Characterization of conotruncal malformations following ablation of “cardiac” neural crest

Wiley - Tập 213 Số 1 - Trang 87-93 - 1985
Margaret L. Kirby1, Kirby L. Turnage1, Beth M. Hays1
1Department of Anatomy, Medical College of Georgia, Augusta, GA 30912

Tóm tắt

AbstractNeural crest cells from the cranial region of the neural fold populate the outflow tract of the developing chick heart. Removal of this region of premigratory neural crest has been shown previously to result in a high percentage of conotruncal malformations. The present study was undertaken to define more precisely the regions of premigratory neural crest which are needed for normal conotruncal development. Various regions and lengths of premigratory cranial neural crest were ablated using microcautery. Three defects in conotruncal development were significantly correlated with the neural crest ablation. These were high venticular septal defect, single outflow vessel originating from the right ventricle, and single outflow vessel overriding the ventricular septum.

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Thông tin xuất bản

Wiley

Tập 213 Số 1

87-93

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