.2007.05.032 Kim, 2007, Phellinus 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polysaccharides and carboxymethylcellulose combination to prevent intraperitoneal adhesion and abscess formation in a rat peritonitis model, J Vet Med Sci, 66, 1205, 10.1292/jvms.66.1205 Park, 2003, Acidic polysaccharides isolated from Phellinus linteus induce phenotypic and functional maturation of murine dendritic cells, Biochem Biophys Res Commun, 312, 449, 10.1016/j.bbrc.2003.10.136 Kim, 2004, Acidic polysaccharide isolated from Phellinus linteus enhances through the up-regulation of nitric oxide and tumor necrosis factor-α from peritoneal macrophages, J Ethnopharmacol, 95, 69, 10.1016/j.jep.2004.06.024 Kim, 2003, Proteoglycan isolated from Phellinus linteus activates murine B lymphocytes via protein kinase C and protein tyrosin kinase, Int Immunopharmacol, 3, 1281, 10.1016/S1567-5769(03)00115-2 Kim, 2004, Proteoglycan isolated from Phellinus linteus inhibits tumor growth through mechanisms leading to an activation of CD11c+CD8+DC and type I helper T cell-dominant immune state, FEBS Lett, 576, 391, 10.1016/j.febslet.2004.09.047 Kim, 2004, Proteoglycan isolated from Phellinus linteus induces toll-like receptors 2- and 4-mediated maturation of murine dendritic cells via activation of ERK, p38, and NFκB, Biol Pharm Bull, 27, 1656, 10.1248/bpb.27.1656 Huang, 2011, Orally administered mycelial culture of Phellinus linteus exhibits antitumor effects in hepatoma cell-bearing mice, J Ethnopharmacol, 133, 460, 10.1016/j.jep.2010.10.015 Li, 2011, Anti-tumor effects of proteoglycan from Phellinus lintenus by immunomodulating and inhibiting Reg IV/EGFR/Akt signaling pathway in colorectal carvinoma, Int J Bio Macromol, 48, 511, 10.1016/j.ijbiomac.2011.01.014 Collins, 2006, Phellinus linteus sensitises apoptosis induced by doxorebisin in prostate cancer, Br J Cancer, 95, 282, 10.1038/sj.bjc.6603277 Zhu, 2007, Phellinus linteus activates different pathways to induce apoptosis in prostate cancer cells, Br J Cancer, 96, 583, 10.1038/sj.bjc.6603595 Tsuji, 2010, Phellinus linteus extract sensitizes advanced prostate cancer cells to apoptosis in athymic nude mice, PLoS One, 5, e9885, 10.1371/journal.pone.0009885 Park, 2010, The ethylacetate extract of Phellinus linteus grown on germinated brown rice induces G0/G1 cell cycle arrest and apoptosis in human colon carcinoma HT-29 cells, Phytother Res, 24, 1019, 10.1002/ptr.3064 Li, 2004, Protein-bound polysaccharides from Phellinus linteus induces G2/M phase arrest and apoptosis in SW480 human colon cancer cells, Cancer Lett, 216, 175, 10.1016/j.canlet.2004.07.014 Park, 2010, The ethyl acetate extract of PGP (Phellinus linteus grown on Panax ginseng) suppresses B16F10 melanoma cell proliferation through inducing cellular differentiation and apoptosis, J Ethnopharmacol, 132, 115, 10.1016/j.jep.2010.07.052 Chen, 2006, The apoptosis effect of hispolon from Phellinus linteus (Berkeley & Curtis) Teng on human epidermoid KB cells, J Ethnopharmacol, 105, 280, 10.1016/j.jep.2006.01.026 Guo, 2007, Modulation of lung cancer growth arrest and apoptosis by Phellinus linteus, Mol Carcinogen, 46, 144, 10.1002/mc.20275 Sliva, 2008, Phellinus linteus suppresses growth, angiogenesis and invasive behavior of breast cancer cells through the inhibition of AKT signaling, Br J Cancer, 98, 1348, 10.1038/sj.bjc.6604319 Han, 2006, Acidic polysaccharide from Phellinus linteus inhibits melanoma cell metastasis by blocking cell adhesion and invasion, Int Immunopharmacol, 6, 697, 10.1016/j.intimp.2005.10.003 Shon, 2001, Antimutagenicity and induction of anticarcinogenic phase II enzymes by basidiomycetes, J Ethnopharmacol, 77, 103, 10.1016/S0378-8741(01)00276-8 Song, 2003, Anti-angiogenic, antioxidant and xanthine oxidase inhibition activities of the mushroom Phellinus linteus, J Ethnopharmacol, 88, 113, 10.1016/S0378-8741(03)00178-8 Lim, 2004, Comparative study on the modulation of IgE and cytokine production by Phellinus linteus grown on germinated brown rice, Phellinus linteus and germinated brown rice in murine splenocytes, Biosci Biotechnol Biochem, 68, 2391, 10.1271/bbb.68.2391 Lim, 2005, Phellinus linteus grown on germinated brown rice suppresses IgE production by the modulation of Th1/Th2 balance in murine mesenteric lymph node lymphocytes, Biotechnol Lett, 27, 613, 10.1007/s10529-005-4474-y Inagaki, 2005, Inhibition of IgE-dependent mouse triphasic cutaneous reaction by a boiling water fraction separated from mycelium of Phellinus linteus, Evid Based Complement Alternat Med, 2, 369, 10.1093/ecam/neh105 Choi, 2006, Inhibition of anaphylaxis-like reaction and mast cell activation by water extract from the fruiting body of Phellinus linteus, Biol Pharm Bull, 29, 1360, 10.1248/bpb.29.1360 Matsuba, 2008, Phellinus linteus extract augments the immune response in mitomycin C-induced immunodeficient mice, Evid Based Complement Alternat Med, 5, 85, 10.1093/ecam/nem001 Harikrishnan, 2011, Diet enriched with mushroom Phellius linteus extract enhances the growth, innate immune response, and disease resistance of kelp grouper, Epinephelus bruneus against vibriosis, Fish Shellfish Immunol, 30, 128, 10.1016/j.fsi.2010.09.013 Shon, 2003, Inhibition of cytochrome P450 isozymes in rat liver microsomes by polysaccharides derived from Phellinus linteus, Biotechnol Lett, 25, 167, 10.1023/A:1021935922722 Jeon, 2003, Extracts of Phellinus linteus grown on germinated brown rice suppress liver damage induced by carbon tetrachloride in rats, Biotechnol Lett, 25, 2093, 10.1023/B:BILE.0000007071.28105.c1 Lim, 2004, Mycelial culture of Phellinus linteus protects primary cultured rat hepatocytes against hepatotoxins, J Ethnopharmacol, 95, 367, 10.1016/j.jep.2004.08.007 Ye, 2007, Protective effects of Phellinus linteus extract against iron overload-mediated oxidative stress in cultured rat hepatocytes, Phytother Res, 21, 948, 10.1002/ptr.2182 Hur, 2004, Antibacterial effect of Phellinus linteus against methicillin-resistant Staphylococcus aureus, Fitoterapia, 75, 603, 10.1016/j.fitote.2004.06.005 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