Characterization of Hemodynamic Events Following Intravascular Infusion of Recombinant Adenovirus Reveals Possible Solutions for Mitigating Cardiovascular Responses

Ben-Gary, 2002, Systemic interleukin-6 responses following administration of adenovirus gene transfer vectors to humans by different routes, Mol. Ther., 6, 287, 10.1006/mthe.2002.0658 Cichon, 1999, Intravenous administration of recombinant adenoviruses causes thrombocytopenia, anemia and erythroblastosis in rabbits, J. Gene Med., 1, 360, 10.1002/(SICI)1521-2254(199909/10)1:5<360::AID-JGM54>3.0.CO;2-Q Lieber, 1997, The role of Kupffer cell activation and viral gene expression in early liver toxicity after infusion of recombinant adenovirus vectors, J. Virol., 71, 8798, 10.1128/JVI.71.11.8798-8807.1997 Lozier, 2002, Toxicity of a first-generation adenoviral vector in rhesus macaques, Hum. Gene Ther., 13, 113, 10.1089/10430340152712665 Morral, 2002, Lethal toxicity, severe endothelial injury, and a threshold effect with high doses of an adenoviral vector in baboons, Hum. Gene Ther., 13, 143, 10.1089/10430340152712692 Muruve, 1999, Adenoviral gene therapy leads to rapid induction of multiple chemokines and acute neutrophil-dependent hepatic injury in vivo, Hum. Gene Ther., 10, 965, 10.1089/10430349950018364 Raper, 2002, A pilot study of in vivo liver-directed gene transfer with an adenoviral vector in partial ornithine transcarbamylase deficiency, Hum. Gene Ther., 13, 163, 10.1089/10430340152712719 Reid, 2002, Intravascular adenoviral agents in cancer patients: lessons from clinical trials, Cancer Gene Ther., 9, 979, 10.1038/sj.cgt.7700539 Reid, 2002, Hepatic arterial infusion of a replication-selective oncolytic adenovirus (dl1520): phase II viral, immunologic, and clinical endpoints, Cancer Res., 62, 6070 Schnell, 2001, Activation of innate immunity in nonhuman primates following intraportal administration of adenoviral vectors, Mol. Ther., 3, 708, 10.1006/mthe.2001.0330 Zhang, 2001, Acute cytokine response to systemic adenoviral vectors in mice is mediated by dendritic cells and macrophages, Mol. Ther., 3, 697, 10.1006/mthe.2001.0329 Raper, 2003, Fatal systemic inflammatory response syndrome in an ornithine transcarbamylase deficient patient following adenoviral gene transfer, Mol. Genet. Metab., 80, 148, 10.1016/j.ymgme.2003.08.016 O'Neal, 1998, Toxicological comparison of E2a-deleted and first-generation adenoviral vectors expressing alpha1-antitrypsin after systemic delivery, Hum. Gene Ther., 9, 1587, 10.1089/hum.1998.9.11-1587 Varnavski, 2002, Preexisting immunity to adenovirus in rhesus monkeys fails to prevent vector-induced toxicity, J. Virol., 76, 5711, 10.1128/JVI.76.11.5711-5719.2002 Liu, 2003, The role of capsid–endothelial interactions in the innate immune response to adenovirus vectors, Hum. Gene Ther., 14, 627, 10.1089/104303403321618146 Lozier, 1999, Adenovirus-mediated expression of human coagulation factor IX in the rhesus macaque is associated with dose-limiting toxicity, Blood, 94, 3968, 10.1182/blood.V94.12.3968 Higginbotham, 2002, The release of inflammatory cytokines from human peripheral blood mononuclear cells in vitro following exposure to adenovirus variants and capsid, Hum. Gene Ther., 13, 129, 10.1089/10430340152712683 Wolff, 1997, Enhancement of in vivo adenovirus-mediated gene transfer and expression by prior depletion of tissue macrophages in the target organ, J. Virol., 71, 624, 10.1128/JVI.71.1.624-629.1997 Zaiss, 2002, Differential activation of innate immune responses by adenovirus and adeno-associated virus vectors, J. Virol., 76, 4580, 10.1128/JVI.76.9.4580-4590.2002 Rea, 1999, Adenoviruses activate human dendritic cells without polarization toward a T-helper type 1-inducing subset, J. Virol., 73, 10245, 10.1128/JVI.73.12.10245-10253.1999 Oberholzer, 2002, Increased survival in sepsis by in vivo adenovirus-induced expression of IL-10 in dendritic cells, J. Immunol., 168, 3412, 10.4049/jimmunol.168.7.3412 Schiedner, 2003, A hemodynamic response to intravenous adenovirus vector particles is caused by systemic Kupffer cell-mediated activation of endothelial cells, Hum. Gene Ther., 14, 1631, 10.1089/104303403322542275 Rahman, 2001, Specific depletion of human anti-adenovirus antibodies facilitates transduction in an in vivo model for systemic gene therapy, Mol. Ther., 3, 768, 10.1006/mthe.2001.0316 Whalen, 2000, Functional evidence for the rapid desensitization of 5-HT(3) receptors on vagal afferents mediating the Bezold–Jarisch reflex, Brain Res., 873, 302, 10.1016/S0006-8993(00)02526-9 Whalen, 2000, Beta-adrenoceptor dysfunction after inhibition of NO synthesis: functional evidence for the rapid desensitization of 5-HT(3) receptors on vagal afferents mediating the Bezold–Jarisch reflex, Hypertension, 36, 376, 10.1161/01.HYP.36.3.376 Travis, 1997, Heterologous desensitization of beta-adrenoceptor signal transduction in vivo, Eur. J. Pharmacol., 328, R1, 10.1016/S0014-2999(97)83035-X Lopez, 1997, Hemodynamic effects of intracoronary VEGF delivery: evidence of tachyphylaxis and NO dependence of response, Am. J. Physiol., 273, H1317 Donahue, 2000, Focal modification of electrical conduction in the heart by viral gene transfer, Nat. Med., 6, 1395, 10.1038/82214 Morrissey, 2002, Porcine toxicology studies of SCH 58500, an adenoviral vector for the p53 gene, Toxicol. Sci., 65, 256, 10.1093/toxsci/65.2.256 Huyghe, 1995, Purification of a type 5 recombinant adenovirus encoding human p53 by column chromatography, Hum. Gene Ther., 6, 1403, 10.1089/hum.1995.6.11-1403 Shabram, 1997, Analytical anion-exchange HPLC of recombinant type-5 adenoviral particles, Hum. Gene Ther., 8, 453, 10.1089/hum.1997.8.4-453 Shabram, 2000, Multiplicity of infection/multiplicity of confusion, Mol. Ther., 2, 420, 10.1006/mthe.2000.0212 Vellekamp, 2001, Empty capsids in column-purified recombinant adenovirus preparations, Hum. Gene Ther., 12, 1923, 10.1089/104303401753153974 Van Rooijen, 1994, Liposome mediated depletion of macrophages: mechanism of action, preparation of liposomes and applications, J. Immunol. Methods, 174, 83, 10.1016/0022-1759(94)90012-4