Nội dung được dịch bởi AI, chỉ mang tính chất tham khảo
Bệnh lý mạch máu amyloid trong bệnh cơ thể Lewy
Tóm tắt
Trong khi bệnh Alzheimer và bệnh lý cơ thể Lewy được thảo luận như là các căn nguyên chính của chứng mất trí nhớ trong bệnh Parkinson (bệnh PD / bệnh cơ thể Lewy kiểu thân não), tác động và tỷ lệ mắc bệnh của bệnh lý mạch máu amyloid não (CAA) và mối liên hệ của nó với sự suy giảm nhận thức trong PD và chứng mất trí nhớ với cơ thể Lewy (DLB) vẫn chưa được biết đến. Mức độ nghiêm trọng của CAA và các tổn thương Alzheimer khác đã được đánh giá trong 68 trường hợp xác nhận qua khai thác tử thi PD, trong đó có 32 trường hợp bị mất trí nhớ (PDD), và 20 trường hợp DLB. Bệnh nhân PDD có độ tuổi trung bình cao hơn đáng kể so với những người không bị mất trí nhớ (tuổi trung bình 84,5 so với 77,6 tuổi; p < 0,01), tuổi trung bình của bệnh nhân DLB nằm giữa hai nhóm này (80,0 năm), trong khi thời gian mắc bệnh là DLB < PDD < PD (tuổi trung bình 6,5 so với 8,5 và 14,3 năm). Bệnh nhân PDD có giai đoạn Braak loạn dưỡng thần kinh cao hơn đáng kể (4,2 so với 2,4, p < 0,01), tải lượng amyloid β (Aβ) vỏ não cao hơn đáng kể, bệnh lý mạch máu amyloid não mao mạch (CapCAA) và CAA toàn thân cao hơn so với những người không bị mất trí nhớ (CapCAA nhẹ trong 22% so với CapCAA vừa đến nặng trong 87%; CAA toàn thân nhẹ trong 5,5% so với CAA toàn thân vừa đến nặng trong 82%). Giai đoạn PD trung bình cao hơn ở cả DLB và PDD so với PD (5,2 so với 4,5 và 4,0, tương ứng): Giai đoạn Braak loạn dưỡng thần kinh trung bình trong DLB là 3,4, tải lượng mảng Aβ nặng được thấy trong 95%, CapCAA vừa đến nặng trong 90% và CAA toàn thân từ nhẹ đến nặng trong 70%. Nghiên cứu này và các nghiên cứu gần đây khác ngụ ý rằng có sự liên kết giữa CAA với sự suy giảm nhận thức ở cả PD/PDD và DLB, đặc biệt là trong các trường hợp có bệnh lý Alzheimer đồng tồn tại.
Từ khóa
#bệnh Alzheimer #bệnh Parkinson #bệnh lý cơ thể Lewy #suy giảm nhận thức #bệnh lý mạch máu amyloid não (CAA)Tài liệu tham khảo
D Aarsland CG Ballard G Halliday (2004) ArticleTitleAre Parkinson’s disease with dementia and dementia with Lewy bodies the same entity? J Geriatr Psychiatry Neurol 17 137–145 Occurrence Handle15312277 Occurrence Handle10.1177/0891988704267470
D Aarsland R Perry A Brown JP Larsen C Ballard (2005a) ArticleTitleNeuropathology of dementia in Parkinson’s disease: a prospective, community-based study Ann Neurol 58 773–776 Occurrence Handle10.1002/ana.20635
D Aarsland J Zaccai C Brayne (2005b) ArticleTitleA systematic review of prevalence studies of dementia in Parkinson’s disease Mov Disord 20 1255–1263 Occurrence Handle10.1002/mds.20527
H Apaydin JE Ahlskog JE Parisi BF Boeve DW Dickson (2002) ArticleTitleParkinson disease neuropathology: later-developing dementia and loss of the levodopa response Arch Neurol 59 102–112 Occurrence Handle11790237 Occurrence Handle10.1001/archneur.59.1.102
J Attems KA Jellinger F Lintner (2005) ArticleTitleAlzheimer’s disease pathology influences severity and topographical distribution of cerebral amyloid angiopathy Acta Neuropathol (Berl) 110 222–231 Occurrence Handle10.1007/s00401-005-1064-y
J Attems M Quass KA Jellinger F Lintner (2007) ArticleTitleTopographical distribution of cerebral amyloid angiopathy and its effect on cognitive decline are influenced by Alzheimer’s disease pathology J Neurol Sci 257 49–55 Occurrence Handle17306303 Occurrence Handle10.1016/j.jns.2007.01.013
