Calmodulin Plays a Pivotal Role in Cellular Regulation

American Association for the Advancement of Science (AAAS) - Tập 207 Số 4426 - Trang 19-27 - 1980
Wai Yiu Cheung1
1Department of Biochemistry, St. Jude Children's Research Hospital, and professor of biochemistry, University of Tennessee Center for the Health Sciences, Memphis, 38101

Tóm tắt

The role of calcium ions (Ca 2+ ) in cell functions is beginning to be unraveled at the molecular level as a result of recent research on calcium-binding proteins and particularly on calmodulin. These proteins interact reversibly with Ca 2+ to form a protein ⋅ Ca 2+ complex, whose activity is regulated by the cellular flux of Ca 2+ . Many of the effects of Ca 2+ appear to be exerted through calmodulin-regulated enzymes.

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Tài liệu tham khảo

AMPHLETT, G.W., EFFECT OF TROPONIN C-LIKE PROTEIN FROM BOVINE BRAIN (BRAIN MODULATOR PROTEIN) ON MG-2+-STIMULATED ATPASE OF SKELETAL-MUSCLE ACTOMYOSIN, FEBS LETTERS 72: 163 (1976).

ANDERSEN, B, SPECIFIC VISUALIZATION OF DISTRIBUTION OF CALCIUM DEPENDENT REGULATORY PROTEIN OF CYCLIC NUCLEOTIDE PHOSPHODIESTERASE (MODULATOR PROTEIN) IN TISSUE-CULTURE CELLS BY IMMUNOFLUORESCENCE MICROSCOPY - MITOSIS AND INTER-CELLULAR BRIDGE, CYTOBIOLOGIE 17: 354 (1978).

ANDERSON, J.M., CALCIUM-DEPENDENT REGULATOR OF NAD KINASE IN HIGHER-PLANTS, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 84: 595 (1978).

ANDERSON, J.M., ISOLATION OF CALCIUM DEPENDENT MODULATOR PROTEIN FROM HIGHER-PLANTS AND FUNGI, FEDERATION PROCEEDINGS 38: 478 (1979).

APPLEMAN, M.M., ADVANCES IN CYCLIC NUCLEOTIDE RESEARCH 3: 65 (1973).

BERGSTROM, S, ENZYMATIC CONVERSION OF ESSENTIAL FATTY ACIDS INTO PROSTAGLANDINS - PROSTAGLANDINS + RELATED FACTORS 34, JOURNAL OF BIOLOGICAL CHEMISTRY 239: 4006 (1964).

BERRIDGE, M.J., ADVANCES IN CYCLIC NUCLEOTIDE RESEARCH 6: 1 (1975).

BROSTROM, C.O., CALCIUM-DEPENDENT ADENYLATE-CYCLASE FROM RAT CEREBRAL-CORTEX - REVERSIBLE ACTIVATION BY SODIUM-FLUORIDE, JOURNAL OF BIOLOGICAL CHEMISTRY 252: 5677 (1977).

BROSTROM, C.O., IDENTIFICATION OF A CALCIUM-BINDING PROTEIN AS A CALCIUM-DEPENDENT REGULATOR OF BRAIN ADENYLATE CYCLASE, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 72: 64 (1975).

BROSTROM, M.A., ADV ENZYME REGUL 8: 191 (1970).

BROSTROM, M.A., CALCIUM-DEPENDENT ADENYLATE-CYCLASE FROM RAT CEREBRAL-CORTEX - ACTIVATION BY GUANINE NUCLEOTIDES, ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 191: 341 (1978).

BROSTROM, M.A., REGULATION OF ADENYLATE-CYCLASE FROM GLIAL TUMOR-CELLS BY CALCIUM AND A CALCIUM-BINDING PROTEIN, JOURNAL OF BIOLOGICAL CHEMISTRY 251: 4744 (1976).

BUTCHER, R.W., ADENOSINE 3',5'-PHOSPHATE IN BIOLOGICAL MATERIALS .1. PURIFICATION AND PROPERTIES OF CYCLIC 3',5'-NUCLEOTIDE PHOSPHODIESTERASE AND USE SF THIS ENZYME TO CHARACTERIZE ADENOSINE 3',5'-PHOSPHATE IN HUMAN URINE, JOURNAL OF BIOLOGICAL CHEMISTRY 237: 1244 (1962).

CARAFOLI E CALCIUM TRANSPORT CO (1975).

