Challenge to Metabolomics of Oral Biofilm

Marsh, 1994, Microbial ecology of dental plaque and its significance in health and disease, Adv. Dent. Res, 8, 263, 10.1177/08959374940080022001

Tanzer, 2001, The microbiology of primary dental caries in humans, J. Dent. Educ, 65, 1028, 10.1002/j.0022-0337.2001.65.10.tb03446.x

Becker, 2002, Molecular analysis of bacterial species associated with childhood caries, J. Clin. Microbiol, 40, 1001, 10.1128/JCM.40.3.1001-1009.2002

Chhour, 2005, Molecular analysis of microbial diversity in advanced caries, J. Clin. Microbiol, 43, 843, 10.1128/JCM.43.2.843-849.2005

Ledder, 2007, Molecular analysis of the subgingival microbiota in health and disease, Appl. Environ. Microbiol, 73, 516, 10.1128/AEM.01419-06

Kurita-Ochiai, 2008, Butyric acid induces apoptosis in inflamed fibroblasts, J. Dent. Res, 87, 51, 10.1177/154405910808700108

Yaegaki, 2008, Oral malodorous compound causes apoptosis and genomic DNA damage in human gingival fibroblasts, J. Periodontal. Res, 43, 391, 10.1111/j.1600-0765.2007.01052.x

Ramautar, 2009, CE-MS in metabolomics, Electrophoresis, 30, 276, 10.1002/elps.200800512

Ishii, 2007, Multiple high-throughput analyses monitor the response of E. coli to perturbations, Science, 316, 593, 10.1126/science.1132067

Ohashi, 2008, Depiction of metabolome changes in histidine-starved Escherichia coli by CE-TOFMS, Mol. BioSyst, 4, 135, 10.1039/B714176A

Soga, 2002, Simultaneous determination of anionic intermediates for Bacillus subtilis metabolic pathways by capillary electrophoresis electrospray ionization mass spectrometry, Anal. Chem, 74, 2233, 10.1021/ac020064n

Morohashi, 2007, Model based definition of population heterogeneity and its effects on metabolism in sporulating Bacillus subtilis, J. Biochem, 142, 183, 10.1093/jb/mvm121

Wu, 2010, Sampling methods for NMR-based metabolomics of Staphylococcus aureus, Biotechnol. J, 5, 75, 10.1002/biot.200900038

Garcia, 2008, Separation and mass spectrometry in microbial metabolomics, Curr. Opin. Microbiol, 11, 233, 10.1016/j.mib.2008.04.002

Hirayama, 2009, Quantitative metabolome profiling of colon and stomach cancer microenvironment by capillary electrophoresis time-of-flight mass spectrometry, Cancer Res, 69, 4918, 10.1158/0008-5472.CAN-08-4806

Rocha, 2010, Metabolic profiling of human lung cancer tissue by 1H high resolution magic angle spinning (HRMAS) NMR spectroscopy, J. Proteome. Res, 9, 319, 10.1021/pr9006574

Minami, 2009, Measurement of internal body time by blood metabolomics, Proc. Natl. Acad. Sci. USA, 106, 9890, 10.1073/pnas.0900617106

Connor, 2010, Integration of metabolomics and transcriptomics data to aid biomarker discovery in type 2 diabetes, Mol. Biosyst, 6, 909, 10.1039/b914182k

Want, 2010, Global metabolic profiling procedures for urine using UPLC-MS, Nat. Protoc, 5, 1005, 10.1038/nprot.2010.50

Soga, 2006, Differential metabolomics reveals ophthalmic acid as an oxidative stress biomarker indicating hepatic glutathione consumption, J. Biol. Chem, 281, 16768, 10.1074/jbc.M601876200

Yamada, 1975, Regulation of lactate dehydrogenase and change of fermentation products in streptococci, J. Bacteriol, 124, 55, 10.1128/jb.124.1.55-61.1975