C Ballard I Ziabreva R Perry JP Larsen J O’Brien I McKeith E Perry D Aarsland (2006) ArticleTitleDifferences in neuropathologic characteristics across the Lewy body dementia spectrum Neurology 67 1931–1934 Occurrence Handle17159096 Occurrence Handle10.1212/01.wnl.0000249130.63615.cc Occurrence Handle1:STN:280:DC%2BD28jit1Kmtg%3D%3D
C Bancher R Egensperger S Kosel K Jellinger MB Graeber (1997) ArticleTitleLow prevalence of apolipoprotein E epsilon 4 allele in the neurofibrillary tangle predominant form of senile dementia Acta Neuropathol (Berl) 94 403–409 Occurrence Handle10.1007/s004010050726 Occurrence Handle1:CAS:528:DyaK2sXmslagtr4%3D
M Barrachina E Dalfo B Puig N Vidal M Freixes E Castano I Ferrer (2005) ArticleTitleAmyloid-beta deposition in the cerebral cortex in dementia with Lewy bodies is accompanied by a relative increase in AbetaPP mRNA isoforms containing the Kunitz protease inhibitor Neurochem Int 46 253–260 Occurrence Handle15670642 Occurrence Handle10.1016/j.neuint.2004.08.006 Occurrence Handle1:CAS:528:DC%2BD2MXmvFGgsg%3D%3D
J Bernacer L Prensa JM Gimenez-Amaya (2008) ArticleTitleChemical architecture of the posterior striatum in the human brain J Neural Transm 115 67–75 Occurrence Handle17726572 Occurrence Handle10.1007/s00702-007-0803-8 Occurrence Handle1:CAS:528:DC%2BD1cXhvFOjsw%3D%3D
Bertrand E, Lewandowska E, Pasennik E, Stepien T, Szpak GM, Dymecki J, Wierzba-Bobrowicz T (2007) Cerebral amyloid angiopathy in idiopathic Parkinson’s disease. Acta Neuropathol (in press)
IJ Bohr MA Ray JM McIntosh S Chalon D Guilloteau IG McKeith RH Perry F Clementi EK Perry JA Court MA Piggott (2005) ArticleTitleCholinergic nicotinic receptor involvement in movement disorders associated with Lewy body diseases. An autoradiography study using [(125)I]alpha-conotoxinMII in the striatum and thalamus Exp Neurol 191 292–300 Occurrence Handle15649484 Occurrence Handle10.1016/j.expneurol.2004.10.004 Occurrence Handle1:CAS:528:DC%2BD2MXksFKjtQ%3D%3D
JLW Bosboom D Stoffers EC Wolters (2004) ArticleTitleCognitive dysfunction and dementia in Parkinson’s disease J Neural Transm 111 1303–1315 Occurrence Handle15480840 Occurrence Handle10.1007/s00702-004-0168-1 Occurrence Handle1:STN:280:DC%2BD2crhtVKmsQ%3D%3D
H Braak E Braak (1991) ArticleTitleNeuropathological stageing of Alzheimer-related changes Acta Neuropathol (Berl) 82 239–259 Occurrence Handle10.1007/BF00308809 Occurrence Handle1:STN:280:DyaK387gtFOiug%3D%3D
H Braak K Del Tredici U Rub RA de Vos EN Jansen Steur E Braak (2003) ArticleTitleStaging of brain pathology related to sporadic Parkinson’s disease Neurobiol Aging 24 197–211 Occurrence Handle12498954 Occurrence Handle10.1016/S0197-4580(02)00065-9
H Braak U Rub EN Jansen Steur K Del Tredici RA de Vos (2005) ArticleTitleCognitive status correlates with neuropathologic stage in Parkinson’s disease Neurology 64 1404–1410 Occurrence Handle15851731 Occurrence Handle1:STN:280:DC%2BD2M3hsleruw%3D%3D
DJ Brooks P Piccini (2006) ArticleTitleImaging in Parkinson’s disease: the role of monoamines in behavior Biol Psychiatry 59 908–918 Occurrence Handle16581032 Occurrence Handle10.1016/j.biopsych.2005.12.017 Occurrence Handle1:CAS:528:DC%2BD28XksVOnuro%3D
DF Brown RC Risser EH Bigio P Tripp A Stiegler E Welch KP Eagan CL Hladik CL White Suffix3rd (1998) ArticleTitleNeocortical synapse density and Braak stage in the Lewy body variant of Alzheimer’s disease: a comparison with classic Alzheimer’s disease and normal aging J Neuropathol Exp Neurol 57 955–960 Occurrence Handle9786245 Occurrence Handle1:STN:280:DyaK1M%2FgtVWrtg%3D%3D