CHEUNG, W.Y., ADVANCES IN CYCLIC NUCLEOTIDE RESEARCH 9: 233 (1978).

CHEUNG, W.Y., CYCLIC 3',5'-NUCLEOTIDE PHOSPHODIESTERASE PREPARATION OF A PARTIALLY INACTIVE ENZYME AND ITS SUBSEQUENT STIMULATION BY SNAKE VENOM, BIOCHIMICA ET BIOPHYSICA ACTA 191: 303 (1969).

CHEUNG, W.Y., CYCLIC 3',5'-NUCLEOTIDE PHOSPHODIESTERASE - PRONOUNCED STIMULATION BY SNAKE VENOM, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 29: 478 (1967).

CHEUNG, W.Y., CYCLIC 3,5-NUCLEOTIDE PHOSPHODIESTERASE . DEMONSTRATION OF AN ACTIVATOR, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 38: 533 (1970).

CHEUNG, W.Y., PROTEIN ACTIVATOR OF CYCLIC 3'-5'-NUCLEOTIDE PHOSPHODIESTERASE OF BOVINE OR RAT-BRAIN ALSO ACTIVATES ITS ADENYLATE CYCLASE, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 66: 1055 (1975).

CHEUNG, W.Y., CYCLIC 3',5'-NUCLEOTIDE PHOSPHODIESTERASE - EFFECT OF DIVALENT CATIONS, BIOCHIMICA ET BIOPHYSICA ACTA 242: 395 (1971).

Cheung W. Y. Calcium-Binding Proteins and Calcium Function 1:.

CHEUNG, W.Y., CYCLIC NUCLEOTIDES D: 321 (1975).

CHEUNG, W.Y., CYCLIC 3',5'-NUCLEOTIDE PHOSPHODIESTERASE - EVIDENCE FOR AND PROPERTIES OF A PROTEIN ACTIVATOR, JOURNAL OF BIOLOGICAL CHEMISTRY 246: 2859 (1971).

CHEUNG, W.Y., ROLE CYCLIC AMP CELL: 51 (1970).

COHEN, P, CURRENT TOPICS IN CELLULAR REGULATION 14: 117 (1978).

COHEN, P, IDENTIFICATION OF CA2+-DEPENDENT MODULATOR PROTEIN AS 4TH SUBUNIT OF RABBIT SKELETAL-MUSCLE PHOSPHORYLASE KINASE, FEBS LETTERS 92: 287 (1978).

COLLINS J.H. CALCIUM BIOL SYSTEMS (1976).

COLLINS, J.H., AMINO-ACID SEQUENCE OF RABBIT SKELETAL-MUSCLE TROPONIN-C - GENE REPLICATION AND HOMOLOGY WITH CALCIUM-BINDING PROTEINS FROM CARP AND HAKE MUSCLE, FEBS LETTERS 36: 268 (1973).

DABROWSKA, R, CA-2+-DEPENDENT AND MODULATOR-DEPENDENT MYOSIN LIGHT CHAIN KINASE FROM NON-MUSCLE CELLS, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 85: 1352 (1978).

DABROWSKA, R, MODULATOR PROTEIN AS A COMPONENT OF MYOSIN LIGHT CHAIN KINASE FROM CHICKEN GIZZARD, BIOCHEMISTRY 17: 253 (1978).

DEDMAN, J.R., PHYSICOCHEMICAL PROPERTIES OF RAT TESTIS CA2+-DEPENDENT REGULATOR PROTEIN OF CYCLIC NUCLEOTIDE PHOSPHODIESTERASE - RELATIONSHIP OF CA2+-BINDING, CONFORMATIONAL-CHANGES, AND PHOSPHODIESTERASE ACTIVITY, JOURNAL OF BIOLOGICAL CHEMISTRY 252: 8415 (1977).

DEDMAN, J.R., SEQUENCE HOMOLOGY OF CA-2+- DEPENDENT REGULATOR OF CYCLIC NUCLEOTIDE PHOSPHODIESTERASE FROM RAT TESTIS WITH OTHER CA-2+- BINDING-PROTEINS, JOURNAL OF BIOLOGICAL CHEMISTRY 253: 343 (1978).

DELORENZO, R.J., STIMULATION OF CA2+-DEPENDENT NEUROTRANSMITTER RELEASE AND PRESYNAPTIC NERVE-TERMINAL PROTEIN-PHOSPHORYLATION BY CALMODULIN AND A CALMODULIN-LIKE PROTEIN ISOLATED FROM SYNAPTIC VESICLES, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 76: 1838 (1979).

