Chemical constituents, biological functions and pharmacological effects for comprehensive utilization of Eucommia ulmoides Oliver

Voss, 1983, An integrated system of classification of flowering plants-cronquist A, Econ. Bot., 37 Li, 2012, Study advancement about chemical composition and pharmacological effects of Eucommia ulmoides Oliv, Sci. Technol. Food. Ind., 33, 153 Feng, 2015, Advances in chemical constituents and pharmacological action of Eucommia ulmoides Oliv, Chin. J. Clin. Pharm. Ther., 20, 713 He, 2014, Eucommia ulmoides Oliv.: ethnopharmacology, phytochemistry and pharmacology of an important traditional Chinese medicine, J. Ethnopharmacol., 151, 78, 10.1016/j.jep.2013.11.023 Zhang, 1996, Research and development of comprehensive utilization of Eucommia ulmoides Oliv, Chin. J. Inf. Tradit. Chin. Med., 3, 15 Zhang, 1996, Comparative study on the contents of Eucommia ulmoides Oliv. leaves and bark, J. Northwest Forestry College, 2, 42 Li, 1986, Preliminary study on chemical constituents of Eucommia ulmoides Oliv. bark and leaves, China J. Chin. Mater. Med., 11, 489 Yang, 2011, Comprehensive utilization of Eucommia ulmoides Oliv. in China, Guangzhou Chem. Ind., 39, 9 Song, 2006, Progress in study on properties and extraction of Eucommia ulmoides gutta-percha, Guizhou Chem. Ind., 31, 4 Zhang, 2011, Research status and progress on comprehensive development and uilization of samara of Eucommia ulmoides Oliver, The 10th National Conference on Medicinal Plants and Phytomedicines Peng, 2011 Wang, 1993, Research and application of Eucommia ulmoides Oliver, Chin. Trad. Herb. Drugs, 12, 655 Zheng, 2016 Bianco, 1975, ChemInform abstract: structure of eucommiol, a new cyclopentenoid – tetrol from Eucommia ulmoide, J. Cheminform, 30, 4117 Nakano, 1997, Anti-human immunodeficiency virus activity of oligosaccharides from rooibos tea (Aspalathus linearis) extracts in vitro, Leukemia, 11, 128 Yan, 2018, Analysis of chemical constituents in male flowers of Eucommia ulmoides by liquid chromatography coupled with electrospray ionization-triple quadrupole-time of flight-tandem mass spectrometry (LC-ESI-Triple TOF-MS/MS), Food Sci., 39, 215 Takamura, 2007, Studies on the chemical constituents of green leaves of Eucommia ulmoides Oliv, J. Nat. Med., 61, 220, 10.1007/s11418-006-0027-5 Peng, 2013, Simultaneous ligand fishing and identification of human serum albumin binders from Eucommia ulmoides bark using surface plasmon resonance-high performance liquid chromatography–tandem mass spectrometry, J. Chromatogr. B, 940, 86, 10.1016/j.jchromb.2013.09.032 Ding, 2015, Iridoid constituents from the male flower of Eucommia ulmoides and their promotion proliferation on ESF-1, J. Asian Nat. Prod. Res., 17, 867, 10.1080/10286020.2015.1039999 Bong Hyun, 2009, Elucidation of anti-inflammatory potencies of Eucommia ulmoides bark and Plantago asiatica seeds, J. Med. Food, 12, 764, 10.1089/jmf.2008.1239 Deyama, 2001, Constituents and pharmacological effects of Eucommia and Siberian ginseng, Acta Pharmacol. Sin., 22, 1057 Lee, 2018, Eucommia ulmoides leaf (EUL) extract enhances NO production in ox-LDL-treated human endothelial cells, Biomed. Pharmacother., 97, 1164, 10.1016/j.biopha.2017.11.035 Bianco, 1982, Structure elucidation of eucommioside (2”-0-beta-d-glucopyranosyl eucommiol) from Eucommia ulmoides, Phytochemistry, 21, 201, 10.1016/0031-9422(82)80043-5 