EJ Burton IG McKeith DJ Burn ED Williams JT O’Brien (2004) ArticleTitleCerebral atrophy in Parkinson’s disease with and without dementia: a comparison with Alzheimer’s disease, dementia with Lewy bodies and controls Brain 127 791–800 Occurrence Handle14749292 Occurrence Handle10.1093/brain/awh088
R Camicioli MM Moore A Kinney E Corbridge K Glassberg JA Kaye (2003) ArticleTitleParkinson’s disease is associated with hippocampal atrophy Mov Disord 18 784–790 Occurrence Handle12815657 Occurrence Handle10.1002/mds.10444
C Colosimo AJ Hughes L Kilford AJ Lees (2003) ArticleTitleLewy body cortical involvement may not always predict dementia in Parkinson’s disease J Neurol Neurosurg Psychiatry 74 852–856 Occurrence Handle12810766 Occurrence Handle10.1136/jnnp.74.7.852 Occurrence Handle1:STN:280:DC%2BD3s3otlOjsQ%3D%3D
T Del Ser V Hachinski H Merskey DG Munoz (2001) ArticleTitleClinical and pathologic features of two groups of patients with dementia with Lewy bodies: effect of coexisting Alzheimer-type lesion load Alzheimer Dis Assoc Disord 15 31–44 Occurrence Handle11236823 Occurrence Handle10.1097/00002093-200101000-00005 Occurrence Handle1:STN:280:DC%2BD3M3ksF2qsw%3D%3D
V Deramecourt S Bombois CA Maurage A Ghestem H Drobecq E Vanmechelen F Lebert F Pasquier A Delacourte (2006) ArticleTitleBiochemical staging of synucleinopathy and amyloid deposition in dementia with Lewy bodies J Neuropathol Exp Neurol 65 278–288 Occurrence Handle16651889 Occurrence Handle1:CAS:528:DC%2BD28Xkslegur0%3D
JE Duda (2004) ArticleTitlePathology and neurotransmitter abnormalities of dementia with Lewy bodies Dement Geriatr Cogn 17 IssueIDSuppl 1 3–14 Occurrence Handle10.1159/000074677 Occurrence Handle1:CAS:528:DC%2BD3sXpvVeksLs%3D
C Duyckaerts (2002) ArticleTitleIs Parkinson’s disease with dementia and dementia with Lewy body the same disease? Mov Disord 17 IssueIDSuppl 5 S9
M Emre (2003) ArticleTitleDementia associated with Parkinson’s disease Lancet Neurol 2 229–237 Occurrence Handle12849211 Occurrence Handle10.1016/S1474-4422(03)00351-X Occurrence Handle1:CAS:528:DC%2BD3sXkvVKqt70%3D
JA Feekes MD Cassell (2006) ArticleTitleThe vascular supply of the functional compartments of the human striatum Brain 129 2189–2201 Occurrence Handle16815876 Occurrence Handle10.1093/brain/awl158
M Fujita M Ichise SS Zoghbi JS Liow S Ghose DC Vines J Sangare JQ Lu VL Cropley H Iida KM Kim RM Cohen W Bara-Jimenez B Ravina RB Innis (2006) ArticleTitleWidespread decrease of nicotinic acetylcholine receptors in Parkinson’s disease Ann Neurol 59 174–177 Occurrence Handle16374823 Occurrence Handle10.1002/ana.20688 Occurrence Handle1:CAS:528:DC%2BD28Xpt1SksA%3D%3D
WR Galpern AE Lang (2006) ArticleTitleInterface between tauopathies and synucleinopathies: a tale of two proteins Ann Neurol 59 449–458 Occurrence Handle16489609 Occurrence Handle10.1002/ana.20819 Occurrence Handle1:CAS:528:DC%2BD28XjtV2lsbk%3D
JE Galvin J Pollack JC Morris (2006) ArticleTitleClinical phenotype of Parkinson disease dementia Neurology 67 1605–1611 Occurrence Handle17101891 Occurrence Handle10.1212/01.wnl.0000242630.52203.8f
T Gomez-Isla WB Growdon M McNamara K Newell E Gomez-Tortosa ET Hedley-Whyte BT Hyman (1999) ArticleTitleClinicopathologic correlates in temporal cortex in dementia with Lewy bodies Neurology 53 2003–2009 Occurrence Handle10599772 Occurrence Handle1:STN:280:DC%2BD3c%2Fms1Omtw%3D%3D
