Carrier-Mediated Intestinal Transport of Drugs

citation_journal_title=Japn. J. Phys.; citation_title=Proton-coupled transport of organic solutes in animal cell membranes and its relation to Na+ transport; citation_author=T. Hoshi.; citation_volume=35; citation_publication_date=1985; citation_pages=179-191; citation_id=CR1 citation_journal_title=Gut; citation_title=Determination of acid surface pH in vivo in rat proximal jejunum; citation_author=M. Lucus.; citation_volume=24; citation_publication_date=1983; citation_pages=734-739; citation_id=CR2 citation_journal_title=Biochem. J.; citation_title=Sodium/proton antiport in brush-border membrane vesicles isolated from rat small intestine and kidney; citation_author=H. Murer, U. Hopfer, R. Kinne.; citation_volume=154; citation_publication_date=1976; citation_pages=597-604; citation_id=CR3 citation_title=Intestinal transport of amino acids and peptides; citation_inbook_title=Physiology of the gastrointestinal tract; citation_publication_date=1994; citation_pages=1773-1794; citation_id=CR4; citation_author=V. Ganapathy; citation_author=M. Brandsch; citation_author=F. H. Leibach.; citation_publisher=Raven Press citation_journal_title=Meth. Enzymol.; citation_title=Distinguishing amino acid transport systems of a given cell or tissue; citation_author=H. N. Christensen.; citation_volume=173; citation_publication_date=1989; citation_pages=576-616; citation_id=CR5 citation_journal_title=Biochim. Biophys. Acta; citation_title=Chloride-dependence of amino acid transport in rabbit ileum; citation_author=L. K. Munck, B. G. Munck.; citation_volume=1027; citation_publication_date=1990; citation_pages=17-20; citation_id=CR6 citation_journal_title=Am. J. Physiol.; citation_title=Active transport of taurine in rabbit jejunal brush-border membrane vesicles; citation_author=Y. Miyamoto, C. Tirrupathi, V. Ganapathy, F. H. Leibach. ; citation_volume=257; citation_publication_date=1989; citation_pages=G65-G72; citation_id=CR7 citation_journal_title=Biochim. Biophys. Acta; citation_title=H+-coupled α-methylaminoisobutyric acid transport in human intestinal Caco-2 cells; citation_author=D. T. Thwaites, G. T. A. McEwan, B. H. Hirst, N. L. Simmons. ; citation_volume=1234; citation_publication_date=1995; citation_pages=111-118; citation_id=CR8 citation_journal_title=J. Physiol.; citation_title=Mammalian ion-coupled solute transporters; citation_author=M. A. Hediger, Y. Kanai, G. You, S. Nussberger.; citation_volume=482; citation_publication_date=1995; citation_pages=7S-17S; citation_id=CR9 citation_journal_title=Pharm. Res.; citation_title=A saturable transport mechanism in the intestinal absorption of gabapentin is the underlying cause of the lack of proportionality between increasing dose and drug levels in plasma; citation_author=B. H. Stewart, A. R. Kugler, P. R. Thompson, N. Bockbrader. ; citation_volume=10; citation_publication_date=1993; citation_pages=276-281; citation_id=CR10 citation_journal_title=J. Pharm. Pharmacol.; citation_title=Concentration and pH dependency of α-methyldopa absorption in rat intestine; citation_author=G. L. Amidon, A. E. Merfeld, J. B. Dressman.; citation_volume=38; citation_publication_date=1986; citation_pages=363-368; citation_id=CR11 citation_journal_title=Pharm. Res.; citation_title=Mechanism of L-α-methyldopa transport through a monolayer of polarized human intestinal epithelial cells (Caco-2); citation_author=M. Hu, R. T. Borchardt.; citation_volume=7; citation_publication_date=1990; citation_pages=1313-1319; citation_id=CR12 citation_journal_title=Chem. Pharm. Bull (Tokyo); citation_title=Studies on the metabolism of D-and L-isomers of 3,4-dihydroxyphenylalanine (DOPA). V. Mechanism of intestinal absorption of D-and L-DOPA-14C in rats; citation_author=H. Shindo, T. Komai, K. Kawai.; citation_volume=21; citation_publication_date=1973; citation_pages=2031-2038; citation_id=CR13 citation_journal_title=Biopharm. Drug Dispos.; citation_title=Influence of leucine on intestinal baclofen absorption as a model compound of neutral α-amino acids; citation_author=T. Cercos-Fortea, A. Polache, A. Nacher, E. Cejudo-Ferragud, V. G. Casabo, M. Merino.; citation_volume=16; citation_publication_date=1995; citation_pages=563-577; citation_id=CR14 citation_journal_title=Brit. J. Pharmacol.; citation_title=D-cycloserine transport in human intestinal epithelial (Caco-2) cells mediated by a H+-coupled amino acid