Chemical Synthesis and Biological Screening of 2‐Aminoimidazole‐Based Bacterial and Fungal Antibiofilm Agents

ChemBioChem - Tập 11 Số 3 - Trang 396-410 - 2010
Steven A. Rogers1, Joseph D. Bero1, Christian Melander1
1Chemistry, North Carolina State University, 2620 Yarborough Drive, Raleigh, NC, 27695‐8204 (USA), Fax: (+1) 919‐513‐2960

Tóm tắt

AbstractA collection of 2‐aminoimidazole/triazole amides has been synthesized and screened for antibiofilm activity. This class of small molecules was found to modulate the biofilm activity of Pseudomonas aeruginosa, a multidrug‐resistant strain of Acinetobacter baumannii (MDRAB), a methicillin‐resistant Staphylococcus aureus strain (MRSA), Escherichia coli, Rhodospirillum salexigens, Staphylococcus epidermidis, Vibrio vulnificus, and vancomycin‐resistant Enterococcus faecium as well as the yeast Candida albicans and Cryptococcus neoformans. Furthermore, lead compounds were found to not lyse red blood cells at active concentrations.

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Thông tin xuất bản

ChemBioChem

Tập 11 Số 3

396-410

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