L Hansen D Salmon D Galasko E Masliah R Katzman R DeTeresa L Thal MM Pay R Hofstetter M Klauber et al. (1990) ArticleTitleThe Lewy body variant of Alzheimer’s disease: a clinical and pathologic entity Neurology 40 1–8 Occurrence Handle2153271 Occurrence Handle1:STN:280:DyaK3c7hsVKnsQ%3D%3D
Hansen LA (1997) The Lewy body variant of Alzheimer disease. J Neural Transm (Suppl 51): 83–93
AJ Harding GM Halliday (2001) ArticleTitleCortical Lewy body pathology in the diagnosis of dementia Acta Neuropathol (Berl) 102 355–363 Occurrence Handle1:CAS:528:DC%2BD3MXmsFWgs7w%3D
R Hilker AV Thomas JC Klein S Weisenbach E Kalbe L Burghaus AH Jacobs K Herholz WD Heiss (2005) ArticleTitleDementia in Parkinson’s disease: functional imaging of cholinergic and dopaminergic pathways Neurology 65 1716–1722 Occurrence Handle16344512 Occurrence Handle10.1212/01.wnl.0000191154.78131.f6 Occurrence Handle1:STN:280:DC%2BD2Mnmt1Ggtw%3D%3D
P Hobson J Meara (2004) ArticleTitleRisk and incidence of dementia in a cohort of older subjects with Parkinson’s disease in the United Kingdom Mov Disord 19 1043 Occurrence Handle15372593 Occurrence Handle10.1002/mds.20216
TA Hughes HF Ross RH Mindham EG Spokes (2004) ArticleTitleMortality in Parkinson’s disease and its association with dementia and depression Acta Neurol Scand 110 118–123 Occurrence Handle15242420 Occurrence Handle10.1111/j.1600-0404.2004.00292.x Occurrence Handle1:STN:280:DC%2BD2czjvF2ltg%3D%3D
HI Hurtig JQ Trojanowski J Galvin D Ewbank ML Schmidt VM Lee CM Clark G Glosser MB Stern SM Gollomp SE Arnold (2000) ArticleTitleAlpha-synuclein cortical Lewy bodies correlate with dementia in Parkinson’s disease Neurology 54 1916–1921 Occurrence Handle10822429 Occurrence Handle1:STN:280:DC%2BD3c3osVWhug%3D%3D
E Iseki T Togo K Suzuki O Katsuse W Marui R de Silva A Lees T Yamamoto K Kosaka (2003) ArticleTitleDementia with Lewy bodies from the perspective of tauopathy Acta Neuropathol (Berl) 105 265–270 Occurrence Handle1:CAS:528:DC%2BD3sXntV2htg%3D%3D
E Iseki (2004) ArticleTitleDementia with Lewy bodies: reclassification of pathological subtypes and boundary with Parkinson’s disease or Alzheimer’s disease Neuropathology 24 72–78 Occurrence Handle15068176 Occurrence Handle10.1111/j.1440-1789.2003.00530.x
KA Jellinger K Seppi GK Wenning W Poewe (2002) ArticleTitleImpact of coexistent Alzheimer pathology on the natural history of Parkinson’s disease J Neural Transm 109 329–339 Occurrence Handle11956955 Occurrence Handle10.1007/s007020200027 Occurrence Handle1:STN:280:DC%2BD383hvVCmtg%3D%3D
KA Jellinger (2003a) ArticleTitlePrevalence of vascular lesions in dementia with Lewy bodies. A postmortem study J Neural Transm 110 771–778 Occurrence Handle10.1007/s00702-003-0822-z Occurrence Handle1:STN:280:DC%2BD3s3otlKqsw%3D%3D
KA Jellinger (2003b) ArticleTitlePrevalence of cerebrovascular lesions in Parkinson’s disease. A postmortem study Acta Neuropathol (Berl) 105 415–419
KA Jellinger (2004) ArticleTitleLewy body-related alpha-synucleinopathy in the aged human brain J Neural Transm 111 1219–1235 Occurrence Handle15480835 Occurrence Handle10.1007/s00702-004-0138-7 Occurrence Handle1:CAS:528:DC%2BD2cXotFCrtbk%3D
KA Jellinger (2006) ArticleTitleThe morphological basis of mental dysfunction in Parkinson’s disease J Neurol Sci 248 167–172 Occurrence Handle16797594 Occurrence Handle10.1016/j.jns.2006.05.002 Occurrence Handle1:STN:280:DC%2BD28nkvVKisw%3D%3D
