Carfilzomib cải thiện đáng kể thời gian sống không tiến triển ở bệnh nhân có nguy cơ cao trong bệnh lý đa u tủy xương

Blood - Tập 128 - Trang 1174-1180 - 2016
Hervé Avet-Loiseau1,2, Rafael Fonseca3, David Siegel4, Meletios A. Dimopoulos5, Ivan Špička6, Tamás Masszi7, Roman Hájek8, Laura Rosiñol9, Vesselina Goranova-Marinova10, Georgi Mihaylov11, Vladimír Maisnar12, Maria-Victoria Mateos13, Michael Wang14, Ruben Niesvizky15, Albert Oriol16, Andrzej Jakubowiak17, Jiri Minarik18, Antonio Palumbo19, William Bensinger20, Vishal Kukreti21
1Centre de Recherche en Cancérologie de Toulouse INSERM U1037, Toulouse, France;
2L'Institut Universitaire du Cancer de Toulouse-Oncopole, Centre Hospitalier Universitaire, Toulouse, France
3Mayo Clinic, Scottsdale, AZ
4John Theurer Cancer Center at Hackensack University, Hackensack, NJ
5National and Kapodistrian University of Athens, Athens, Greece
6Department of Internal Medicine, University Hospital, Praha, Czech Republic
7St. István and St. Laszlo Hospital, Budapest, Hungary
8University Hospital Ostrava and Faculty of Medicine, University of Ostrava, Ostrava, Czech Republic
9Hospital Clínic de Barcelona, Barcelona, Spain
10Hematology Clinic University Multiprofile Hospital for Active Treatment “Sv. Georgi” and Medical University, Plovdiv, Bulgaria
11Queen Joanna University Hospital, Sofia, Bulgaria
12Charles University Faculty Hospital and Faculty of Medicine, Hradec Králové, Czech Republic
13University Hospital of Salamanca–Instituto de Investigación Biomédica de Salamanca, Salamanca, Spain
14The University of Texas MD Anderson Cancer Center, Houston, TX
15Weill Cornell Medical College/New York Presbyterian Hospital, New York, NY
16Institut Català d'Oncologia, Institut Josep Carreras, Hospital Germans Trias i Pujol, Barcelona, Spain
17University of Chicago Medical Center, Chicago, IL;
18Department of Hemato-Oncology, University Hospital Olomouc, Olomouc, Czech Republic
19University of Torino, Torino, Italy
20Fred Hutchinson Cancer Research Center, Seattle, WA
21Princess Margaret Cancer Centre, Toronto, ON, Canada

Tóm tắt

Điểm chính KRd có hồ sơ lợi ích-rủi ro thuận lợi hơn so với Rd, không phụ thuộc vào tình trạng rủi ro sinh học cơ bản, ở bệnh nhân mắc MM tái phát. KRd cải thiện nhưng không loại bỏ dự đoán xấu liên quan đến sinh học nguy cơ cao ở những bệnh nhân mắc MM tái phát.

Từ khóa


Tài liệu tham khảo

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