DEMAILLE, J, TROPONINS C FROM REPTILE AND FISH MUSCLES AND THEIR RELATION TO MUSCULAR PARVALBUMINS, FEBS LETTERS 42: 173 (1974).

DICKERSON, R.E., J MOL EVOL 1: 26 (1971).

DRUMMOND, G.I., ENZYMATIC HYDROLYSIS OF ADENOSINE 3', 5'-PHOSPHORIC ACID, JOURNAL OF BIOLOGICAL CHEMISTRY 236: 1126 (1961).

DUNCAN C.J. CALCIUM BIOL SYSTEMS (1976).

EBASHI, S, ESSAYS IN BIOCHEMISTRY 10: 1 (1974).

EBASHI, S, THIRD COMPONENT PARTICIPATING IN SUPERPRECIPITATION OF NATURAL ACTOMYOSIN, NATURE 200: 1010 (1963).

EBASHI, S, QUART REV BIOPHYS 2: 351 (1969).

EPEL, D, PRIMARY METABOLIC CHANGE OF FERTILIZATION - INTERCONVERSION OF PYRIDINE NUCLEOTIDES, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 17: 62 (1964).

EPEL D UNPUBLISHED.

ERLICHMAN, J, INTERCONVERSION OF CYCLIC NUCLEOTIDE-ACTIVATED AND CYCLIC NUCLEOTIDE-INDEPENDENT FORMS OF A PROTEIN KINASE FROM BEEF HEART, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 68: 731 (1971).

FREI, E, PHOSPHOLIPASE A2 FROM SHEEP ERYTHROCYTE-MEMBRANES CA2+ DEPENDENCE AND LOCALIZATION, BIOCHIMICA ET BIOPHYSICA ACTA 550: 450 (1979).

Fullmer, C. S., Calcium-Binding Proteins and Calcium Function: 303 (1977).

GARCIA, A, LUNG SURFACTANT SYNTHESIS - CA++-DEPENDENT MICROSOMAL PHOSPHOLIPASE A2 IN LUNG, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 64: 128 (1975).

GILL, G.N., A CYCLIC-3',5'-ADENOSINE MONOPHOSPHATE DEPENDENT PROTEIN KINASE FROM ADRENAL CORTEX - COMPARISON WITH A CYCLIC AMP BINDING PROTEIN, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 39: 335 (1970).

GOLDBERG, N.D., CYCLIC-GMP METABOLISM AND INVOLVEMENT IN BIOLOGICAL REGULATION, ANNUAL REVIEW OF BIOCHEMISTRY 46: 823 (1977).

GOMEZ, S.L., CALCIUM-DEPENDENT PROTEIN ACTIVATOR OF MAMMALIAN CYCLIC NUCLEOTIDE PHOSPHODIESTERASE FROM BLASTOCLADIELLA-EMERSONII, FEBS LETTERS 99: 39 (1979).

GOPINATH, R.M., PHOSPHODIESTERASE PROTEIN ACTIVATOR MIMICS RED BLOOD-CELL CYTOPLASMIC ACTIVATOR OF (CA2+-MG2+)ATPASE, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 77: 1203 (1977).

GOREN, E.N., EFFECT OF NEUCLOTIDES AND NONDIALYZABLE FACTOR ON HYDROLYSIS OF CYCLIC AMP BY CYCLIC NUCLEOTIDE PHOSPHODIESTERASE FROM BEEF HEART, ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 142: 720 (1971).

GRAB, D.J., PRESENCE OF CALMODULIN IN POSTSYNAPTIC DENSITIES ISOLATED FROM CANINE CEREBRAL-CORTEX, JOURNAL OF BIOLOGICAL CHEMISTRY 254: 8690 (1979).

GRAND, RJA, TROPONIN C-LIKE PROTEINS (CALMODULINS) FROM MAMMALIAN SMOOTH-MUSCLE AND OTHER TISSUES, BIOCHEMICAL JOURNAL 177: 521 (1979).

GRAND, RJA, AMINO-ACID SEQUENCE OF TROPONIN C-LIKE PROTEIN (MODULATOR PROTEIN) FROM BOVINE UTERUS, FEBS LETTERS 92: 137 (1978).

GREASER, M.L., RECONSTITUTION OF TROPONIN ACTIVITY FROM 3 PROTEIN COMPONENTS, JOURNAL OF BIOLOGICAL CHEMISTRY 246: 4226 (1971).