KA Jellinger (2007) ArticleTitleMorphological substrates of Parkinsonism with and without dementia. A retrospective clinico-pathological study J Neural Transm 72 IssueIDSuppl 91–107 Occurrence Handle10.1007/978-3-211-73574-9_12
KA Jellinger Y Mizuno (2003) Parkinson disease DW Dickson (Eds) Neurodegeneration: the molecular pathology of dementia and movement disorders ISN Neuropath Press Basel 159–199
KA Jellinger J Attems (2006a) ArticleTitleDoes striatal pathology distinguish Parkinson disease with dementia and dementia with Lewy bodies? Acta Neuropathol (Berl) 112 253–260 Occurrence Handle10.1007/s00401-006-0088-2
KA Jellinger J Attems (2006b) ArticleTitlePrevalence and impact of cerebrovascular pathology in Alzheimer’s disease and parkinsonism Acta Neurol Scand 114 38–46 Occurrence Handle10.1111/j.1600-0404.2006.00665.x Occurrence Handle1:STN:280:DC%2BD28zmtVamtw%3D%3D
KA Jellinger F Lauda J Attems (2007) ArticleTitleSporadic cerebral amyloid angiopathy is not a frequent cause of spontaneous brain hemorrhage Eur J Neurol 14 923–928 Occurrence Handle17662016 Occurrence Handle10.1111/j.1468-1331.2007.01880.x Occurrence Handle1:STN:280:DC%2BD2svksVensw%3D%3D
K Jendroska AJ Lees W Poewe SE Daniel (1996) ArticleTitleAmyloid beta-peptide and the dementia of Parkinson’s disease Mov Disord 11 647–653 Occurrence Handle8914090 Occurrence Handle10.1002/mds.870110609 Occurrence Handle1:STN:280:DyaK2s%2FntFWltw%3D%3D
V Kallhoff E Peethumnongsin H Zheng (2007) ArticleTitleLack of alpha-synuclein increases amyloid plaque accumulation in a transgenic mouse model of Alzheimer’s disease Mol Neurodegener 2 6 Occurrence Handle17367539 Occurrence Handle10.1186/1750-1326-2-6 Occurrence Handle1:CAS:528:DC%2BD2sXjsl2rur0%3D
E Kovari G Gold FR Herrmann A Canuto PR Hof C Bouras P Giannakopoulos (2003) ArticleTitleLewy body densities in the entorhinal and anterior cingulate cortex predict cognitive deficits in Parkinson’s disease Acta Neuropathol (Berl) 106 83–88
ML Kraybill EB Larson DW Tsuang L Teri WC McCormick JD Bowen WA Kukull JB Leverenz MM Cherrier (2005) ArticleTitleCognitive differences in dementia patients with autopsy-verified AD, Lewy body pathology, or both Neurology 64 2069–2073 Occurrence Handle15985574 Occurrence Handle10.1212/01.WNL.0000165987.89198.65 Occurrence Handle1:STN:280:DC%2BD2MzjsFSguw%3D%3D
AJ Lees (2002) ArticleTitleParkinson’s disease with dementia (PDD) is the same clinicopathological entity as dementia with Lewy bodies (DLB) (abstr) Mov Disord 17 IssueIDSuppl 5 S9
G Levy K Marder (2003) Prevalence, incidence, and risk factors for dementia in Parkinson’s disease M-A Bédard (Eds) Mental and behavioral dysfunction in movement disorders Humana Press Totowa, NJ 259–270 Occurrence Handle10.1385/1-59259-326-7:259
T Liang JV Noorigian JE Duda (2006) ArticleTitleDoes striatal pathology distinguish DLB from PDD? Mov Disord 21 IssueIDSuppl 13 S69–S70
CF Lippa TW Smith AM Saunders R Crook D Pulaski-Salo P Davies J Hardy AD Roses D Dickson (1995) ArticleTitleApolipoprotein E genotype and Lewy body disease Neurology 45 97–103 Occurrence Handle7824144 Occurrence Handle1:STN:280:DyaK2M7isVGksA%3D%3D
SM Lippa CF Lippa H Mori (2005) ArticleTitleAlpha-Synuclein aggregation in pathological aging and Alzheimer’s disease: the impact of beta-amyloid plaque level Am J Alzheimers Dis Other Demen 20 315–318 Occurrence Handle16273997 Occurrence Handle10.1177/153331750502000506
