Cerebrospinal fluid biomarkers of white matter lesions – cross‐sectional results from the LADIS study

European Journal of Neurology - Tập 17 Số 3 - Trang 377-382 - 2010
Michael Jonsson1, Henrik Zetterberg1, Elisabeth C.W. van Straaten2, K. Lind1, Steinar Syversen1, Åke Edman1, Kaj Blennow1, Lars Rosengren1, Leonardo Pantoni3, Serafina Valente3, Wiesje M. van der Flier1
1Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, The Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden
2Department of Neurology, Academisch Ziekenhuis Vrije Universiteit, Amsterdam, The Netherlands
3Department of Neurological and Psychiatric Sciences, University of Florence, Florence, Italy

Tóm tắt

Background and purpose:  White matter lesions (WMLs) caused by small vessel disease are common in elderly people and contribute to cognitive impairment. There are no established biochemical markers for WMLs. We aimed to study the relation between degree of WMLs rated on magnetic resonance imaging of the brain and cerebrospinal fluid (CSF) levels of structural biomarkers associated with Alzheimer’s disease (AD) and subcortical vascular dementia.Methods:  Fifty‐three non‐demented elderly individuals with WMLs were subjected to lumbar puncture. Degree of WMLs was rated using the Fazekas scale. Volumetric assessment of WMLs was performed. CSF samples were analyzed for the 40 and 42 amino acid fragments of amyloid β, α‐ and β‐cleaved soluble amyloid precursor protein, total tau (T‐tau), hyperphosphorylated tau (P‐tau181), neurofilament light protein (NFL), sulfatide and CSF/Serum‐albumin ratio.Results:  Fifteen subjects had mild, 23 had moderate and 15 had severe degree of WMLs. CSF‐NFL levels differed between the groups (P < 0.001) and correlated with the volume of WMLs (r = 0.477, P < 0.001). CSF sulfatide concentration displayed similar changes but less strongly. T‐tau, P‐tau181 and the different amyloid markers as well as CSF/S‐albumin ratio did not differ significantly between the groups.Conclusions:  The association of increased CSF‐NFL levels with increasing severity of WMLs in non‐demented subjects suggests that NFL is a marker for axonal damage in response to small vessel disease in the brain. This manifestation may be distinct from or earlier than the neurodegenerative process seen in AD, as reflected by the lack of association between WMLs and AD biomarkers.

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European Journal of Neurology

Tập 17 Số 3

377-382

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