Cellular senescence and autophagy of myoepithelial cells are involved in the progression of in situ areas of carcinoma ex-pleomorphic adenoma to invasive carcinoma. An in vitro model

Altemani A, Martins MT, Freitas L, Soares F, Araújo NS, Araújo VC (2005) Carcinoma ex pleomorphic adenoma (CXAP): immunoprofile of the cells involved in carcinomatous progression. Histophatology 46:635–641

Araújo VC, Altemani A, Furuse C, Martins MT, Araújo NS (2006) Immunoprofile of reatctive salivary myoepithelial cells in intraductal áreas of carcinoma ex-pleomorphic adenoma. Oral Oncol 42:1011–1116

Barsky SH, Karlin NJ (2005) Myoepithelial cells: autocrine and paracrine suppressors of breast cancer progression. J Mammary Gland Biol Neoplasia 10:249–260

Bartlett JM, Nofech-Moses S, Rakovitch E (2014) Ductal carcinoma in situ of the breast: can biomarkers improve current management? Clin Chem 60:60–67

Campisi J (2011) Cellular senescence: putting the paradoxes in perspective. Curr Opin Genet Dev 21:107–112

Campisi J, Fagagna FDA (2007) Cellular senescence: when bad things happen to good cells. Nat Rev Mol Cell Biol 8:729–740

Campisi J, Andersen JK, Kapahi P, Melov S (2011) Cellular senescence: a link between cancer and age-related degenerative disease? Semin Cancer Biol 21:354–359

Cao Y, Klionsky DJ (2007) Physiological functions of Atg6/Beclin-1: a unique autophagy-related protein. Cell Res 17:839–849

Capparelli C, Chiavarina B, Whitaker-Menezes D, Pestell TG, Pestell RG, Hulit J et al (2012a) CDK inibitors (p16/p19/p21) induce senescence and autophagy in cancer-associated fibroblasts, “fueling” tumor growth via paracrine interactions, wihout an increase in neo-angiogenesis. Cell Cycle 11:3599–3610

Capparelli C, Guido C, Whitaker-Menezes D, Bonuccelli G, Balliet R, Pestell TG et al (2012b) Autophagy and senescence in cancer-associated fibroblasts metabolically supports tumor growth and metastasis via glycolysis and ketone production. Cell Cycle 11:2285–2302

Capparelli C, Whitaker-Menezes D, Guido C, Balliet R, Pestell TG, Howell A et al (2012c) CTGF drives autophagy, glycolysis and senescence in cancer-associated fibroblasts via HIF1 activation, metabolically promoting tumor growth. Cell Cycle 11:2272–2284

Chen J, Goligorsky MS (2006) Premature senescence of endothelial cells: methusaleh’s dilemma. Am J Physiol Heart Circ Physiol 290:729–739

Chen N, Karantza-Wadsworth V (2009) Role and regulation of autophagy in cancer. Biochim Biophys Acta 1793:1516–1523

Chen J, Xavier S, Moskowitz-Kassai E, Chen R, Lu CY, Sanduski K et al (2012) Cathepsin cleavage of sirtuin 1 in endothelial progenitor cells mediates stress-induced premature senescence. Am J Pathol 180:973–983

Cheung CHA, Cheng LT, Chang KY, Chen HH, Chang JY (2011) Investigations of surviving: the past, present and future. Front Biosci 16:952–961

Cowell CF, Weigelt B, Sakr RA, Ng CK, Hicks J, King TA, Reis-Filho JS (2013) Progression from ductal carcinoma in situ to invasive breast cancer: revisited. Mol Oncol 7:859–869

Dimri GP (2005) What has senescence got to do with cancer? Cancer Cell 7:505–512

Dulic V (2013) Senescence regulation by mTOR. Methods Mol Biol 965:15–35

Evan GI, Fagagna FDA (2009) Cellular senescence: hot or what? Curr Opin Genet Dev 19:25–31

Jones JL, Shaw JA, Pringle JH, Walker RA (2003) Primary breast myoepithelial cells exert an invasion-supressor effect on breast cancer cells via paracrine down-regulation of MMP expression in fibroblasts and tumour cells. J Pathol 201:562–572

Kondo Y, Kanzawa T, Sawaya R, Kondo S (2005) The role of autophagy in cancer development and response to therapy. Nat Rev Cancer 5:726–733

Larsson LG (2011) Oncogene and tumor suppressor gene-mediated suppression of cellular senescence. Semin Cancer Biol 21:367–376