PK Mandal JW Pettegrew E Masliah RL Hamilton R Mandal (2006) ArticleTitleInteraction between Abeta peptide and alpha synuclein: molecular mechanisms in overlapping pathology of Alzheimer’s and Parkinson’s in dementia with Lewy body disease Neurochem Res 31 1153–1162 Occurrence Handle16947080 Occurrence Handle10.1007/s11064-006-9140-9 Occurrence Handle1:CAS:528:DC%2BD28XptlSmtLs%3D
FL Mastaglia CL Masters K Beyreuther BA Kakulas (1989) ArticleTitleDeposition of Alzheimer’s disease amyloid (A4) protein in the cerebral cortex in Parkinson’s disease Prog Clin Biol Res 317 475–484 Occurrence Handle2690109 Occurrence Handle1:STN:280:DyaK3c%2FpvFCqsA%3D%3D
FL Mastaglia RD Johnsen ML Byrnes BA Kakulas (2003) ArticleTitlePrevalence of amyloid-beta deposition in the cerebral cortex in Parkinson’s disease Mov Disord 18 81–86 Occurrence Handle12518303 Occurrence Handle10.1002/mds.10295
PM Mattila JO Rinne H Helenius DW Dickson M Roytta (2000) ArticleTitleAlpha-synuclein-immunoreactive cortical Lewy bodies are associated with cognitive impairment in Parkinson’s disease Acta Neuropathol (Berl) 100 285–290 Occurrence Handle10.1007/s004019900168 Occurrence Handle1:STN:280:DC%2BD3M%2FntVyitw%3D%3D
IG McKeith UP Mosimann (2004) ArticleTitleDementia with Lewy bodies and Parkinson’s disease Parkinsonism Relat Disord 10 IssueIDSuppl 1 S15–S18 Occurrence Handle15109582 Occurrence Handle10.1016/j.parkreldis.2003.12.005
IG McKeith D Galasko K Kosaka EK Perry DW Dickson LA Hansen DP Salmon J Lowe SS Mirra EJ Byrne G Lennox NP Quinn JA Edwardson PG Ince C Bergeron A Burns BL Miller S Lovestone D Collerton EN Jansen C Ballard RA de Vos GK Wilcock KA Jellinger RH Perry (1996) ArticleTitleConsensus guidelines for the clinical and pathologic diagnosis of dementia with Lewy bodies (DLB): report of the consortium on DLB international workshop Neurology 47 1113–1124 Occurrence Handle8909416 Occurrence Handle1:STN:280:DyaK2s%2FmsF2gtw%3D%3D
IG McKeith DW Dickson J Lowe M Emre JT O’Brien H Feldman J Cummings JE Duda C Lippa EK Perry D Aarsland H Arai CG Ballard B Boeve DJ Burn D Costa T Del Ser B Dubois D Galasko S Gauthier CG Goetz E Gomez-Tortosa G Halliday LA Hansen J Hardy T Iwatsubo RN Kalaria D Kaufer RA Kenny A Korczyn K Kosaka VM Lee A Lees I Litvan E Londos OL Lopez S Minoshima Y Mizuno JA Molina EB Mukaetova-Ladinska F Pasquier RH Perry JB Schulz JQ Trojanowski M Yamada (2005) ArticleTitleDiagnosis and management of dementia with Lewy bodies: third report of the DLB Consortium Neurology 65 1863–1872 Occurrence Handle16237129 Occurrence Handle10.1212/01.wnl.0000187889.17253.b1 Occurrence Handle1:STN:280:DC%2BD2Mnpt1GqsQ%3D%3D
RH Mindham (1999) ArticleTitleThe place of dementia in Parkinson’s disease: a methodologic saga Adv Neurol 80 403–408 Occurrence Handle10410748 Occurrence Handle1:STN:280:DyaK1MzjvV2gtQ%3D%3D
SS Mirra A Heyman D McKeel SM Sumi BJ Crain LM Brownlee FS Vogel JP Hughes G van Belle L Berg (1991) ArticleTitleThe consortium to establish a registry for Alzheimer’s disease (CERAD). Part II. Standardization of the neuropathologic assessment of Alzheimer’s disease Neurology 41 479–486 Occurrence Handle2011243 Occurrence Handle1:STN:280:DyaK3M7oslajsQ%3D%3D
A Nagano-Saito Y Washimi Y Arahata T Kachi JP Lerch AC Evans A Dagher K Ito (2005) ArticleTitleCerebral atrophy and its relation to cognitive impairment in Parkinson’s disease Neurology 64 224–229 Occurrence Handle15668417 Occurrence Handle1:STN:280:DC%2BD2M%2FktFSntg%3D%3D