GREENGARD P CYCLIC NUCLEOTIDES P (1978).

10.1126/science.22932

HANAHAN, D.J., INTERACTION OF CA2+-MG2+ ATPASE ACTIVATOR PROTEIN AND CA2+ WITH HUMAN ERYTHROCYTE-MEMBRANES, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 84: 1009 (1978).

Harper, J. F., Proceedings of the National Academy of Sciences of the United States of America 77: 366 (1980).

HATHAWAY, D.R., HUMAN-PLATELET MYOSIN LIGHT CHAIN KINASE REQUIRES THE CALCIUM-BINDING PROTEIN CALMODULIN FOR ACTIVITY, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 76: 1653 (1979).

HEAD, J.F., CALCIUM-BINDING MODULATOR PROTEIN FROM THE UNFERTILIZED EGG OF THE SEA-URCHIN ARBACIA-PUNCTULATA, JOURNAL OF CELL BIOLOGY 80: 211 (1979).

HEILBRUNN, L.V., THE ACTION OF VARIOUS CATIONS ON MUSCLE PROTOPLASM, JOURNAL OF CELLULAR AND COMPARATIVE PHYSIOLOGY 29: 15 (1947).

HINDS, T.R., PLASMA-MEMBRANE CA2+ TRANSPORT - STIMULATION BY SOLUBLE-PROTEINS, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 81: 455 (1978).

JAIMIESON, G.A., FED P FED AM SOC EXP 38: 478 (1979).

Jarrett, H. W., Journal of Biological Chemistry 253: 4676 (1978).

JARRETT, H.W., J BIOL CHEM 253: 4678 (1978).

JONES, H.P., HIGH LEVELS OF A CALCIUM-DEPENDENT MODULATOR PROTEIN IN SPERMATOZOA AND ITS SIMILARITY TO BRAIN MODULATOR PROTEIN, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 82: 1264 (1978).

JONES, H.P., ISOLATION AND CHARACTERIZATION OF CA-2+-DEPENDENT MODULATOR PROTEIN FROM THE MARINE INVERTEBRATE RENILLA-RENIFORMIS, BIOCHEMISTRY 18: 55 (1979).

KAKIUCHI, S, REGULATION OF BRAIN PHOSPHODIESTERASE ACTIVITY - CA++ PLUS MG++-DEPENDENT PHOSPHODIESTERASE AND ITS ACTIVATING FACTOR FROM RAT-BRAIN, ADVANCES IN CYCLIC NUCLEOTIDE RESEARCH 1: 455 (1972).

KAKIUCHI, S, CALCIUM DEPENDENT PHOSPHODIESTERASE ACTIVITY AND ITS ACTIVATING FACTOR (PAF) FROM BRAIN - STUDIES ON CYCLIC 3', 5'-NUCLEOTIDE PHOSPHODIESTERASE (III), BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 41: 1104 (1970).

KAKIUCHI, S, STIMULATION OF ACTIVITY OF CYCLIC 3',5'-NUCLEOTIDE PHOSPHODIESTERASE BY CALCIUM ION, PROCEEDINGS OF THE JAPAN ACADEMY 46: 387 (1970).

KAKIUCHI, S, REGULATION OF NUCLEOSIDE CYCLIC 3'-5'-MONOPHOSPHATE PHOSPHODIESTERASE ACTIVITY FROM RAT-BRAIN BY A MODULATOR AND CA2+, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 70: 3526 (1973).

KASERGLANZMANN, R, STIMULATION OF CALCIUM-UPTAKE IN PLATELET MEMBRANE-VESICLES BY ADENOSINE 3',5'-CYCLIC-MONOPHOSPHATE AND PROTEIN-KINASE, BIOCHIMICA ET BIOPHYSICA ACTA 466: 429 (1977).

KATZ, S, PHOSPHODIESTERASE PROTEIN ACTIVATOR STIMULATES CALCIUM-TRANSPORT IN CARDIAC MICROSOMAL PREPARATIONS ENRICHED IN SARCOPLASMIC-RETICULUM, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 83: 1373 (1978).

KLEE, C.B., CONFORMATIONAL TRANSITION ACCOMPANYING BINDING OF CA-2+ TO PROTEIN ACTIVATOR OF 3',5'-CYCLIC ADENOSINE-MONOPHOSPHATE PHOSPHODIESTERASE, BIOCHEMISTRY 16: 1017 (1977).

