Carnosic acid prevents obesity and hepatic steatosis in ob/ob mice

Hepatology Research - Tập 41 Số 1 - Trang 87-92 - 2011
Ting Wang1, Yasuhiro Takikawa2, Takumi Satoh3, Yoshichika Yoshioka4, Kunio Kosaka5, Yoshinori Tatemichi6, Kazuyuki Suzuki2
1Iwate Medical University, Morioka, Japan
2Dept. of Gastroenterology and Hepatology, Iwate Medical University.
3Department of Welfare Engineering, Faculty of Engineering, Iwate University
4Immunology Frontier Research Center, Osaka University, Osaka
5Research and Development Center, Nagase, Tokyo, Japan
6Department of Pathology, Iwate Medical University School of Medicine, Morioka

Tóm tắt

Aim:  Carnosic acid (CA) inhibits adipogenesis in vitro. The present study evaluated the therapeutic effects of CA in ob/ob mice.Methods:  The experimental animals were given a standard chow diet with or without CA for 5 weeks. Bodyweight gain and food intake were measured during this period. Magnetic resonance imaging analysis, histological examination, serum chemistry analysis and intraperitoneal glucose tolerance test (IPGTT) were all performed.Results:  The mice fed CA experienced significant weight loss and reduced visceral adiposity, in addition to significantly reduced serum triglyceride (TG) and cholesterol levels. Importantly, CA had a dramatic effect on the liver by reducing the hepatic TG content, thus decreasing serum alanine aminotransferase levels. In addition, IPGTT revealed that CA significantly improved glucose tolerance.Conclusion:  These data suggest that CA is a novel therapeutic agent for obesity‐related non‐alcoholic fatty liver disease.

Từ khóa


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Thông tin
Thông tin xuất bản

Hepatology Research

Tập 41 Số 1

87-92

Thông tin tác giả