E Noe K Marder KL Bell DM Jacobs JJ Manly Y Stern (2004) ArticleTitleComparison of dementia with Lewy bodies to Alzheimer’s disease and Parkinson’s disease with dementia Mov Disord 19 60–67 Occurrence Handle14743362 Occurrence Handle10.1002/mds.10633
J O’Brien D Ames I McKeith E Chiu (Eds) (2006) Dementia with Lewy bodies and Parkinson’s disease dementia Taylor & Francis London
JM Olichney LA Hansen D Galasko T Saitoh CR Hofstetter R Katzman LJ Thal (1996) ArticleTitleThe apolipoprotein E epsilon 4 allele is associated with increased neuritic plaques and cerebral amyloid angiopathy in Alzheimer’s disease and Lewy body variant Neurology 47 190–196 Occurrence Handle8710076 Occurrence Handle1:STN:280:DyaK283ptFSguw%3D%3D
JM Olichney RJ Ellis R Katzman MN Sabbagh L Hansen (1997) ArticleTitleTypes of cerebrovascular lesions associated with severe cerebral amyloid angiopathy in Alzheimer’s disease Ann NY Acad Sci 826 493–497 Occurrence Handle9329731 Occurrence Handle10.1111/j.1749-6632.1997.tb48511.x Occurrence Handle1:STN:280:DyaK2svntVeitg%3D%3D
S Papapetropoulos A Lieberman J Gonzalez DC Mash (2005) ArticleTitleCan Alzheimer’s type pathology influence the clinical phenotype of Parkinson’s disease? Acta Neurol Scand 111 353–359 Occurrence Handle15876335 Occurrence Handle10.1111/j.1600-0404.2005.00411.x Occurrence Handle1:STN:280:DC%2BD2M3jvFSjsA%3D%3D
MA Piggott EF Marshall N Thomas S Lloyd JA Court E Jaros D Burn M Johnson RH Perry IG McKeith C Ballard EK Perry (1999) ArticleTitleStriatal dopaminergic markers in dementia with Lewy bodies, Alzheimer’s and Parkinson’s diseases: rostrocaudal distribution Brain 122 IssueIDPt 8 1449–1468 Occurrence Handle10430831 Occurrence Handle10.1093/brain/122.8.1449
MA Piggott J Owens J O’Brien S Colloby J Fenwick D Wyper E Jaros M Johnson RH Perry EK Perry (2003) ArticleTitleMuscarinic receptors in basal ganglia in dementia with Lewy bodies, Parkinson’s disease and Alzheimer’s disease J Chem Neuroanat 25 161–173 Occurrence Handle12706204 Occurrence Handle10.1016/S0891-0618(03)00002-4 Occurrence Handle1:CAS:528:DC%2BD3sXivFCqu70%3D
MA Piggott CG Ballard E Rowan C Holmes IG McKeith E Jaros RH Perry EK Perry (2007) ArticleTitleSelective loss of dopamine D2 receptors in temporal cortex in dementia with Lewy bodies, association with cognitive decline Synapse 61 903–911 Occurrence Handle17663455 Occurrence Handle10.1002/syn.20441 Occurrence Handle1:CAS:528:DC%2BD2sXhtFaiu7fI
O Pletnikova N West MK Lee GL Rudow RL Skolasky TM Dawson L Marsh JC Troncoso (2005) ArticleTitleAbeta deposition is associated with enhanced cortical alpha-synuclein lesions in Lewy body diseases Neurobiol Aging 26 1183–1192 Occurrence Handle15917102 Occurrence Handle10.1016/j.neurobiolaging.2004.10.006 Occurrence Handle1:CAS:528:DC%2BD2MXks1CntLs%3D
DR Premkumar DL Cohen P Hedera RP Friedland RN Kalaria (1996) ArticleTitleApolipoprotein E-epsilon4 alleles in cerebral amyloid angiopathy and cerebrovascular pathology associated with Alzheimer’s disease Am J Pathol 148 2083–2095 Occurrence Handle8669492 Occurrence Handle1:STN:280:DyaK283jsVaqsg%3D%3D
IH Richard M Papka A Rubio R Kurlan (2002) ArticleTitleParkinson’s disease and dementia with Lewy bodies: one disease or two? Mov Disord 17 1161–1165 Occurrence Handle12465052 Occurrence Handle10.1002/mds.10274