10.1021/bi00594a017

KORNBERG, R.D., STRUCTURE OF CHROMATIN, ANNUAL REVIEW OF BIOCHEMISTRY 46: 931 (1977).

KREBS, E.G., PHOSPHORYLATION-DEPHOSPHORYLATION OF ENZYMES, ANNUAL REVIEW OF BIOCHEMISTRY 48: 923 (1979).

KRETSINGER, R.H., CALCIUM-BINDING PROTEINS, ANNUAL REVIEW OF BIOCHEMISTRY 45: 239 (1976).

KRETSINGER, R.H., PREDICTED STRUCTURE OF CALCIUM-BINDING COMPONENT OF TROPONIN, BIOCHIMICA ET BIOPHYSICA ACTA 405: 40 (1975).

Kretsinger, R. H., Calcium-Binding Proteins and Calcium Function: 63 (1977).

Kretsinger, R. H., Critical Reviews in Biochemistry 8: 119 (1980).

KRETSINGER, R.H., CARP MUSCLE CALCIUM-BINDING PROTEIN .2. STRUCTURE DETERMINATION AND GENERAL DESCRIPTION, JOURNAL OF BIOLOGICAL CHEMISTRY 248: 3313 (1973).

KUMON, A, MODE OF ACTION OF ADENOSINE 3',5'-CYCLIC PHOSPHATE ON PROTEIN KINASE FROM RAT LIVER, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 41: 1290 (1970).

KUO, J.F., CYCLIC NUCLEOTIDE-DEPENDENT PROTEIN KINASES .4. WIDESPREAD OCCURRENCE OF ADENOSINE 3',5'-MONOPHOSPHATE-DEPENDENT PROTEIN KINASE IN VARIOUS TISSUES AND PHYLA OF ANIMAL KINGDOM, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 64: 1349 (1969).

LAPORTE, D.C., DETECTION OF CALCIUM-DEPENDENT REGULATORY PROTEIN-BINDING COMPONENTS USING I-125-LABELED CALCIUM-DEPENDENT REGULATORY PROTEIN, JOURNAL OF BIOLOGICAL CHEMISTRY 253: 3374 (1978).

LARNER, J, CURRENT TOPICS CELLU 3: 196 (1971).

10.1126/science.155309

LEDONNE, N. C., FEDERATION PROCEEDINGS 38: 317 (1979).

LEHKY, P, ISOLATION AND CHARACTERIZATION OF PARVALBUMINS FROM SKELETAL-MUSCLE OF HIGHER VERTEBRATES, JOURNAL OF BIOLOGICAL CHEMISTRY 249: 4332 (1974).

LEVIN, R.M., MECHANISM BY WHICH PSYCHOTROPIC-DRUGS INHIBIT ADENOSINE CYCLIC 3',5'-MONOPHOSPHATE PHOSPHODIESTERASE OF BRAIN, MOLECULAR PHARMACOLOGY 12: 581 (1976).

LEVIN, R.M., BINDING OF TRIFLUOPERAZINE TO CALCIUM-DEPENDENT ACTIVATOR OF CYCLIC NUCLEOTIDE PHOSPHODIESTERASE, MOLECULAR PHARMACOLOGY 13: 690 (1977).

LIU, Y.M., CYCLIC 3',5'-NUCLEOTIDE PHOSPHODIESTERASE CA++-DEPENDENT FORMATION OF BOVINE BRAIN ENZYME-ACTIVATOR COMPLEX, FEBS LETTERS 49: 356 (1975).

LIN, Y.M., CYCLIC 3'-5'-NUCLEOTIDE PHOSPHODIESTERASE - PURIFICATION, CHARACTERIZATION, AND ACTIVE FORM OF PROTEIN ACTIVATOR FROM BOVINE BRAIN, JOURNAL OF BIOLOGICAL CHEMISTRY 249: 4943 (1974).

LIN, Y.M., METHODS ENZYMOL C 39: 262 (1974).

LIU, Y.P., CYCLIC 3'=5'-NUCLEOTIDE PHOSPHODIESTERASE - CA2+ CONFERS MORE HELICAL CONFORMATION TO PROTEIN ACTIVATOR, JOURNAL OF BIOLOGICAL CHEMISTRY 251: 4193 (1976).

LYNCH, T.J., HUMAN-ERYTHROCYTE CA2+-MG2+-ATPASE - MECHANISM OF STIMULATION BY CA2+, ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 194: 165 (1979).

