Characterization of proteoglycans and glycosaminoglycans in bovine renal AA-type amyloidosis

Springer Science and Business Media LLC - Tập 60 - Trang 321-328 - 1991
Th. A. Niewold1, J. M. Flores Landeira2, L. P. W. J. van den Heuvel3, A. Ultee1, P. C. J. Tooten1, J. H. Veerkamp3
1Department of Pathology, Veterinary Faculty, University of Utrecht, The Netherlands
2Department of Histology and Pathological Anatomy, Veterinary Faculty, Universidad Complutense, Madrid, Spain
3Department of Biochemistry, University of Nijmegen, The Netherlands

Tóm tắt

Highly sulfated glycosaminoglycans (GAG) or proteoglycans (PG), especially heparan sulfate (HS) and heparan sulfate proteoglycan (HSPG), are considered to be intimately associated with amyloid deposits in different types of amyloidosis. Based on this relationship an important role for HS has been suggested in amyloidogenesis. The present immunohistological and ultrastructural study shows that in bovine renal AAamyloidosis, sulfated GAG/PG was not restricted to amyloid deposits proper and that areas without GAP/ PG were also present within the amyloid. Both glomerular and papillary amyloid contained HS (PG), and the latter also contained chondroitin sulfate (CS) and dermatan sulfate (DS), suggesting a correlation between the location of the amyloid and the type of GAG/PG deposited. Amyloid P component (AP) had a distribution similar to that of HSPG, confirming their affinity-based relationship. The GAG types found ultrastructurally in amyloid fibril preparations of glomerular and papillary amyloid isolated from the same kidney, reflected the immunohistological findings. HS was shown to be the predominant GAG in all papillary amyloid fibril extracts. Taking into account the chemico-physical properties of HS, it cannot be excluded that this predominance is introduced by the purification procedure. These results suggest that the association of GAG/PG and amyloid is not necessarily mutually obligatory and that the proposed importance of GAG in amyloidogenesis is disputable.

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Springer Science and Business Media LLC

Tập 60

321-328

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