Y Saito A Kawashima NN Ruberu H Fujiwara S Koyama M Sawabe T Arai H Nagura H Yamanouchi M Hasegawa T Iwatsubo S Murayama (2003) ArticleTitleAccumulation of phosphorylated alpha-synuclein in aging human brain J Neuropathol Exp Neurol 62 644–654 Occurrence Handle12834109 Occurrence Handle1:CAS:528:DC%2BD3sXlt1yqu78%3D
W Samuel D Galasko E Masliah LA Hansen (1996) ArticleTitleNeocortical lewy body counts correlate with dementia in the Lewy body variant of Alzheimer’s disease J Neuropathol Exp Neurol 55 44–52 Occurrence Handle8558171 Occurrence Handle1:STN:280:DyaK287js1WmtA%3D%3D
C Summerfield C Junque E Tolosa P Salgado-Pineda B Gomez-Anson MJ Marti P Pastor B Ramirez-Ruiz J Mercader (2005) ArticleTitleStructural brain changes in Parkinson’s disease with dementia: a voxel-based morphometry study Arch Neurol 62 281–285 Occurrence Handle15710857 Occurrence Handle10.1001/archneur.62.2.281
DR Thal U Rub C Schultz I Sassin E Ghebremedhin K Del Tredici E Braak H Braak (2000) ArticleTitleSequence of Abeta-protein deposition in the human medial temporal lobe J Neuropathol Exp Neurol 59 733–748 Occurrence Handle10952063 Occurrence Handle1:CAS:528:DC%2BD3cXmtlekur8%3D
A Thomas C Ballard RA Kenny J O’Brien A Oakley R Kalaria (2005) ArticleTitleCorrelation of entorhinal amyloid with memory in Alzheimer’s and vascular but not Lewy body dementia Dement Geriatr Cogn 19 57–60 Occurrence Handle10.1159/000082349 Occurrence Handle1:CAS:528:DC%2BD2MXht1ymsrY%3D
D Trembath JF Ervin L Broom M Szymanski K Welsh-Bohmer C Pieper CM Hulette (2007) ArticleTitleThe distribution of cerebrovascular amyloid in Alzheimer’s disease varies with ApoE genotype Acta Neuropathol (Berl) 113 23–31 Occurrence Handle10.1007/s00401-006-0162-9 Occurrence Handle1:CAS:528:DC%2BD28Xht1entLfL
Y Tsuboi DW Dickson (2005) ArticleTitleDementia with Lewy bodies and Parkinson’s disease with dementia: are they different? Parkinsonism Relat Disord 11 IssueIDSuppl 1 S47–S51 Occurrence Handle15885629 Occurrence Handle10.1016/j.parkreldis.2004.10.014
H Uchikado E Iseki K Tsuchiya T Togo O Katsuse K Ueda M Kato K Kosaka (2002) ArticleTitleDementia with Lewy bodies showing advanced Lewy pathology but minimal Alzheimer pathology-Lewy pathology causes neuronal loss inducing progressive dementia Clin Neuropathol 21 269–277 Occurrence Handle12489676 Occurrence Handle1:STN:280:DC%2BD38jis12msQ%3D%3D
GK Wenning KA Jellinger (2005) ArticleTitleThe role of alpha-synuclein and tau in neurodegenerative movement disorders Curr Opin Neurol 18 357–362 Occurrence Handle16003109 Occurrence Handle10.1097/01.wco.0000168241.53853.32 Occurrence Handle1:CAS:528:DC%2BD2MXps1KktL4%3D
E Wu RB Lipton DW Dickson (1992) ArticleTitleAmyloid angiopathy in diffuse Lewy body disease Neurology 42 2131–2135 Occurrence Handle1436523 Occurrence Handle1:STN:280:DyaK3s%2Fmtl2isg%3D%3D
DJ Zgaljardic NS Foldi JC Borod (2004) ArticleTitleCognitive and behavioral dysfunction in Parkinson’s disease: neurochemical and clinicopathological contributions J Neural Transm 111 1287–1303 Occurrence Handle15480839 Occurrence Handle10.1007/s00702-004-0178-z Occurrence Handle1:STN:280:DC%2BD2crhtVKmsA%3D%3D
I Ziabreva CG Ballard D Aarsland JP Larsen IG McKeith RH Perry EK Perry (2006) ArticleTitleLewy body disease: thalamic cholinergic activity related to dementia and parkinsonism Neurobiol Aging 27 433–438 Occurrence Handle15913843 Occurrence Handle10.1016/j.neurobiolaging.2005.02.004 Occurrence Handle1:CAS:528:DC%2BD28XhtlCms74%3D