Characteristics of executive function impairment in Parkinson’s disease patients without dementia

Journal of the International Neuropsychological Society - Tập 16 Số 2 - Trang 268-277 - 2010
Audrey McKinlay1, Randolph C. Grace1, John C. Dalrymple‐Alford1, Derek Roger1
1Department of Psychology, University of Canterbury, Christchurch, New Zealand

Tóm tắt

AbstractExecutive function impairments in Parkinson’s disease (PD) are well documented. However, uncertainties remain regarding the impact of these deficits on other areas of cognitive functioning. The goal of this study was to provide a comprehensive assessment of cognitive characteristics in patients with PD without dementia and to assess how any such deficits affected other areas of cognitive functioning. Forty PD patients without dementia were compared to healthy controls using measures of attention and speed of processing and a comprehensive set of executive function tests including working memory, planning, and problem solving. Measures of memory/learning and visuospatial skills were also included to examine the relationship between aspects of executive function and other areas of cognition. Patients with PD showed deficits on measures of executive function, problem solving, and visuospatial skills. However, they were unimpaired on measures of planning, attention, and memory/learning. Deficits in problem solving were only evident for tasks with a high visuospatial content and were no longer significant when visuospatial skills were controlled for. While deficits in executive function and visuospatial skills were apparent for PD patients compared to controls, many aspects of cognition remained intact. These can provide a focus for cognitive intervention strategies that can be effective in delaying decline for PD patients. (JINS, 2010, 16, 268–277.)

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Tài liệu tham khảo

10.1037/0894-4105.11.1.44

10.1097/00146965-200312000-00001

10.2466/pms.2000.90.2.562

10.1097/00019442-200510000-00003

Wechsler, 1999, Abbreviated Scale of Intelligence

Wechsler, 1997, WAIS-III, WMS-III technical manual

10.1007/978-3-7091-0579-5_5

10.1155/1995/167286

Spreen, 1998, A compendium of neuropsychological tests

10.1136/jnnp.69.3.308

10.1016/j.jns.2006.05.028

10.1212/01.wnl.0000180516.69442.95

10.1016/j.neuropsychologia.2007.08.018

McKinlay, 2008, Neuropsychiatric problems in Parkinson’s disease: Comparisons between self and significant other report, Aging and Mental Health, 5, 649

Jurica, 2001, DRS-2 Dementia Rating Scale-2. Professional manual

10.1177/0891988705277540

Fahn, 1987, Unified Parkinson’s Disease Rating Scale, 2

10.1016/j.neuropsychologia.2006.04.013

10.1017/S1355617703910022

10.1016/j.jns.2006.05.037

10.1212/WNL.17.5.427

10.1016/S0278-2626(03)00180-5

10.1046/j.1468-1331.2000.00066.x

10.1037/0894-4105.13.1.135

10.1212/WNL.45.9.1691

10.1016/S0022-5371(80)90312-6

10.1016/j.neubiorev.2005.03.024

10.1016/0166-2236(90)90058-I

10.1212/WNL.0b013e3181b0bd3d

10.1002/gps.389

10.1007/s00415-008-0720-2

10.1093/brain/awf052

10.1136/jnnp.64.5.588

10.1016/j.archger.2004.04.049

Wilson, 1996, Behavioural Assessment of the Dysexecutive Syndrome

10.1007/PL00007725

10.1177/1073858404266776

Pillon, 2001, Handbook of neuropsychology, 6, 311

10.1007/s00415-005-0971-0

10.1080/01688639508405165

Lezak, 1995, Neuropsychological assessment

Beck, 1996, Beck Depression Inventory

10.1093/brain/114.5.2095

10.1037/0894-4105.19.4.532

10.1136/jnnp.2003.033530

10.1212/01.wnl.0000304050.05332.9c

10.1159/000113474

10.1006/brcg.1995.1258

10.1080/09084280903098661

10.1001/archneur.1978.00500300038006

Levin, 1995, Early cognitive changes and nondementing behavioral abnormalities in Parkinson’s disease, Advances in Neurology, 65, 85

10.1002/1531-8257(199901)14:1<10::AID-MDS1005>3.0.CO;2-4

10.1159/000068483

10.1007/PL00007758

10.1016/0022-3956(75)90026-6

10.1016/S0304-3940(98)00928-8

10.1212/01.WNL.0000091864.39702.1C

10.1037/0894-4105.7.1.89

Delis, 2001, Delis Kaplan Executive Function System

10.1002/mds.21677

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Journal of the International Neuropsychological Society

Tập 16 Số 2

268-277

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