LYNCH, T.J., RAT-BRAIN ADENYLATE-CYCLASE - FURTHER-STUDIES ON ITS STIMULATION BY A CA2+-BINDING PROTEIN, ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 182: 124 (1977).

LYNCH, T.J., CA++-DEPENDENT FORMATION OF BRAIN ADENYLATE CYCLASE-PROTEIN ACTIVATOR COMPLEX, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 68: 616 (1976).

MARCUM, J.M., CONTROL OF MICROTUBULE ASSEMBLY-DISASSEMBLY BY CALCIUM-DEPENDENT REGULATOR PROTEIN, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 75: 3771 (1978).

MARCUS, A.J., LIPID COMPOSITION OF SUBCELLULAR PARTICLES OF HUMAN BLOOD PLATELETS, JOURNAL OF LIPID RESEARCH 10: 108 (1969).

MEINKES, M, JOURNAL OF CLINICAL INVESTIGATION 59: 449 (1977).

METZLER, D.E., BIOCH CHEM REACTIONS: 640 (1977).

MOORE, B.W., A SOLUBLE PROTEIN CHARACTERISTIC OF NERVOUS SYSTEM, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 19: 739 (1965).

NAGAO, S, ACTIVATION BY A CALCIUM-BINDING PROTEIN OF GUANYLATE-CYCLASE IN TETRAHYMENA-PYRIFORMIS, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 90: 261 (1979).

NAIR, K.G., PURIFICATION AND PROPERTIES OF 3',5'-CYCLIC NUCLEOTIDE PHOSPHODIESTERASE FROM DOG HEART, BIOCHEMISTRY 5: 150 (1966).

NAIRN, A.C., CALMODULIN AND MYOSIN LIGHT-CHAIN KINASE OF RABBIT FAST SKELETAL-MUSCLE, BIOCHEMICAL JOURNAL 179: 89 (1979).

Nelsestuen, G. L., Calcium-Binding Proteins and Calcium Function: 323 (1977).

NIMMO, H.G., ADVANCES IN CYCLIC NUCLEOTIDE RESEARCH 8: 145 (1977).

OSTWALD, T.J., ISOLATION OF A HIGH AFFINITY CALCIUM-BINDING PROTEIN FROM SARCOPLASMIC-RETICULUM, JOURNAL OF BIOLOGICAL CHEMISTRY 249: 974 (1974).

OSTWALD, T.J., EFFECTS OF CATION BINDING ON CONFORMATION OF CALSEQUESTRIN AND HIGH AFFINITY CALCIUM-BINDING PROTEIN OF SARCOPLASMIC-RETICULUM, JOURNAL OF BIOLOGICAL CHEMISTRY 249: 5867 (1974).

PENNISTON, J.T., CALMODULIN AND CA2+ ATPASE FROM BRAIN MICROSOMES, FEDERATION PROCEEDINGS 38: 478 (1979).

PERRY S.V. CONTRACTILE SYSTEMS (1976).

PICKETT, W. C., BIOCHIMICA ET BIOPHYSICA ACTA 486: 209 (1977).

Prendergast, F. G., Calcium-Binding Proteins and Calcium Function: 469 (1977).

RALL, T.W., THE RELATIONSHIP OF EPINEPHRINE AND GLUCAGON TO LIVER PHOSPHORYLASE .4. EFFECT OF EPINEPHRINE AND GLUCAGON ON THE REACTIVATION OF PHOSPHORYLASE IN LIVER HOMOGENATES, JOURNAL OF BIOLOGICAL CHEMISTRY 224: 463 (1957).

RALL, T.W., FORMATION OF A CYCLIC ADENINE RIBONUCLEOTIDE BY TISSUE PARTICLES, JOURNAL OF BIOLOGICAL CHEMISTRY 232: 1065 (1958).

RASMUSSEN, H, RELATIONSHIPS BETWEEN CALCIUM AND CYCLIC NUCLEOTIDES IN CELL ACTIVATION, PHYSIOLOGICAL REVIEWS 57: 421 (1977).

10.1126/science.170.3956.404

REIMANN, E.M., SEPARATION OF REGULATORY AND CATALYTIC SUBUNITS OF CYCLIC 3',5'-ADENOSINE MONOPHOSPHATE-DEPENDENT PROTEIN KINASE(S) OF RABBIT SKELETAL MUSCLE, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 42: 187 (1971).