transporter; citation_author=D. T. Thwaites, G. Armstrong, B. H. Hirst, N. L. Simmons. ; citation_volume=115; citation_publication_date=1995; citation_pages=761-766; citation_id=CR15 citation_journal_title=Am. J. Physiol.; citation_title=Is intestinal peptide transport energized by a proton gradient?; citation_author=V. Ganapathy, F. H. Leibach.; citation_volume=249; citation_publication_date=1985; citation_pages=G153-G160; citation_id=CR16 citation_journal_title=Gastroenterology; citation_title=Characteristics and mechanism of glutamine-dipeptide absorption in human intestine; citation_author=H. Minami, E. L. Morse, S. A. Adibi.; citation_volume=103; citation_publication_date=1992; citation_pages=3-11; citation_id=CR17 citation_journal_title=Nature; citation_title=Expression cloning of a mammalian proton-coupled oligopeptide transporter; citation_author=Y.-J. Fei, Y. Kanai, S. Nussberger, V. Ganapathy, F. H. Leibach, M. F. Romero, S. K. Singh, W. F. Boron, M. A. Hediger. ; citation_volume=368; citation_publication_date=1994; citation_pages=563-566; citation_doi=10.1038/368563a0; citation_id=CR18 citation_journal_title=J. Biol. Chem.; citation_title=Human intestinal H+/peptide cotransporter. Cloning, functional expression, and chromosomal localization; citation_author=R. Liang, Y.-J. Fei, P. D. Presad, S. Ramamoorthy, H. Han, T. L. Yang-Feng, M. A. Hediger, V. Ganapathy, F. H. Leibach. ; citation_volume=270; citation_publication_date=1995; citation_pages=6456-6463; citation_id=CR19 citation_journal_title=Biochem. Biophys. Acta; citation_title=Sequence, tissue distribution and developmental changes in rat intestinal oligopeptide transporter; citation_author=K. Miyamoto, T. Shiraga, H. Yamamoto, H. Haga, Y. Taketani, K. Morita, I. Tamai, Y. Sai, A. Tsuji, E. Takeda.; citation_volume=1305; citation_publication_date=1996; citation_pages=34-38; citation_id=CR20 I. Tamai, K. Hayashi, T. Terao, Y. Sai, T. Shiraga, K. Miyamoto, E. Takeda, H. Higashida, and A. Tsuji. H+ coupled transport of β-lactam antibiotics mediated by oligopeptide transporter, PepT1, cloned from rat small intestine. submitted. citation_journal_title=Biochem. J.; citation_title=Glycyl-L-proline transport in rabbit enterocyte basolateral membrane vesicles; citation_author=J. Dyer, R. B. Beechey, J.-P. Gorvel, R. T. Smith, R. Wootton, S. P. Shirazi-Beechey.; citation_volume=269; citation_publication_date=1990; citation_pages=565-571; citation_id=CR22 citation_journal_title=J. Biol. Chem.; citation_title=Transepithelial glycylsarcosine transport in intestinal Caco-2 cells mediated by expression of H+-coupled carriers at both apical and basal membranes; citation_author=D. T. Thwaites, C. D. A. Brown, B. H. Hirst, N. L. Simmons. ; citation_volume=268; citation_publication_date=1993; citation_pages=7640-7642; citation_id=CR23 citation_journal_title=Biochim. Biophys. Acta; citation_title=Molecular cloning of PEPT 2, a new member of the H+/peptide cotransport family, from human kidney; citation_author=W. Liu, R. Liang, S. Ramamoorthy, Y-J. Fei, M. E. Ganapathy, M. A. Hediger, V. Ganapathy, F. H. Leibach.; citation_volume=1235; citation_publication_date=1995; citation_pages=461-466; citation_id=CR24 citation_title=Intestinal absorption of β-lactam antibiotics; citation_inbook_title=Peptide-based drug design; citation_publication_date=1995; citation_pages=299-316; citation_id=CR25; citation_author=A. Tsuji.; citation_publisher=American Chemical Society citation_journal_title=J. Biol. Chem.; citation_title=H+ copuled uphill transport of aminocephalosporins via the dipeptide transport system in rabbit intestinal brush-border membranes; citation_author=T. Okano, K. Inui, H. Maegawa, M. Takano, R. Hori.; citation_volume=261; citation_publication_date=1986; citation_pages=14130-14134; citation_id=CR26 citation_journal_title=J. Pharmacol. Exp. Ther.; citation_title=Transepithelial transport of oral cephalosporins by monolayers of intestinal epithelial cell line Caco-2: Specific transport systems in apical and basolateral membranes; citation_author=K. Inui, M. Miyamoto, H. Saito.; citation_volume=261; citation_publication_date=1992; citation_pages=195-201; citation_id=CR27 citation_journal_title=Biochem. Pharmacol.; citation_title=Functional expression of intestinal depeptide/β-lactam antibiotic transporter in Xenopus laevis oocytes; citation_author=I. Tamai, N. Tomizawa, A. Kadowaki, T. Terasaki, K. Nakayama, H. Higashida, A. Tsuji.; citation_volume=48; citation_publication_date=1994; citation_pages=881-888; citation_id=CR28 