Yahara, 1990, New iridoid trimers and tetramers from seeds of Eucommia ulmoides, Chem. Pharm. Bull., 38, 267, 10.1248/cpb.38.267 Guan, 2003, Advances in chemical constituents and pharmacology of Eucommia ulmoides Oliv, Chin. Med. Mater., 26, 124 Zhang, 1996, Screening and extraction of chlorogenic acid from Eucommia ulmoides leaves by capillary zone electrophoresis, Northwest Pharm. J., 2, 66 Wang, 2009, Comparison of the content of main effective constituents among different parts of Eucommia ulmoides, Nat. Prod. Res. Dev., 21, 108 Deyama, 1987, The constituents of Eucommia ulmoides Oliv. V. isolation of dihydroxydehydrodiconiferyl alcohol isomers and phenolic compounds, Chem. Pharm. Bull., 35, 1785, 10.1248/cpb.35.1785 Cheng, 2002, Studies on the phenylpropanoids from Eucommia ulmoides, China J. Chin. Mater. Med., 27, 38 Ding, 2014, Simultaneous quantification of eleven bioactive components of male flowers of Eucommia ulmoides oliver by HPLC and their quality evaluation by chemical fingerprint analysis with hierarchical clustering analysis, Pharmacogn. Mag., 10, 435, 10.4103/0973-1296.141813 Chuanling, 2008, Study on chemical compositions of Eucommia ulmoides Oliv. inner Bark and its extractives, Chem. Ind. Forest Prod., 28, 7 Zhang, 2014, Phenylpropanoids constituents of Eucommia ulmoides leaves, Chin. Med. Mater., 37, 421 Gewali, 1988, Constituents of the stems of Eucommia ulmoides Oliv, Shoyakugaku Zasshi, 42, 247 Si, 2013, Chemical constituents of the root barks of Eucommia ulmoides, Chem. Nat. Compd., 49, 974, 10.1007/s10600-013-0799-2 Yao, 2010 Cheng, 2000, Studies on flavonoids from leave of Eucommia ulmoides Oliv, China J. Chin. Mater. Med., 25, 284 Fu, 2007, Supercritical fluid extraction technology of flavonoids in Eucommia ulmoides Oliv. leaves and components analysis by LC–MS, Food Sci., 28, 128 Guo, 2015, Neuroprotective effects of Eucommia ulmoides Oliv. and its bioactive constituent work via ameliorating the ubiquitin–proteasome system, BMC Comple. Alter. Med., 15, 151, 10.1186/s12906-015-0675-7 Kim, 2004, Flavonol glycosides from the leaves of Eucommia ulmoides O. with glycation inhibitory activity, J. Ethnopharmacol., 93, 227, 10.1016/j.jep.2004.03.047 Kim, 2012, Eucommiae cortex inhibits TNF-α and IL-6 through the suppression of caspase-1 in lipopolysaccharide-stimulated mouse peritoneal macrophages, Am. J. Chin. Med., 40, 1, 10.1142/S0192415X12500115 Zhu, 2018, Eucommia ulmoides Oliver: a potential feedstock for bioactive products, J. Agric. Food. Chem., 66, 5433, 10.1021/acs.jafc.8b01312 Feng, 2007, Preparative isolation and purification of the lignan pinoresinol diglucoside and liriodendrin from the bark of Eucommia ulmoides Oliv. by high speed countercurrent chromatography, J. Liq. Chromatogr. Related Technol., 30, 135, 10.1080/10826070601036324 Du, 2017 Deyama, 1986, The constituents of Eucommia ulmoides Oliv. III: isolation and structure of a new lignan glycoside, Chem. Pharm. Bull., 34, 523, 10.1248/cpb.34.523 Deyama, 1985, The constituents of Eucommia ulmoides Oliv. II. Isolation and structures of three new lignan glycosides, Chem. Pharm. Bull., 33, 3651, 10.1248/cpb.33.3651 Deyama, 1983, The constituents of Eucommia ulmoides Oliv. I. isolation of (+)-Medioresinol di-O-β-d-glucopyranoside, Chem. Pharm. Bull., 31, 2993, 10.1248/cpb.31.2993 Shi, 2013, Combination of preparative HPLC and HSCCC