RICHMAN, P.G., CONFORMATION-DEPENDENT NITRATION OF PROTEIN ACTIVATOR OF CYCLIC ADENOSINE-3',5'-MONOPHOSPHATE PHOSPHODIESTERASE, BIOCHEMISTRY 17: 928 (1978).

RICHMAN, P.G., INTERACTION OF I-125-LABELED CA2+- DEPENDENT REGULATOR PROTEIN WITH CYCLIC NUCLEOTIDE PHOSPHODIESTERASE AND ITS INHIBITORY PROTEIN, JOURNAL OF BIOLOGICAL CHEMISTRY 253: 6323 (1978).

ROACH, R.J., J CYCLIC NUCLEOTIDE 4: 245 (1978).

ROBISON, G.A., ADENYL CYCLASE AS AN ADRENERGIC RECEPTOR, ANNALS OF THE NEW YORK ACADEMY OF SCIENCES 139: 703 (1967).

ROBINSON, G.A., CYCLIC AMP, ANNUAL REVIEW OF BIOCHEMISTRY 37: 149 (1968).

ROBISON G.A. CYCLIC AMP (1971).

Routledge, L. M., Calcium-Binding Proteins and Calcium Function: 439 (1977).

SAMUELSSON, B, PROSTAGLANDINS, ANNUAL REVIEW OF BIOCHEMISTRY 44: 669 (1975).

SAMUELSSON, B, PROSTAGLANDINS AND THROMBOXANES, ANNUAL REVIEW OF BIOCHEMISTRY 47: 997 (1978).

SCARPA A CALCIUM TRANSPORT CE (1978).

SCHULMAN, H, STIMULATION OF BRAIN MEMBRANE-PROTEIN PHOSPHORYLATION BY CALCIUM AND AN ENDOGENOUS HEAT-STABLE PROTEIN, NATURE 271: 478 (1978).

SCHULMAN, H, CA2+-DEPENDENT PROTEIN-PHOSPHORYLATION SYSTEM IN MEMBRANES FROM VARIOUS TISSUES, AND ITS ACTIVATION BY CALCIUM-DEPENDENT REGULATOR, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 75: 5432 (1978).

SHARMA, R.K., INHIBITION OF CA2+-ACTIVATED CYCLIC NUCLEOTIDE PHOSPHODIESTERASE REACTION BY A HEAT-STABLE INHIBITOR PROTEIN FROM BOVINE BRAIN, JOURNAL OF BIOLOGICAL CHEMISTRY 253: 3575 (1978).

SHARMA, R.K., PURIFICATION AND SUBUNIT STRUCTURE OF BOVINE BRAIN MODULATOR BINDING-PROTEIN, JOURNAL OF BIOLOGICAL CHEMISTRY 254: 4276 (1979).

SHERRY, JMF, ROLES OF CALCIUM AND PHOSPHORYLATION IN REGULATION OF ACTIVITY OF GIZZARD MYOSIN, BIOCHEMISTRY 17: 4411 (1978).

SMITH, E.L., CHEMISTRY AND BIOLOGY OF HISTONES, PHYSIOLOGICAL REVIEWS 50: 159 (1970).

SMOAKE, J.A., CYCLIC 3',5'-NUCLEOTIDE PHOSPHODIESTERASE - DISTRIBUTION AND DEVELOPMENTAL CHANGES OF ENZYME AND ITS PROTEIN ACTIVATOR IN MAMMALIAN-TISSUES AND CELLS, BIOCHIMICA ET BIOPHYSICA ACTA 341: 402 (1974).

SOBNE, K, FEBS LETT 99: 199 (1979).

SRIVASTAVA, A.K., J BIOL CHEM 254: 483 (1979).

STEVENS, F.C., COMPARISON OF CALCIUM-BINDING PROTEINS - BOVINE HEART AND BRAIN PROTEIN ACTIVATORS OF CYCLIC NUCLEOTIDE PHOSPHODIESTERASE AND RABBIT SKELETAL-MUSCLE TROPONIN-C, JOURNAL OF BIOLOGICAL CHEMISTRY 251: 4495 (1976).

STRYER, L, BIOCHEMISTRY-US: 826 (1975).

SUTHERLAND, E.W., ADENYL CYCLASE .1. DISTRIBUTION, PREPARATION, AND PROPERTIES, JOURNAL OF BIOLOGICAL CHEMISTRY 237: 1220 (1962).

Suttie, J. W., Calcium-Binding Proteins and Calcium Function: 313 (1977).

