Caspases: Enemies Within

American Association for the Advancement of Science (AAAS) - Tập 281 Số 5381 - Trang 1312-1316 - 1998
Nancy A. Thornberry1, Yuri Lazebnik1
1N. A. Thornberry is in the Department of Biochemistry, Merck Research Laboratories, R80W-250, Post Office Box 2000, Rahway, NJ 07065, USA. Y. Lazebnik is at Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, NY 11724, USA.

Tóm tắt

REVIEW Apoptosis, an evolutionarily conserved form of cell suicide, requires specialized machinery. The central component of this machinery is a proteolytic system involving a family of proteases called caspases. These enzymes participate in a cascade that is triggered in response to proapoptotic signals and culminates in cleavage of a set of proteins, resulting in disassembly of the cell. Understanding caspase regulation is intimately linked to the ability to rationally manipulate apoptosis for therapeutic gain.

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Y.L. is a Pew Scholar. We thank D. Vanderwall for help in preparing Fig. 1B. Because of space limitations it was not possible to include a comprehensive list of references for all of the work discussed.