methods to separate phosphodiesterase inhibitors from Eucommia ulmoides bark guided by ultrafiltration-based ligand screening, Anal. Bioanal. Chem., 405, 4213, 10.1007/s00216-013-6806-4 Bai, 2015, Soluble epoxide hydrolase inhibitory and anti-inflammatory components from the leaves of Eucommia ulmoides Oliver (Duzhong), J. Agric. Food. Chem., 63, 2198, 10.1021/acs.jafc.5b00055 Shimoyamo, 1993, Constituents of the leaf of Eucommia ulmoides Oliv, Shoyakugzku Zasshi, 47, 56 Deyama, 1987, The constituents of Eucommia ulmoides Oliv. VI. isolation of a new sesquilignan and neolignan glycosides, Chem. Pharm. Bull., 35, 1803, 10.1248/cpb.35.1803 Ding, 2014, Triterpenes constituents from male flowers of Eucommia ulmoides, China J. Chin. Mater. Med., 39, 4225 Li, 1986, The chemical constituents of Eucommia ulmoides Oliv, Chin. Bull. Botan., 28, 528 Xu, 1989, The constituents of Eucommia ulmoides Oliv, Chin. Bull. Botan., 31, 132 Hua, 2003, Study on the constituents of the bark of Eucommia ulmoides, Fenzi Zhiwu Yuzhong, 1, 801 Horri, 1978, Ulmoprenol, a new type C30-polyprenoid from Eucommia ulmoides Oliv, Tetrahedron Lett., 50, 5015, 10.1016/S0040-4039(01)85796-8 Chie, 1997, A new triterpenid from the leaves of Eucommia ulmoides Oliv, Chem. Pharm. Bull., 45, 1379, 10.1248/cpb.45.1379 Yan, 1991, New progress in the study of Eucommia ulmoides gutta-percha, Chem Bull, 1, 1 Yan, 2010, Development and application of Eucommia ulmoides rubber, Rubber Sci. Technol., 8, 9 Gonda, 1990, An acidic polysaccharide having activity on the reticuloendothelial system from the bark of Eucommia ulmoides, Chem. Pharm. Bull., 38, 1966, 10.1248/cpb.38.1966 Tomoda, 1990, A reticuloendothelial system-activating glycan from the barks of Eucommia ulmoides, Phytochemistry, 29, 3091, 10.1016/0031-9422(90)80163-B Zhang, 2010, Identification of the composition of fatty acids in Eucommia ulmoides seed oil by fraction chain length and mass spectrometry, Food Chem., 121, 815, 10.1016/j.foodchem.2009.12.089 Wang, 1994, Study on the amino acids of Eucommia ulmoides Oliv, J. Hebei University (Natural Science Edition), 2, 80 Lu, 2008, The development of compound product of Eucommiae, Lishizhen Med. Mater. Med. Res., 19, 1203 Zhang, 2002, Studies on the distribution differences of the secondary metabolites in Eucommia ulmoides, Sci. Silva. Sin., 38, 12 Tang, 2007, Effect of extractives of Eucommia ulmoides leaves on levels of blood pressure in awake rats, Chin. Hosp. Pharm. J., 27, 901 Kwan, 2004, Endothelium-dependent vasorelaxant effects of the aqueous extracts of the Eucommia ulmoides Oliv. leaf and bark: implications on their antihypertensive action, Vascular Pharmacol., 40, 229, 10.1016/j.vph.2003.09.001 Lang, 2005, Effect of Eucommia ulmoides on systolic blood pressure in the spontaneous hypertensive rat, Am. J. Chin. Med., 33, 215, 10.1142/S0192415X05002795 Luo, 2010, Antihypertensive effect of Eucommia ulmoides Oliv. extracts in spontaneously hypertensive rats, J. Ethnopharmacol., 129, 238, 10.1016/j.jep.2010.03.019 Gu, 2011, Effects of lignans extracted from Eucommia ulmoides and aldose reductase inhibitor epalrestat on hypertensive vascular remodeling, J. Ethnopharmacol., 133, 6, 10.1016/j.jep.2010.08.055 Hosoo, 2015, The restorative effects of Eucommia ulmoides Oliver leaf extract on vascular function in spontaneously hypertensive rats, Mol., 20, 21971, 