Yamada, 1975, Glucose-6-phosphate-dependent pyruvate kinase in Streptococcus mutans, J. Bacteriol, 124, 562, 10.1128/jb.124.1.562-563.1975

Iwami, 1980, Rate-limiting steps of the glycolytic pathway in the oral bacteria Streptococcus mutans and Streptococcus sanguis and the influence of acidic pH on the glucose metabolism, Arch. Oral. Biol, 25, 163, 10.1016/0003-9969(80)90015-1

Abbe, 1982, Involvement of oxygen-sensitive pyruvate formate-lyase in mixed-acid fermentation by Streptococcus mutans under strictly anaerobic conditions, J. Bacteriol, 152, 175, 10.1128/jb.152.1.175-182.1982

Abbe, 1983, Purification and properties of pyruvate kinase from Streptococcus sanguis and activator specificity of pyruvate kinase from oral streptococci, Infect. Immun, 39, 1007, 10.1128/iai.39.3.1007-1014.1983

Iwami, 1985, Regulation of glycolytic rate in Streptococcus sanguis grown under glucose-limited and glucose-excess conditions in a chemo-stat, Infect. Immun, 50, 378, 10.1128/iai.50.2.378-381.1985

Hata, 1990, Biochemical mechanisms of enhanced inhibition of fluoride on the anaerobic sugar metabolism by Streptococcus sanguis, J. Dent. Res, 69, 1244, 10.1177/00220345900690060401

Takahashi, 1991, Metabolism of intracellular polysaccharide in the cells of Streptococcus mutans under strictly anaerobic conditions, Oral Microbiol. Immunol, 6, 299, 10.1111/j.1399-302X.1991.tb00497.x

Takahashi, 1992, Stimulatory effect of bicarbonate on the glycolysis of Actinomyces viscosus and its biochemical mechanism, Oral Microbiol. Immunol, 7, 165, 10.1111/j.1399-302X.1992.tb00530.x

Iwami, 1992, Acid production by streptococci growing at low pH in a chemostat under anaerobic conditions, Oral Microbiol. Immunol, 7, 304, 10.1111/j.1399-302X.1992.tb00593.x

Takahashi, 1999, Glucose and lactate metabolism by Actinomyces naeslundii, Crit. Rev. Oral Biol. Med, 10, 487, 10.1177/10454411990100040501

Iwami, 2000, Rate-limiting steps of glucose and sorbitol metabolism in Streptococcus mutans cells exposed to air, Oral Microbiol. Immunol, 15, 325, 10.1034/j.1399-302x.2000.150510.x

Miyasawa, 2003, Xylitol inhibition of anaerobic acid production by Streptococcus mutans at various pH levels, Oral Microbiol. Immunol, 18, 215, 10.1034/j.1399-302X.2003.00068.x

Kakuta, 2003, Xylitol inhibition of acid production and growth of mutans streptococci in the presence of various dietary sugars under strictly anaerobic conditions, Caries Res, 37, 404, 10.1159/000073391

Maehara, 2005, Synergistic inhibition by combination of fluoride and xylitol on glycolysis by mutans streptococci and its biochemical mechanism, Caries Res, 39, 521, 10.1159/000088190

Miyasawa-Hori, 2006, Difference in the xylitol sensitivity of acid production among Streptococcus mutans strains and the biochemical mechanism, Oral Microbiol Immunol, 21, 201, 10.1111/j.1399-302X.2006.00273.x

Takahashi, 2000, Metabolic pathways for cytotoxic end product formation from glutamate- and aspartate-containing peptides by Porphyromonas gingivalis, J. Bacteriol, 182, 4704, 10.1128/JB.182.17.4704-4710.2000

Soga, 2003, Quantitative metabolome analysis using capillary electrophoresis mass spectrome-try, J. Proteome. Res, 2, 488, 10.1021/pr034020m

Marsh, 1999, 34