Changes in peritoneal permeability due to chemical fibrosis

Journal of Artificial Organs - Tập 1 - Trang 76-79 - 1998
Kayo Hayashi1, Yuji Ohta2, Kazuo Kumano3, Takashi Horiuchi1
1Division of Applied Life Science, Graduate School of University of East Asia, Shimonoseki, Japan
2Department of Mechanical Engineering, Toyo University, Kawagoe, Japan
3Kidney Center, Kitasato University Hospital, Kitasato, Sagamihara, Japan

Tóm tắt

A relation between the mass transfer area coefficient (MTAC) and development of chemically induced fibrosis was evaluated. 20ml/kg of 0.08–0.2wt% chlorhexidine gluconate (CHG) was injected into the abdominal space of male Wistar rats (at 8 weeks). After 1–2h dwell, CHG was discarded and then the abdominal space was flushed with 20ml/kg of 0.9% saline solution three times. A peritoneal equilibration test (PET) was carried out every week for 1 month using Lactate Ringer solution containing 100 mg/dl of urea-N, 10 mg/dl of creatinine, and 1.5% of albumin. Eight out of 11 rats survived, 5 out of 8 rats developed adhesions, and 1 developed sclerosing encapsulating peritonitis-like degeneration. Although there was no statistically significant change in MTAC, MTAC increased from 1.18±0.66 ml/min to 1.92±0.6 ml/min in the first 3 weeks (P=0.09), and slightly decreased at the fourth week. It can be concluded that increase of MTAC may be due to increase of peritoneal permeability and/or increase of effective surface area such as angiogenesis.

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Journal of Artificial Organs

Tập 1

76-79

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