10.3390/molecules201219826 Hosoo, 2017, Preventive effect of Eucommia leaf extract on aortic media hypertrophy in Wistar-Kyoto rats fed a high-fat diet, Hypertension Res., 40, 546, 10.1038/hr.2016.189 Lee, 2013, Eucommia ulmoides Oliver extract, aucubin, and geniposide enhance lysosomal activity to regulate ER stress and hepatic lipid accumulation, PLoS One, 8, e81349, 10.1371/journal.pone.0081349 Kobayashi, 2012, Facilitative effects of Eucommia ulmoides on fatty acid oxidation in hypertriglyceridaemic rats, J. Sci. Food Agric., 92, 358, 10.1002/jsfa.4586 Hirata, 2011, Anti-obesity compounds in green leaves of Eucommia ulmoides, Bioorg. Med. Chem. Lett., 21, 1786, 10.1016/j.bmcl.2011.01.060 Park, 2006, Hypoglycemic and hypolipidemic action of Du-zhong (Eucommia ulmoides Oliver) leaves water extract in C57BL/KsJ-db/db mice, J. Ethnopharmacol., 107, 412, 10.1016/j.jep.2006.03.034 Choi, 2008, Du-zhong (Eucommia ulmoides Oliver) leaf extract mediates hypolipidemic action in hamsters fed a high-fat diet, Am. J. Chin. Med., 36, 81, 10.1142/S0192415X08005606 Horii, 2010, Effects of Eucommia leaf extracts on autonomic nerves, body temperature, lipolysis, food intake, and body weight, Neurosci. Lett., 479, 181, 10.1016/j.neulet.2010.05.030 Lee, 2014, Eucommia ulmoides cortex, geniposide and aucubin regulate lipotoxicity through the inhibition of lysosomal BAX, PLoS One, 9, e88017, 10.1371/journal.pone.0088017 Hao, 2016, Chlorogenic acid-enriched extract from Eucommia ulmoides leaves inhibits hepatic lipid accumulation through regulation of cholesterol metabolism in HepG2 cells, Pharm. Biol., 54, 251, 10.3109/13880209.2015.1029054 Jin, 2013, Mechanism of the inhibitory effects of Eucommia ulmoides Oliv. cortex extracts (EUCE) in the CCl4-Induced acute liver lipid accumulation in rats, Int. J. Endocrinol., 1, 10.1155/2013/751854 Lou, 2009, Regulation effects of Eucommia ulmoides male flower tea on lipid parameters of mice fed with high fat emul, J. Henan Univ. (Med. Sci.), 28, 273 Lee, 2005, Hypoglycemic effect of Du-zhong (Eucommia ulmoides Oliv.) leaves in streptozotocin-induced diabetic rats, Diabetes Res. Clin. Pr., 67, 22, 10.1016/j.diabres.2004.05.013 Jin, 2010, Ameliorative effect of Eucommia ulmoides Oliv. leaves extract (ELE) on insulin resistance and abnormal perivascular innervation in fructose-drinking rats, J. Ethnopharmacol., 128, 672, 10.1016/j.jep.2010.02.019 Cheng, 2016, Eucommia bark (Du-Zhong) improves diabetic nephropathy without altering blood glucose in type 1-like diabetic rats, Drug Des. Dev. Ther., 10, 971, 10.2147/DDDT.S98558 Do, 2018, Eucommia ulmoides ameliorates glucotoxicity by suppressing advanced glycation end-products in diabetic mice kidney, Nutrients, 10, e265, 10.3390/nu10030265 Park, 2006, Eucommia ulmoides Oliver leaf extract increases endogenous antioxidant activity in type 2 diabetic mice, J. Med. Food, 9, 474, 10.1089/jmf.2006.9.474 Zhang, 2015, The ethanol extract of Eucommia ulmoides Oliv. leaves inhibits disaccharidase and glucose transport in Caco-2 cells, J. Ethnopharmacol., 163, 99, 10.1016/j.jep.2015.01.015 Xu, 2010, Antioxidant properties of Du-zhong (Eucommia ulmoides Oliv.) extracts and their effects on color stability and lipid oxidation of raw pork patties, J. Agric. Food. Chem., 58, 7289, 10.1021/jf100304t Yen, 2000, Reactive oxygen species scavenging activity of Du-zhong (Eucommia ulmoides