citation_journal_title=J. Pharmacol. Exp. Ther.; citation_title=Functional expression of transporter for β-lactam antibiotics and dipeptides in Xenopus laevis oocytes injected with messenger RNA from human, rat and rabbit small intestines; citation_author=I. Tamai, N. Tomizawa, T. Takeuchi, K. Nakayama, H. Higashida, A. Tsuji.; citation_volume=273; citation_publication_date=1995; citation_pages=26-31; citation_id=CR29 citation_journal_title=Pflugers-Arch.; citation_title=Expression cloning of a cDNA from rabbit small intestine related to proton-coupled transport of peptides, β-lactam antibiotics and ACE-inhibitors; citation_author=M. Boll, D. Markovich, W.-M. Weber, H. Korter, H. Daniel, H. Murer.; citation_volume=429; citation_publication_date=1994; citation_pages=146-149; citation_id=CR30 citation_journal_title=Annu. Rev. Pharmacol. Toxicol.; citation_title=Absorption of peptide and peptidomimetic drugs; citation_author=G. L. Amidon, H. J. Lee.; citation_volume=34; citation_publication_date=1994; citation_pages=321-341; citation_id=CR31 citation_title=Oral absorption of angiotensin-converting enzyme inhibitors and peptide prodrugs; citation_inbook_title=Peptide-based drug design; citation_publication_date=1995; citation_pages=299-316; citation_id=CR32; citation_author=S. Yee; citation_author=G. L. Amidon.; citation_publisher=American Chemical Society citation_journal_title=Biochim. Biophys. Acta; citation_title=Interaction of renin inhibitors with the intestinal uptake system for oligopeptides and β-lactam antibiotics; citation_author=W. Kramer, F. Girbig, U. Gutjahr, H. W. Kleemann, I. Leipe, H. Urbach, A. Wagner.; citation_volume=1027; citation_publication_date=1990; citation_pages=25-30; citation_id=CR33 citation_journal_title=Pharm. Res.; citation_title=Renin inhibitor: transport mechanism in rat small intestinal brush-border membrane vesicles; citation_author=N. Hashimoto, T. Fujioka, T. Toyoda, N. Muranishi, K. Hirano. ; citation_volume=11; citation_publication_date=1994; citation_pages=1448-1451; citation_id=CR34 citation_journal_title=Biochem. Pharmacol.; citation_title=Bestatine trasnport in rabbit intestinal brush-border membrane vesicles; citation_author=M. Takano, Y. Tomita, T. Katsura, M. Yasuhara, K. Inui, R. Hori. ; citation_volume=47; citation_publication_date=1994; citation_pages=1089-1090; citation_id=CR35 citation_journal_title=Pharm. Res.; citation_title=Transepithelial properties of peptidomimetic thrombin inhibitors in monolayers of a human intestinal cell line (Caco-2) and their correlation to in vivo data; citation_author=E. Walter, T. Kissel, M. Reers, G. Dickneite, D. Hofmann, W. Stuber.; citation_volume=12; citation_publication_date=1995; citation_pages=360-365; citation_id=CR36 citation_journal_title=Pharm. Res.; citation_title=Mechanism of absorption of the dipeptide α-methyldopa-phe in the intestinal brush-border membrane vesicles; citation_author=A. Tsuji, I. Tamai, M. Nakanishi, G. L. Amidon; citation_volume=7; citation_publication_date=1990; citation_pages=308-309; citation_id=CR37 citation_journal_title=Pharm. Res.; citation_title=pGlu-L-dopa-pro: A tripeptide prodrug targeting the intestinal peptide transporter for absorption and tissue enzymes for conversion; citation_author=J. P. F. Bai.; citation_volume=12; citation_publication_date=1995; citation_pages=1101-1104; citation_id=CR38 citation_title=Role of active transport in regulation of junctional permeability and paracellular absorption of nutrients by intestinal epithelia; citation_inbook_title=Transport in leaky epithelial; citation_publication_date=1993; citation_id=CR39; citation_author=J. R. Pappenheimer; citation_author=J. M. Madara.; citation_publisher=Munksgaard citation_journal_title=Nature; citation_title=Expression cloning and cDNA sequencing of the Na+/glucose cotransporte; citation_author=M. A. Hediger, M. J. Coady, T. S. Ikeda, E. M. Wright. ; citation_volume=330; citation_publication_date=1987; citation_pages=379-381; citation_id=CR40 citation_journal_title=Physiol. Rev.; citation_title=Molecular physiology of sodium-glucose cotransporters; citation_author=M. A. Hediger, D. B. Rhoads.; citation_volume=74; citation_publication_date=1994; citation_pages=993-1026; citation_id=CR41 citation_journal_title=J. Biol. Chem.; citation_title=The high affinity Na+/glucose cotransporter. Re-evaluation of function and distribution of expression; citation_author=W.