Causal analysis approaches in Ingenuity Pathway Analysis

Bioinformatics (Oxford, England) - Tập 30 Số 4 - Trang 523-530 - 2014
A. Krämer1, Jeff Green1, Jack Pollard1, Stuart Tugendreich1
11 Ingenuity Systems, 1700 Seaport Boulevard, Redwood City, CA and 2Translational and Experimental Medicine—Bioinformatics, Sanofi-Aventis, 270 Albany Street, Cambridge, MA, USA

Tóm tắt

Abstract Motivation: Prior biological knowledge greatly facilitates the meaningful interpretation of gene-expression data. Causal networks constructed from individual relationships curated from the literature are particularly suited for this task, since they create mechanistic hypotheses that explain the expression changes observed in datasets. Results: We present and discuss a suite of algorithms and tools for inferring and scoring regulator networks upstream of gene-expression data based on a large-scale causal network derived from the Ingenuity Knowledge Base. We extend the method to predict downstream effects on biological functions and diseases and demonstrate the validity of our approach by applying it to example datasets. Availability: The causal analytics tools ‘Upstream Regulator Analysis', ‘Mechanistic Networks', ‘Causal Network Analysis' and ‘Downstream Effects Analysis' are implemented and available within Ingenuity Pathway Analysis (IPA, http://www.ingenuity.com). Supplementary information:  Supplementary material is available at Bioinformatics online.

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Thông tin xuất bản

Bioinformatics (Oxford, England)

Tập 30 Số 4

523-530

Thông tin tác giả