Oliv.) and its active compounds, J. Agric. Food. Chem., 48, 3431, 10.1021/jf000150t Ho, 2005, Protective effects of aucubin isolated from Eucommia ulmoides against UVB-induced oxidative stress in human skin fibroblasts, Biol. Pharm. Bull., 28, 1244, 10.1248/bpb.28.1244 Hsieh, 2000, Antioxidant actions of Du-zhong (Eucommia ulmoides Oliv.) toward oxidative damage in biomolecules, Life Sci., 66, 1387, 10.1016/S0024-3205(00)00450-1 Lin, 2011, Eucommia ulmoides Oliv. antagonizes H2O2-induced rat osteoblastic MC3T3-E1 apoptosis by inhibiting expressions of caspases 3, 6, 7, and 9, J. Zhejiang Univ. Sci. B, 12, 47, 10.1631/jzus.B1000057 Du, 2011, Effects of Eucommia ulmoides male flower tea on SOD, GSH-Px activity and MDA level in D-galactose aging model mice, Chin. Trad. Patent Med., 33, 331 Qiu, 2013, Evaluation of the antioxidant ativity of the extracts from Eucommia male flower in vitro, Sci. Silva. Sin., 49, 63 Xiang, 2011, Antioxidant activity in vitro of seed oil from Eucommia ulmoides Oliver key fruits, Food Sci., 32, 133 Luo, 2014, Anti-inflammatory activity of iridoid and catechol derivatives from Eucommia ulmoides Oliver, ACS Chem. Neurosci., 5, 855, 10.1021/cn5001205 Jiang, 2011, Beneficial effect of Eucommia polysaccharides on systemic lupus erythematosus-like syndrome induced by campylobacter jejuni in BALB/c mice, Inflam., 34, 402, 10.1007/s10753-010-9247-7 Lee, 2018, Anti-inflammatory effect of stem bark of Paulownia tomentosa Steud. in lipopolysaccharide (LPS)-stimulated RAW264.7 macrophages and LPS-induced murine model of acute lung injury, J. Ethnopharmacol., 210, 23, 10.1016/j.jep.2017.08.028 Koh, 2017, Anti-inflammatory effect of cortex Eucommiae via modulation of the toll-like receptor 4 pathway in lipopolysaccharide-stimulated RAW 264.7 macrophages, J. Ethnopharmacol., 209, 255, 10.1016/j.jep.2017.08.001 Wang, 2016, Extract from Eucommia ulmoides Oliv. ameliorates arthritis via regulation of inflammation, synoviocyte proliferation and osteoclastogenesis in vitro and in vivo, J. Ethnopharmacol., 194, 609, 10.1016/j.jep.2016.10.038 Hiramoto, 2018, Preventive effects of Eucommia ulmoides leaf extract and its components on UVB-induced immunosuppression in mice, J. Funct. Foods, 48, 351, 10.1016/j.jff.2018.07.030 Yang, 2017, Gastroprotective effect of aucubin against ethanol-induced gastric mucosal injury in mice, Life Sci., 189, 44, 10.1016/j.lfs.2017.09.016 Wu, 2018, Effect of Eucommia ulmoides Oliv., Gynostemma pentaphyllum (Thunb.) Makino, and Curcuma longa L. on Th1-and Th2-cytokine responses and human leukocyte antigen-DR expression in peripheral blood mononuclear cells of septic patients, J. Ethnopharmacol., 217, 195, 10.1016/j.jep.2018.02.024 Kwon, 2016, The anti-inflammatory activity of Eucommia ulmoides Oliv. Bark. involves NF-κB suppression and Nrf2-dependent HO-1 induction in BV-2 microglial cells, Biomol. Ther., 24, 268, 10.4062/biomolther.2015.150 Kwon, 2011, Neuroprotective effects of Eucommia ulmoides Oliv. Bark on amyloid beta (25-35)-induced learning and memory impairments in mice, Neurosci. Lett., 487, 123, 10.1016/j.neulet.2010.10.042 Kwon, 2012, Eucommia ulmoides Oliv. Bark. protects against hydrogen peroxide-induced neuronal cell death in SH-SY5Y cells, J. Ethnopharmacol., 142, 337, 10.1016/j.jep.2012.04.010 Kwon, 2014, Eucommia ulmoides Oliv. bark attenuates 6-hydroxydopamine-induced neuronal