Carbohydrate Epitopes and Their Relevance for the Diagnosis and Treatment of Allergic Diseases

International Archives of Allergy and Immunology - Tập 129 Số 3 - Trang 189-197 - 2002
Ronald van Ree1
1Department of Immunopathology, Sanquin Research, Amsterdam, the Netherlands

Tóm tắt

Allergenicity of plant and invertebrate N-glycans has been shown to be caused by the presence of two typical nonmammalian substitutions: an α(1,3)-fucose linked to the proximal N-acetylglucosamine and a β(1,2)-xylose linked to the core mannose. IgE antibodies against these carbohydrate structures are induced upon exposure to pollen or after insect stings, and result in extensive cross-reactivity to plant and invertebrate foods. These cross-reactive IgE antibodies have been shown to possess variable degrees of biological activity, but have never been convincingly shown to induce clinical food allergy. The most likely explanation for this lack of clinical relevance has to be sought in a combination of epitope valency and antibody affinity. In diagnostic tests, these antibodies are at the basis of many false-positive test results for food allergy. Recombinant technologies offer the possibility to produce allergens that do not carry IgE-binding glycans. Whether their absence or presence is of importance for the application of recombinant allergens in immunotherapy is still largely unknown.

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10.1046/j.1365-2222.1999.00592.x

10.1159/000024217

10.1159/000024404

10.1067/mai.2000.107602

10.1034/j.1398-9995.2002.23686.x

10.1034/j.1398-9995.2002.13423.x

10.1067/mai.2001.116430

10.1023/A:1006012005654

10.1046/j.1365-313X.1994.05020157.x

10.1074/jbc.272.27.16884

10.1073/pnas.96.26.14736

10.1016/S0031-9422(01)00029-2

10.1023/A:1011010206774

10.1016/0161-5890(83)90050-0

10.1006/abio.1993.1088

10.1016/S0031-9422(00)89507-2

10.1074/jbc.275.15.11451

10.1074/jbc.271.43.26653

10.1023/A:1006947701714

10.1038/nbt1096-1269

10.1159/000024355

10.1067/mai.2002.126380

10.1034/j.1398-9995.2002.23553.x

10.1159/000024058

10.1159/000057742

10.1046/j.1432-1033.2002.02990.x

10.1046/j.1365-2222.2002.01312.x

10.1159/000049525

10.1074/jbc.273.43.28091

10.1159/000024112

10.1159/000049514

10.1271/bbb.65.563

10.1046/j.1365-2222.2002.01437.x

10.1046/j.1432-1033.2002.02990.x

10.1046/j.1432-1033.2002.02920.x

10.1159/000023907

10.1159/000053665

10.1034/j.1398-9995.2000.00120.x

10.1159/000053704

10.1126/science.296.5567.490

10.1146/annurev.immunol.20.083001.084359

10.1084/jem.20020073

10.1016/S1471-4906(02)02233-0

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International Archives of Allergy and Immunology

Tập 129 Số 3

189-197

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