-S. Lee, Y. Kanai, R. G. Wells, M. A. Hediger.; citation_volume=269; citation_publication_date=1994; citation_pages=12032-12039; citation_id=CR42 citation_journal_title=J. Biol. Chem.; citation_title=Human facilitative glucose transporters; citation_author=T. Kayano, C. F. Burant, H. Fukumoto, G. W. Gould, Y-S. Fan, R. L. Eddy, M. G. Byers, T. B. Shoes, S. Seino, G. I. Bell. ; citation_volume=265; citation_publication_date=1990; citation_pages=13276-13282; citation_id=CR43 citation_journal_title=Am. J. Physiol.; citation_title=Sequence, tissue distribution, and functional characterization of the rat fructose transporter GLUT5; citation_author=E. B. Rand, A. M. Depaoli, N. O. Davidson, G. I. Bell, C. F. Burant. ; citation_volume=264; citation_publication_date=1993; citation_pages=G1169-1176; citation_id=CR44 citation_journal_title=Biochem. J.; citation_title=Characterizastion of the rabbit intestinal fructose transporter (GLUT5); citation_author=K. Miyamoto, S. Tatsumi, A. Morimoto, H. Minami, H. Yamamoto, K. Sone, Y. Taketani, Y. Nakabou, T. Oka, E. Takeda. ; citation_volume=303; citation_publication_date=1994; citation_pages=877-883; citation_id=CR45 citation_journal_title=Proc. Natl. Acad. Sci. USA; citation_title=Sequence, tissue distribution, and chromosomal localization of mRNA encoding a human glucose transporter-like protein; citation_author=H. Fukumoto, S. Seino, H. Imura, Y. Seino, R. L. Eddy, Y. Fukushima, M. G. Byers, T. B. Shows, G. I. Bell.; citation_volume=85; citation_publication_date=1988; citation_pages=5434-5438; citation_id=CR46 citation_journal_title=Biochemistry; citation_title=Expression of human glucose transporters in Xenopus Oocytes: kinetic characterization and substrate specificities of the erythrocyte, liver, and brain isoforms; citation_author=G. W. Gould, H. M. Thomas, T. J. Jess, G. I. Bell.; citation_volume=30; citation_publication_date=1991; citation_pages=5139-5145; citation_id=CR47 citation_journal_title=Am. J. Physiol.; citation_title=Liver glucose transporter: a basolateral protein in hepatocytes and intestine and kidney cells; citation_author=B. Thorens, Z-Q. Cheng, D. Brown, H. F. Lodish.; citation_volume=259; citation_publication_date=1990; citation_pages=C279-285; citation_id=CR48 citation_journal_title=Biochem. Pharmacol.; citation_title=Intestinal active absorption of sugar-conjugated compounds by glucose transport system: implication of improvement of poorly absorbable drugs; citation_author=T. Mizuma, K. Ohta, M. Hayashi, S. Awazu.; citation_volume=43; citation_publication_date=1992; citation_pages=2037-2039; citation_id=CR49 citation_journal_title=Biochim. Biophys. Acta; citation_title=The β-anomeric and glucose perferences of glucose transport carrier for intestinal active absorption of monosaccharide conjugates; citation_author=T. Mizuma, K. Ohta, S. Awazu.; citation_volume=1200; citation_publication_date=1994; citation_pages=117-122; citation_id=CR50 citation_journal_title=Biochem. Biophys. Res. Commun.; citation_title=Na+-Dependent transport of aminopeptidase-resistant sugar-coupled tripeptides in rat intestine; citation_author=T. Mizuma, N. Sakai, S. Awazu.; citation_volume=203; citation_publication_date=1994; citation_pages=1412-1416; citation_id=CR51 citation_journal_title=Chem. Pharm. Bull.; citation_title=Hypoglycemic effect of intestinally administered monosaccharide-modified insulin derivatives in rats; citation_author=M. Haga, K. Saito, T. Shimaya, Y. Maezawa, Y. Kato, S. W. Kim. ; citation_volume=38; citation_publication_date=1990; citation_pages=1983-1986; citation_id=CR52 citation_title=Transport of weak electrolytes; citation_inbook_title=Handbook of Physiology; citation_publication_date=1991; citation_pages=371-388; citation_id=CR53; citation_author=G. Rechkemmer.; citation_publisher=American Physiological Society citation_journal_title=Naunyn-Schmiedebergs Arch Pharmacol.; citation_title=Drug absorption by the rat jejunum perfused in situ. Dissociation from the pH-partition theory and role of microclimate-pH and unstirred layer; citation_author=M. L. Hougerle, D. Winne.; citation_volume=322; citation_publication_date=1983; citation_pages=249-255; citation_id=CR54 citation_journal_title=Biochem. J.; citation_title=A proton gradient, not a sodium gradient, is the driving force for active transport of lactate in rabbit intestinal brush-border membrane vesicles; citation_author=C. Tiruppathi, D. F. Balkovetz, V. Ganapathy, Y. Miyamoto, F. H. Leibach.; citation_volume=256; citation_publication_date=1988; citation_pages=219-223; citation_id=CR55 