cell death through inhibition of oxidative stress in SH-SY5Y cells, J. Ethnopharmacol., 152, 173, 10.1016/j.jep.2013.12.048 Hu, 2014, Neuroprotective effects of macranthoin G from Eucommia ulmoides against hydrogen peroxide-induced apoptosis in PC12 cells via inhibiting NF-kappa B activation, Chem. Biol. Interactions, 224, 108, 10.1016/j.cbi.2014.10.011 Li, 2016, Neuroprotective effect of lignans extracted from Eucommia ulmoides Oliv. on glaucoma-related neurodegeneration, Neurol. Sci., 37, 755, 10.1007/s10072-016-2491-3 Wang, 2017, The protective effect of aucubin from Eucommia ulmoides against status epilepticus by inducing autophagy and inhibiting necroptosis, Am. J. Chin. Med., 45, 557, 10.1142/S0192415X17500331 Qi, 2019, Du-Zhong (Eucommia ulmoides Oliv.) cortex extract alleviates lead acetate-induced bone loss in rats, Biol. Trace Elem. Res., 187, 172, 10.1007/s12011-018-1362-6 Zhang, 2009, Du-Zhong (Eucommia ulmoides Oliv.) cortex extract prevent OVX-induced osteoporosis in rats, Bone, 45, 553, 10.1016/j.bone.2008.08.127 Pan, 2014, Du-Zhong (Eucommia ulmoides) prevents disuse-induced osteoporosis in hind limb suspension rats, Am. J. Chin. Med., 42, e1450010, 10.1142/S0192415X14500104 Kim, 2015, Effects of Eucommia ulmoides extract on longitudinal bone growth rate in adolescent female rats, Phytother. Res., 29, 148, 10.1002/ptr.5195 Lee, 2016, Regulation of osteoclastic and osteoblastic differentiation marker expressions in osteoblast-like saos-2 cells by Eucommia ulmoides, Orient. Pharm. Exp. Med., 16, 53, 10.1007/s13596-015-0214-6 Hung, 2006, Du-Zhong (Eucommia ulmoides Oliv.) leaves inhibits CCl4-induced hepatic damage in rats, Food Chem. Toxicol., 44, 1424, 10.1016/j.fct.2006.03.009 Gao, 2011, Protective effects of the alcohol extract and the water extract from Eucommia ulmoides oliver on immunological liver injury in mice, J. North China Coal Med. Univ., 13, 141 Zheng, 2012, Protective effects of different extracts of Eucommia ulmoides Oliv. against thioacetamide-induced hepatotoxicity in mice, Indian J. Exp. Biol., 50, 875 Jin, 2008, Study on anti-fatigue effects of Eucommia ulmoides male flower tea on mice, Food. Sci., 29, 432 Dong, 2010, The anti-fatigue effect of Eucommia ulmoides leaves in mice, 2010 4th International Conference on Bioinformatics and Biomedical Engineering Lin, 2014, In vivo anti-hypoxia and anti-fatigue activities of flavonoids from bark of Eucommia ulmoides, Appl. Mech. Mater., 675–677, 1608, 10.4028/www.scientific.net/AMM.675-677.1608 Li, 2000, The promoting effect of eucommiol from eucommiae cortex on collagen synthesis, Biol. Pharm. Bull., 23, 54, 10.1248/bpb.23.54 Sugawa, 2016, Eucommia ulmoides extracts prevent the formation of advanced glycation end products, Food Func., 7, 2566, 10.1039/C5FO01563D Li, 2017, Evaluation of the sedative and hypnotic effects of astragalin isolated from Eucommia ulmoides leaves in mice, Nat. Prod. Res., 31, 2072, 10.1080/14786419.2016.1272108 Wu, 2016, Antidepressant potential of chlorogenic acid-enriched extract from Eucommia ulmoides Oliver bark with neuron protection and promotion of serotonin release through enhancing synapsin I expression, Mol., 21, 260, 10.3390/molecules21030260 Kwon, 2013, Inhibitory effects of Eucommia ulmoides Oliv. bark on scopolamine-induced learning and memory deficits in mice, Biomol. Ther., 21, 462, 10.4062/biomolther.2013.074