Levine B (2007) Autophagy and cancer. Cell Biol 446:745–747

Martinez EF, Demasi AP, Miguita L, Altemani A, Araújo NS, Araújo VC (2010) FGF-2 is overexpressed in myoepithelial cells of carcinoma ex-pleomorphic adenoma in situ structures. Oncol Rep 24:155–160

Martinez EF, Montaldi PT, Araújo NS, Altemani A, Araújo VC (2012) A proposal of an in vitro model which mimics in situ áreas of carcinoma. J Cell Comun Signal 6:107–109

Martinez EF, Napimoga MH, Montalli VA, de Araújo NS, de Araújo VC (2013) In vitro cytokine expression in in situ-like areas of malignant neoplasia. Arch Oral Biol 58:552–557

Metwaly H, Maruyama S, Yamazaki M, Tsuneki M, Abé T, Jen KY et al (2012) Parenchymal-stromal switching for extracellular matrix production on invasion of oral squamous cell carcinoma. Hum Pathol 43:1973–1981

Miguita L, Martinez EF, Araújo NS, Araújo VC (2010) FGF-2, TGFß-1, PDGF-A and respective receptors expression in pleomorphic adenoma myoepithelial cells: an in vivo and in vitro study. J Appl Oral Sci 18:83–91

Miracco C, Meng GC, Franchi A, Luzi P, Cosci E, Mourmouras V et al (2010) Beclin-1 and LC3 autophagic gene expression. In cutaneous melanocytic lesions. Hum Pathol 41:503–512

Narita M, Young AR, Narita M (2009) Autophagy facilitates oncogene-induced senescence. Autophagy 5:1046–1047

Nguyen M, Lee MC, Wang JL, Tomlinson JS, Shao ZM, Alpaugh ML et al (2000) The human myoepithelial cells displays a multifaceted anti-angiogenic phenotype. Oncogene 19:3449–3459

Ouyang L, Shi Z, Zhao S, Wang FT, Zhou TT, Liu B et al (2012) Programmed cell death pathways in cancer: a review of apoptosis, autophagy and programmed necrosis. Cell Prolif 45:487–498

Pattingre S, Espert L, Biard-Piechaczyk M, Codogno P (2008) Regulation of macroautophagy by mTOR and Beclin 1 complexes. Biochimie 90:313–323

Placzek WJ, Wei J, Kitada S, Zhai D, Reed JC, Pellecchia M (2010) A survey of the anti-apoptotic Bcl-2 subfamily expression in cancer types provides a platform to predict the efficacy of Bcl-2 antagonists in cancer therapy. Cell Death Dis 1:e40

Plati J, Bucur O, Khosravi-Far R (2011) Apoptotic cell signaling in câncer progression and therapy. Integr Biol 3:279–296

Roberg K, Jonsson AC, Grénman R, Norberg-Spaak L (2007) Radiotherapy response in oral squamous carcinoma cell lines: evaluation of apoptotic proteins as prognostic factors. Head Neck 29:325–334

Roy S, Debnath J (2010) Autophagy and tumorigenesis. Semin Immunopathol 32:383–396

Shao ZM, Nguyen M, Alpaugh ML, O’Connell JT, Barsky SH (1998) The human myoepithelial cell exerts antiproliferative effects on breast carcinoma cells characterized by p21 induction, G2/M arrest, and apoptosis. Exp Cell Res 241:394–403

Shay JW, Roninson IB (2004) Hallmarks of senescence in carcinogenesis and cancer therapy. Oncogene 23:2919–2933

Silva AD, Silva CAB, Montalli VA, Martinez EF, Araújo VC, Furuse C (2012) In vitro evaluation of the suppressor potential of conditioned medium from benign myoepithelial cells from pleomorphic adenoma in malignant cell invasion. J Oral Pathol Med 41:610–614

Sternlicht MD, Barsky SH (1997) The myoepithelial defense: a host defense against câncer. Med Hypotheses 48:37–46

Sternlicht MD, Kedeshian P, Shao ZM, Safarians S, Barsky SH (1997) The human myoepithelial cells is a natural tumor suppressor. Clin Cancer Res 3:1949–1958

Townson JL, Naumov GN, Chambers AF (2003) The role of apoptosis in tumor progression and metastasis. Curr Mol Med 3:631–642

Ulukaya E, Acilan C, Yilmaz Y (2011) Apoptosis: why and how does it occur in biology? Cell Biochem Funct 29:468–480

Wong RSY (2011) Apoptosis in cancer: from pathogenesis to treatment. J Exp Clin Cancer Res 30:87–100