citation_journal_title=Comp. Biochem. Physiol.; citation_title=Occurrence, absorption and metabolism of short chain fatty acids in the digestive tract of mammals; citation_author=M. Bugaut.; citation_volume=86B; citation_publication_date=1987; citation_pages=439-472; citation_id=CR56 citation_journal_title=J. Pharm. Sci.; citation_title=pH-Dependent intestinal transport of monocarboxylic acids: carriermediated and H+-cotransport mechanism versus pH-partition hypothesis; citation_author=A. Tsuji, M. T. Simanjuntak, I. Tamai, T. Terasaki.; citation_volume=79; citation_publication_date=1990; citation_pages=1123-1124; citation_id=CR57 citation_journal_title=Japn. J. Physiol.; citation_title=Stimulation of bicarbonate secretion by luminal short-chain fatty acids in the rat and human colon in vivo ; citation_author=M. Dohgen, H. Hayashi, T. Yajima, T. Suzuki.; citation_volume=44; citation_publication_date=1994; citation_pages=519-531; citation_id=CR58 citation_journal_title=J. Exp. Biol.; citation_title=Transintestinal acetate transport in a herbivorous teleost: anion exchange at the basolateral membrane; citation_author=E. Titus, G. A. Aheam.; citation_volume=156; citation_publication_date=1991; citation_pages=41-61; citation_id=CR59 citation_journal_title=J. Pharmacobio-Dyn.; citation_title=Participation of monocarboxylic anion and bicarbonate exchange system for the transport of acetic acid and monocarboxylic acid drugs in the small intestinal brush-border membrane vesicles; citation_author=M. T. Simanjuntak, T. Terasaki, I. Tamai, A. Tsuji.; citation_volume=14; citation_publication_date=1991; citation_pages=501-508; citation_id=CR60 citation_journal_title=Am. J. Physiol.; citation_title=Transport of propionate by ileal brush-border membrane vesicles; citation_author=J. M. Harig, K. H. Soergel, J. A. Barry, K. Ramaswamy. ; citation_volume=260; citation_publication_date=1991; citation_pages=G776-782; citation_id=CR61 citation_journal_title=Biochem. J.; citation_title=N-Terminal protein sequence analysis of the rabbit erythrocyte lactate transporter suggests identity with the cloned mono-carboxylate transport protein MCT1; citation_author=R. C. Poole, A. P. Halestrap.; citation_volume=303; citation_publication_date=1994; citation_pages=755-759; citation_id=CR62 citation_journal_title=Cell; citation_title=Molecular characterization of a membrane transporter for lactate, pyruvate, and other monocarboxylates: implications for the cori cycle; citation_author=C-K. Garcia, J. L. Goldstein, R. K. Pathak, R. G. W. Anderson, M. S. Brown.; citation_volume=76; citation_publication_date=1994; citation_pages=865-873; citation_id=CR63 citation_journal_title=Biochem. Biophys. Res. Commun.; citation_title=Participation of a proton-cotransporter, MCT1 in the intestinal transport mechanism for monocarboxylic acids; citation_author=I. Tamai, H. Takanaga, H. Maeda, Y. Sai, T. Ogihara, H. Higashida, A. Tsuji.; citation_volume=214; citation_publication_date=1995; citation_pages=482-489; citation_id=CR64 citation_journal_title=Biochem. Biophys. Res. Commun.; citation_title=cDNA cloning and functional characterization of rat intestinal monocarboxylate transporter; citation_author=H. Takanaga, I. Tamai, S. Inaba, Y. Sai, H. Higashida, H. Yamamoto, A. Tsuji.; citation_volume=217; citation_publication_date=1995; citation_pages=370-377; citation_id=CR65 citation_journal_title=Pharm. Res.; citation_title= In vitro drug absorption models. I. Brush border membrane vesicles, isolated mucosal cells and everted intestinal rings: Characterization and salicylate accumulation; citation_author=I. Osiecka, P. A. Porter, R. T. Borchardt, J. A. Fix, C. R. Gardner. ; citation_volume=2; citation_publication_date=1985; citation_pages=284-293; citation_id=CR66 citation_journal_title=J. Pharm. Pharmacol.; citation_title=pH-Dependent and carrier-mediated transport of salicylic acid across Caco-2 cells; citation_author=H. Takanaga, I. Tamai, A. Tsuji.; citation_volume=46; citation_publication_date=1994; citation_pages=567-570; citation_id=CR67 citation_journal_title=Pharm. Res.; citation_title=Transcellular transport of benzoic acid across Caco-2 cells by a pH-dependent and carrier-mediated transport mechanism; citation_author=A. Tsuji, H. Takanaga, I. Tamai, T. Terasaki.; citation_volume=11; citation_publication_date=1994; citation_pages=30-37; citation_id=CR68 