Chemical constituents and cytotoxicity of Aspidistra letreae

Hue University Journal of Science: Natural Science - Tập 129 Số 1B - Trang 31-39 - 2020
Duc Viet Ho1, Hanh Nhu Thi Hoang2, Khue Minh Vo3, Anh Tuan Le4, Hoai Thi Nguyen1
1University of Medicine and Pharmacy, Hue University, 6 Ngo Quyen St., Hue, Vietnam
2University of Agriculture and Forestry, Hue University, 102 Phung Hung St., Hue, Vietnam
3University of Education, Hue University, 34 Le Loi St., Hue, Vietnam
4Quang Tri Center of Science and Technology, Mientrung Inst. for Scientific Research, VAST, Dien Bien Phu St., Quang Tri, Vietnam

Tóm tắt

A phytochemical investigation of whole Aspidistra letreae plants led to the isolation of 2H-chromen-2-one (1), α-tocopherol (2), (E)-phytol (3), asparenydiol (4) and (25S)-spirost-1β,3α,5β-triol (5). Their structures were determined on the basis of NMR spectral evidences and in comparison with the reported data. Of these, asparenydiol (4) was isolated from the genus Aspidistra for the first time. This is also the first report on the separation and structural determination of (25S)-spirost-1β,3α,5β-triol (5) as a pure compound. The methanol extract from the whole plants of Aspidistra letreae exhibits moderate cytotoxicity against the LU-1, HeLa, MDA-MB-231, Hep-G2, and MKN-7 human cancer cell lines with IC50 values ranging from 52.58 ± 3.65 to 64.78 ± 4.89 μg/mL.

Từ khóa

#NMR #bioactivity #anticancer #cytotoxicity #extraction #isolation #structure elucidation

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Hue University Journal of Science: Natural Science

Tập 129 Số 1B

31-39

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