Amit Zeisel1, Ana B. Muñoz‐Manchado1, Simone Codeluppi1, Peter Lönnerberg1, Gioele La Manno1, Anna Juréus1, Sueli Marques1, Hermany Munguba1, Liqun He2, Christer Betsholtz2,3, Charlotte Rolny4, Gonçalo Castelo‐Branco1, Jens Hjerling‐Leffler1, Sten Linnarsson1
1Division of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, S-171 77 Stockholm, Sweden.
2Department of Immunology, Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Dag Hammarskjölds väg 20, S-751 85 Uppsala, Sweden.
3Division of Vascular Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, S-171 77 Stockholm, Sweden.
4Department of Oncology-Pathology, Karolinska Institutet, S-171 76 Stockholm, Sweden.
Tóm tắt
Cellular diversity in the brain revealed
The mammalian brain has an extraordinarily large number of cells. Although there are quite a few different cell types, many cells in any one category tend to look alike. Zeisel
et al.
analyzed the transcriptomes of mouse brain cells to reveal more than meets the eye. Interneurons of similar type were found in dissimilar regions of the brain. Oligodendrocytes that seemed to be all of one class were differentiated by their molecular signatures into a half-dozen classes. Microglia associated with blood vessels were distinguished from look-alike perivascular macrophages. Thus, the complex microanatomy of the brain can be revealed by the RNAs expressed in its cells.
Science
, this issue p.
1138