citation_journal_title=Pharm. Res.; citation_title=Proton-cotransport of pravastatin across intestinal brush-border membrane; citation_author=I. Tamai, H. Takanaga, H. Maeda, T. Ogihara, M. Yoneda, A. Tsuji.; citation_volume=12; citation_publication_date=1995; citation_pages=1727-1732; citation_id=CR69 citation_journal_title=Biochem. J.; citation_title=Phosphate transport into brush-border membrane vesicles isolated from rat small intestine; citation_author=W. Berner, R. Kinne, H. Murer.; citation_volume=160; citation_publication_date=1976; citation_pages=467-474; citation_id=CR70 citation_journal_title=Gastroenterology; citation_title=Phosphate transport in human jejunal brush-border membrane vesicles; citation_author=S. M. Borowitz, F. K. Ghishan.; citation_volume=96; citation_publication_date=1989; citation_pages=4-10; citation_id=CR71 citation_journal_title=Biochem. Pharmacol.; citation_title=Na+ and pH dependent transport of foscarnet via the phosphate carrier system across intestinal brush-border membrane; citation_author=A. Tsuji, I. Tamai.; citation_volume=38; citation_publication_date=1989; citation_pages=1019-1022; citation_id=CR72 citation_journal_title=J. Pharmacol. Exp. Ther.; citation_title=Carrier-mediated transport mechanism of foscarnet (trisodium phosphonoformate hexahydrate) in rat intestinal tissue; citation_author=P. W. Swaan, J. J. Tukker.; citation_volume=272; citation_publication_date=1994; citation_pages=242-247; citation_id=CR73 citation_journal_title=J. Pharmacobio-Dyn.; citation_title=Sodium and pH dependent carrier-mediated transport of antibiotic, fosfomycin, in the rat intestinal brush-border membrane; citation_author=T. Ishizawa, A. Tsuji, I. Tamai, T. Terasaki, K. Hosoi, S. Fukatsu. ; citation_volume=13; citation_publication_date=1990; citation_pages=292-300; citation_id=CR74 citation_journal_title=J. Pharmacobio-Dyn.; citation_title=Mechanisms of intestinal absorption of the antibiotic, fosfomycin, in brush-border membrane vesicles in rabbits and humans; citation_author=T. Ishizawa, S. Sadahiro, K. Hosoi, I. Tamai, T. Terasaki, A. Tsuji.; citation_volume=15; citation_publication_date=1992; citation_pages=481-489; citation_id=CR75 citation_journal_title=J. Pharmacobio-Dyn.; citation_title=Effect of carrier-mediated transport system on intestinal fosfomysin absorption in situ and in vivo ; citation_author=T. Ishizawa, M. Hayashi, S. Awazu.; citation_volume=14; citation_publication_date=1991; citation_pages=82-86; citation_id=CR76 citation_journal_title=Am. J. Physiol.; citation_title=Intestinal transport of bile acids; citation_author=F. A. Wilson.; citation_volume=241; citation_publication_date=1981; citation_pages=G83-G92; citation_id=CR77 citation_journal_title=J. Biol. Chem.; citation_title=Expression cloning and characterization of the hamster ileal sodium-dependent bile acid transporter; citation_author=M. H. Wong, P. Oelkers, A. L. Craddock, P. A. Dawson. ; citation_volume=269; citation_publication_date=1994; citation_pages=1340-1347; citation_id=CR78 citation_journal_title=J. Biol. Chem.; citation_title=Intestinal absorption of peptides by coupling to bile acids; citation_author=W. Kramer, G. Wess, G. Neckermann, G. Schubert, J. Fink, F. Girbig, U. Gutjahr, S. Kowalewski, K.-H. Baringhaus, G. Boger, A. Enhsen, E. Falk, M. Friedrich, H. Glombik, A. Hoffmann, C. Pittius, M. Urmann; citation_volume=269; citation_publication_date=1994; citation_pages=10621-10627; citation_id=CR79 citation_journal_title=J. Pharmacobio-Dyn.; citation_title=Carrier-mediated uptake of nicotinic acid by rat intestinal brush-border membrane vesicles and relation to monocarboxylic acid transport; citation_author=M. T. Simanjuntak, I. Tamai, T. Terasaki, A. Tsuji.; citation_volume=13; citation_publication_date=1990; citation_pages=301-309; citation_id=CR80 H. Takanaga, H. Maeda, I. Tamai, H. Higashida, and A. Tsuji. Nicotinic acid transport mediated by pH-dependent anion antiporter and proton cotransporter in rabbit intestinal brush-border membrane. J. Pharm. Pharmacol. in press. citation_title=Intestinal transport of water-soluble vitamins; citation_inbook_title=Handbook of Physiology; citation_publication_date=1991; citation_pages=421-435; citation_id=CR82; citation_author=R. C. Rose.; citation_publisher=American Physiological Society citation_journal_title=Am. J. Physiol.; citation_title=Folate transport by intestinal brush-border membrane