Capillary Permeability to and Extravascular Dynamics of Myoglobin, Albumin and Gammaglobulin in the Uvea

Wiley - Tập 73 Số 1-2 - Trang 204-219 - 1968
Anders Bill1
1Department of Experimental Ophthalmology, the Wallenberg Laboratory, Institute of Pharmacology, University of Uppsala, Sweden

Tóm tắt

AbstractThe dynamics of myoglobin, albumin and gammaglobulin in the tissue fluids of the rabbit eye were studied in two‐isotope experiments to elucidate the mechanisms for transcapillary movement of protein and protein drainage from the eye, the nature of the blood‐aqueous barrier and the way in which extravascular protein may influence the formation of aqueous humor.The permeability of the blood vessels of the choroid and the ciliary processes to myoglobin was 10 to 15 times higher than that to albumin which was about twice that to gammaglobulin.In the tissue fluid of the ciliary processes the turnover rate constant for myoglobin was 25 per cent/min, for albumin it was 3.9 per cent/min and for gammaglobulin 1.6 per cent/min.The extravascular albumin spaces in the ciliary processes and the choroid were 158 μl/g and 165 μ/g respectively.The extravascular albumin spaces were 68 and 57 per cent of the myoglobin spaces in the ciliary processes and the choroid, respectively.The extravascular gammaglobulin spaces were 87, 98 and 117 per cent of the extravascular albumin spaces in the choroid, the ciliary processes and the rest of the anterior uvea, respectively.The methods employed will give new information about the dynamics of the tissue fluids also in tissues with lymph vessels.

Từ khóa


Tài liệu tham khảo

10.1007/BF00406306

10.1111/j.1748-1716.1964.tb02865.x

10.1016/S0014-4835(64)80033-6

Bill A., 1967, Further studies on the influence of the intraocular pressure on aqueous humour dynamics in cynomolgus monkeys, Invest.Ophthal., 6, 364

Bill A. A method to determine osmotically effective albumin and gammaglobulin concentrations in tissues fluids its fluids its application to the uvea and a note on the effect of capillary “leaks” on tissue fluid dynamics.To be publ.

Bill A., 1965, Production and drainage of aqueous humour in the cynomolgus monkey (Macaca irus), Invest.Ophthal., 4, 920

10.1007/BF00184135

10.1085/jgp.48.1.1

10.1210/endo-74-2-255

Dyster‐Aas K., 1964, Aqueous flow determination in rabbits by means of a minimal eye trauma, Invest.Ophthal., 3, 127

Grotte G., 1956, Passage of dextran molecules across the blood‐lymph barrier, Acta chir.scand.

Kinsey V.E., 1964, The rabbit in eye research

Landis E.M., 1963, Exchange of substances through the capillary walls, In Handbook of Physiology, 961

Majno G., 1965, Ultrastructure of the vascular membrane, Handbook of Physiology, 2293

10.1016/S0022-5320(66)80108-9

10.1001/archopht.1960.00950020709014

Wegner K., 1967, Regional differences in the ultrastructure of the rabbit ciliary processes.The effect of anesthetics and fixation procedures, Invest.Ophthal., 6, 177

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Wiley

Tập 73 Số 1-2

204-219

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