Characterizing intrinsic functional connectivity in relation to impaired self-regulation in intellectually able male youth with autism spectrum disorder

Autism - Tập 24 Số 5 - Trang 1201-1216 - 2020
Hsiang‐Yuan Lin1,2, Hsing‐Chang Ni3,1, Wen‐Yih Isaac Tseng1, Susan Shur‐Fen Gau1,2
2National Taiwan University Hospital
3Chang Gung Memorial Hospital at Linkou

Tóm tắt

While a considerable number of youth with autism spectrum disorder exhibit impaired self-regulation (dysregulation), little is known about the neural correlates of dysregulation in autism spectrum disorder. In a sample of intellectually able boys with autism spectrum disorder (further categorized as those with and without dysregulation) and typically developing boys (aged 7–17 years), we conducted a multivariate connectome-wide association study to examine the intrinsic functional connectivity with resting-state functional magnetic resonance imaging. Dysregulation was defined by the sum of Attention, Aggression, and Anxiety/Depression subscales on the Child Behavior Checklist. We identified that both categorical and dimensional neural correlates of dysregulation in youth with autism spectrum disorder involved atypical connectivity among the components of multiple brain networks, especially between those subserving sensorimotor processing and salience encoding, beyond higher-level cognitive control circuitries. Interaction within the attention network might serve as autism spectrum disorder–specific neural correlates underpinning dysregulation. Our results highlight that the inter-individual variability in dysregulation might contribute to the inconsistency in the neuroimaging literature of autism spectrum disorder. Collectively, the present findings provide evidence to suggest that dysregulation might be considered as both categorical and dimensional moderators to parse heterogeneity of autism spectrum disorder.Lay AbstractImpaired self-regulation (i.e., dysregulation in affective, behavioral, and cognitive control), is commonly present in young people with autism spectrum disorder (ASD). However, little is known about what is happening in people’s brains when self-regulation is impaired in young people with ASD. We used a technique called functional MRI (which measures brain activity by detecting changes associated with blood flow) at a resting state (when participants are not asked to do anything) to research this in intellectually able young people with ASD. We found that brains with more connections, especially between regions involved in sensorimotor processing and regions involved in the processes that enable peoples to focus their attention on the most pertinent features from the sensory environment (salience processing), were related to more impaired self-regulation in young people with and without ASD. We also found that impaired self-regulation was related to increased communication within the brain system involved in voluntary orienting attention to a sensory cue (the dorsal attention network) in young people with ASD. These results highlight how different people have different degrees of dysregulation, which has been largely overlooked in the earlier brain imaging reports on ASD. This might contribute to understanding some of the inconsistencies in the existing published literature on this topic.

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Tài liệu tham khảo

10.1093/scan/nsw027

10.1016/j.jaac.2010.08.006

10.1111/j.1469-7610.2009.02089.x

10.1016/j.neuroimage.2007.04.042

10.1089/brain.2016.0472

10.2147/NDT.S29670

10.1016/j.biopsych.2006.02.028

10.1016/j.tics.2010.04.004

10.1152/jn.00339.2011

10.1016/j.bpsc.2016.03.004

10.1016/j.neuroimage.2017.03.020

10.1016/j.tics.2013.08.006

10.1038/nrn755

10.1089/brain.2016.0475

Cuthbert B. N., 2015, Dialogues in Clinical Neuroscience, 17, 89, 10.31887/DCNS.2015.17.1/bcuthbert

10.1017/S0954579417000955

Dichter G. S., 2012, Dialogues in Clinical Neuroscience, 14, 319, 10.31887/DCNS.2012.14.3/gdichter

10.1038/sdata.2017.10

10.1038/mp.2013.78

10.1073/pnas.1602413113

10.1038/nrn4044

10.1111/desc.12359

10.1176/appi.ajp.162.7.1344

10.1111/j.1440-1819.2009.02034.x

10.1111/j.1469-7610.2009.02183.x

10.1146/annurev.psych.121208.131616

10.3389/fpsyt.2016.00205

10.1523/JNEUROSCI.0067-17.2017

10.1006/nimg.2002.1132

10.1523/JNEUROSCI.4837-12.2013

10.1007/s10803-006-0147-5

10.1016/j.tics.2017.02.002

10.1007/s10548-015-0454-2

10.1007/BF02172145

10.1007/s10803-016-2907-1

10.1016/j.jaac.2013.05.006

10.1093/cercor/bhv005

10.1007/s11682-017-9678-y

10.1016/j.biopsych.2015.08.029

10.1016/j.pnpbp.2017.11.008

10.1146/annurev-clinpsy-032511-143109

10.1016/j.bpsc.2018.11.010

10.1016/j.neuroimage.2017.12.073

10.1016/j.neuroimage.2013.04.013

10.1016/j.dcn.2014.08.007

10.1016/j.neuroimage.2015.02.064

10.1007/s10803-015-2359-z

10.1093/cercor/bhr171

10.1016/j.neuroimage.2014.02.024

10.1111/j.1469-7610.2012.02600.x

10.3389/fnhum.2019.00104

10.3810/pgm.2011.09.2459

10.1016/j.neuron.2014.03.020

10.1093/cercor/bhu161

10.1016/j.bpsc.2016.02.003

10.1016/j.dcn.2013.12.002

10.3389/fnhum.2013.00746

10.1002/aur.1426

10.1089/brain.2012.0073

10.1371/journal.pbio.1002036

10.1016/j.neuroimage.2013.04.081

10.3389/fnsys.2010.00013

10.1152/jn.00338.2011

10.1016/j.nicl.2015.07.018

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Autism

Tập 24 Số 5

1201-1216

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