vesicles; citation_author=H. M. Said, F. K. Ghishan, R. Redha.; citation_volume=252; citation_publication_date=1987; citation_pages=G229-G236; citation_id=CR83 citation_journal_title=Biochem. J.; citation_title=A carrier-mediated transport for folate in basolateral membrane vesicles of rat small intestine; citation_author=H. M. Said, R. Redha.; citation_volume=247; citation_publication_date=1987; citation_pages=141-146; citation_id=CR84 citation_journal_title=Biochem. Pharmacol.; citation_title=Methotrexate transport in the human intestine; citation_author=J. Zimmerman.; citation_volume=43; citation_publication_date=1992; citation_pages=2377-2383; citation_id=CR85 citation_journal_title=Proc. Natl. Acad. Sci. USA; citation_title=Folate receptor allows cells to grow in low concentrations of 5-methyltetrahydrofolate; citation_author=H. Matsue, K. G. Rothberg, A. Takashima, B. A. Kamen, R. G. W. Anderson, S. W. Lacey.; citation_volume=89; citation_publication_date=1992; citation_pages=6006-6009; citation_id=CR86 citation_journal_title=Biochim. Biophys. Acta; citation_title=Carrier-mediated transport system for choline and its related quaternary ammonium compounds on rat intestinal brush-border membrane; citation_author=H. Saitoh, M. Kobayashi, M. Sugawara, K. Iseki, K. Miyazaki. ; citation_volume=1112; citation_publication_date=1992; citation_pages=153-160; citation_id=CR87 citation_journal_title=Biochim. Biophys. Acta; citation_title=Intestinal absorption of choline in the chick; citation_author=G. R. Herzberg, J. Lerner.; citation_volume=307; citation_publication_date=1972; citation_pages=234-242; citation_id=CR88 citation_journal_title=Adv. Pharmacol.; citation_title=Structure and function of P-glycoprotein in normal liver and small intestine; citation_author=Z. C. Gatmaitan, I. M. Arias.; citation_volume=24; citation_publication_date=1993; citation_pages=77-97; citation_id=CR89 citation_journal_title=Anticancer Res.; citation_title=P-glycoprotein and pharmacokinetics; citation_author=D. Leveque, F. Jehl.; citation_volume=15; citation_publication_date=1995; citation_pages=331-336; citation_id=CR90 citation_journal_title=Cell; citation_title=Distruction of the mouse mdrla P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs; citation_author=A. H. Schinkel, J. J. M. Smit, O. van Tellingen, J. H. Beijnen, E. Wagnenaar, L. van Deemter, C. A. A. M. Mol, M. A. van der Valk, E. C. Robanus-Maandag, H. P. J. te Riele, A. J. M. Berns, P. Borst.; citation_volume=77; citation_publication_date=1994; citation_pages=491-502; citation_doi=10.1016/0092-8674(94)90212-7; citation_id=CR91 citation_journal_title=Life Sci.; citation_title=P-glycoprotein as drug efflux pump in primary cultured bovine brain capillary endothelial cells; citation_author=A. Tsuji, T. Terasaki, Y. Takabatake, Y. Tenda, I. Tamai, T. Yamashita, S. Moritani, T. Tsuruo, J. Yamashita.; citation_volume=51; citation_publication_date=1992; citation_pages=1427-1437; citation_id=CR92 citation_journal_title=Biochem. Pharmacol.; citation_title=Restricted transport of cyclosporin A across the blood-brain barrier by a multidrug transporter, p-glycoprotein; citation_author=A. Tsuji, I. Tamai, A. Sakata, Y. Tenda, T. Terasaki.; citation_volume=46; citation_publication_date=1993; citation_pages=1096-1099; citation_id=CR93 citation_journal_title=Biochem. Pharmacol.; citation_title= In vivo evidence for ATP-dependent and P-glycoprotein-mediated transport of cyclosporin A at the blood-brain barrie; citation_author=A. Sakata, I. Tamai, K. Kawazu, Y. Deguchi, T. Ohnishi, A. Saheki, A. Tsuji.; citation_volume=48; citation_publication_date=1994; citation_pages=1989-1992; citation_id=CR94 citation_journal_title=Biochem. Pharmacol.; citation_title= In vivo and in vitro evidence for ATP-dependency of P-glycoprotein-mediated efflux of doxorubicin at the blood-brain barrier; citation_author=T. Ohnishi, I. Tamai, K. Sakanaka, A. Sakata, T. Yamashima, J. Yamashita, A. Tsuji.; citation_volume=49; citation_publication_date=1995; citation_pages=1541-1544; citation_id=CR95 citation_journal_title=Br. J. Cancer; citation_title=Epithelial secretion of vinblastine by human intestinal adenocarcinoma cell (HCT-8 and T84) layers expressing P-glycoprotein; citation_author=J. Hunter, B. H. Hirst, N. L. Simmons.; citation_volume=64; citation_publication_date=1991; citation_pages=437-444; citation_id=CR96 citation_journal_title=Cancer Commun.; citation_title=P-Glycoprotein content and mediation of vincristine efflux: correlation with the level of differentiation in luminal epithelium of mouse small intestine; citation_author=M. B. Meyers, K. W. Scitto, F. M. Sirotnak.; citation_volume=3; citation_publication_date=1991; citation_pages=159-165; citation_id=CR97 citation_journal_title=Pharm. Res.; citation_title=Drug absoprtion limited by P-glycoprotein-mediated secretory drug transport in human intestinal epithelial Caco-2 cell layers; citation_author=J. Hunter, B. H. Hirst, N. L. Simmons.; citation_volume=10; citation_publication_date=1993; citation_pages=743-749; citation_id=CR98 citation_journal_title=Cancer Chemother. Pharmacol.; citation_title=Inhibition of P-glycoprotein and effects on etoposide absorption; citation_author=B.-L. Leu, J.-D. Huang.; citation_volume=35; citation_publication_date=1995; citation_pages=432-436; citation_id=CR99 citation_journal_title=Eur. J. Pharmacol.; citation_title=Interaction of pristinamycin IA with P-glycoprotein in human intestinal epithelial cells; citation_author=V. Phung-Ba, A. Warnery, D. Schermann, P. Wils.; citation_volume=288; citation_publication_date=1995; citation_pages=187-192; citation_id=CR100 citation_journal_title=Biochem. Biophys. Res. Commun.; citation_title=Evidence for a polarized efflux system in Caco-2 cells capable of modulating cyclosporn A transport; citation_author=P. A. Augustijns, T. Timothy, P. Badshaw, L.-S. L. Gan, R. W. Hendren, D. R. Thakker.; citation_volume=197; citation_publication_date=1993; citation_pages=360-365; citation_id=CR101 citation_journal_title=Biochem. Biophys. Res. Commun.; citation_title=Evidence for a polarized efflux system for peptides in the apical membrane of Caco-2 cells; citation_author=P. S. Burton, R. A. Conradi, A. R. Hilgers, N. H. Ho.; citation_volume=190; citation_publication_date=1993; citation_pages=760-766; citation_id=CR102 citation_journal_title=Br. J. Pharmacol.; citation_title=Transport of celiprolol across human epithelial (Caco-2) cells: mediation of secretion by multiple transporters including P-glycoprotein; citation_author=J. Karlsson, S.-M. Kuo, J. Ziemniak, P. Artursson.; citation_volume=110; citation_publication_date=1993; citation_pages=1009-1016; citation_id=CR103 citation_journal_title=Pharm. Res.; citation_title=Possible involvement of multiple P-glycoprotein-mediated efflux system in the transport of verapamil and other organic cations across rat intestine; citation_author=H. Saitoh, B. J. Aungst.; citation_volume=12; citation_publication_date=1995; citation_pages=1304-1310; citation_id=CR104 citation_journal_title=Gastroenterology; citation_title=The function of Gp170, the multidrug-resistance gene product, in the brush border of rat intestinal mucosa; citation_author=S. Hsing, Z. C. Gatmaitan, I. M. Arias.; citation_volume=102; citation_publication_date=1992; citation_pages=879-885; citation_id=CR105 citation_journal_title=J. Natl. Cancer Inst.; citation_title=Enhancement of cellular accumulation of cyclosporine by anti-P-glycoprotein monoclonal antibody MRK-16 and synergistic modulation of multidrug resistance; citation_author=M. Naito, H. Tsuge, C. Kuroko, T. Koyama, A. Tomida, T. Tatsuya, Y. Heike, T. Tsuruo.; citation_volume=85; citation_publication_date=1993; citation_pages=311-316; citation_id=CR106 citation_journal_title=Int. J. Pharm.; citation_title=Quantitative mechanistic studies in simultaneous fluid flow and intestinal absorption using steroids as model solutes; citation_author=I. Komiya, J. Y. Park, A. Kamani, N. F. H. Fo., W. I. Higuchi. ; citation_volume=4; citation_publication_date=1980; citation_pages=249-262; citation_id=CR107 citation_journal_title=J. Med. Chem.; citation_title=A practitioner's perspective of the role of quantitative structure-activity analysis in medicinal chemistry; citation_author=Y. C. Martin.; citation_volume=24; citation_publication_date=1981; citation_pages=229-237; citation_id=CR108 citation_journal_title=J. Pharm. Pharmacol.; citation_title=The absorption of β-adrenoreceptor antagonists in rat in-situ small intestine; The effect of lipophilicity; citation_author=D. C. Taylor, R. Pownall, W. Burke.; citation_volume=37; citation_publication_date=1985; citation_pages=280-283; citation_id=CR109 citation_journal_title=J. Biol. Chem.; citation_title=Deletion and insertion mutant of the multidrug transporter; citation_author=S. J. Cirrier, K. Ueda, M. C. Willingham, I. Pastan, M. Gottesman. ; citation_volume=264; citation_publication_date=1989; citation_pages=14376-14381; citation_id=CR110