SUZUKI Y UNPUBLISHED.

TAO, M, MECHANISM OF ACTIVATION BY ADENOSINE 3' - 5'-CYCLIC MONOPHOSPHATE OF A PROTEIN PHOSPHOKINASE FROM RABBIT RETICULOCYTES, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 67: 408 (1970).

TEO, T.S., MECHANISM OF ACTIVATION OF A CYCLIC ADENOSINE 3'-5'-MONOPHOSPHATE PHOSPHODIESTERASE FROM BOVINE HEART BY CALCIUM-IONS - IDENTIFICATION OF PROTEIN ACTIVATOR AS A CA2+ BINDING PROTEIN, JOURNAL OF BIOLOGICAL CHEMISTRY 248: 5950 (1973).

TESHIMA, Y, MECHANISM OF STIMULATION OF CA2+ PLUS MG2+-DEPENDENT PHOSPHODIESTERASE FROM RAT CEREBRAL-CORTEX BY MODULATOR PROTEIN AND CA2+, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 56: 489 (1974).

UZUNOV, P, SEPARATION OF MULTIPLE MOLECULAR FORMS OF CYCLIC ADENOSINE-3', PHOSPHODIESTERASE IN RAT CEREBELLUM BY POLYACRYLAMIDE-GEL ELECTROPHORESIS, BIOCHIMICA ET BIOPHYSICA ACTA 284: 220 (1972).

VANAMAN, T.C., CONTRACTILE SYSTEMS: 165 (1976).

VERNA, M.J., PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 76: 184 (1979).

VOGT, W, MEMOIRS SOC ENDOCRIN: 137 (1966).

WAISMAN, D, DISTRIBUTION OF CA++-DEPENDENT PROTEIN ACTIVATOR OF CYCLIC NUCLEOTIDE PHOSPHODIESTERASE IN INVERTEBRATES, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 65: 975 (1975).

WAISMAN, D.M., PURIFICATION AND CHARACTERIZATION OF A CA2+-BINDING PROTEIN IN LUMBRICUS-TERRESTRIS, JOURNAL OF BIOLOGICAL CHEMISTRY 253: 1106 (1978).

WAISMAN, D.M., MODULATOR-DEPENDENT PROTEIN-KINASE - MULTIFUNCTIONAL PROTEIN-KINASE ACTIVATABLE BY CA2+-DEPENDENT MODULATOR PROTEIN OF CYCLIC NUCLEOTIDE SYSTEM, JOURNAL OF BIOLOGICAL CHEMISTRY 253: 3387 (1978).

WALLACE, R.W., ENDOGENOUS INHIBITOR PROTEIN OF BRAIN ADENYLATE-CYCLASE AND CYCLIC NUCLEOTIDE PHOSPHODIESTERASE, ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 187: 328 (1978).

WALLACE, R.W., BIOCH J 183: 285 (1979).

WALLACE, R.W., ANTIBODY AGAINST BOVINE BRAIN CALMODULIN CROSS-REACTS WITH COTTONSEED CALMODULIN, FEDERATION PROCEEDINGS 38: 478 (1979).

WALLACE, R.W., PURIFICATION AND CHARACTERIZATION OF AN INHIBITOR PROTEIN OF BRAIN ADENYLATE-CYCLASE AND CYCLIC NUCLEOTIDE PHOSPHODIESTERASE, JOURNAL OF BIOLOGICAL CHEMISTRY 254: 377 (1979).

WALLACE R.W. UNPUBLISHED.

WALSH, M, CHEMICAL MODIFICATION STUDIES ON CA2+-DEPENDENT PROTEIN MODULATOR OF CYCLIC NUCLEOTIDE PHOSPHODIESTERASE, BIOCHEMISTRY 16: 2742 (1977).

WALSH, M, CHEMICAL MODIFICATION STUDIES ON CA2+-DEPENDENT PROTEIN MODULATOR - ROLE OF METHIONINE RESIDUES IN ACTIVATION OF CYCLIC NUCLEOTIDE PHOSPHODIESTERASE, BIOCHEMISTRY 17: 3924 (1978).

WALSH, M, PREPARATION, CHARACTERIZATION, AND PROPERTIES OF A NOVEL TRIPLE-MODIFIED DERIVATIVE OF CA2+-DEPENDENT PROTEIN MODULATOR, CANADIAN JOURNAL OF BIOCHEMISTRY 56: 420 (1978).

WALSH, M, PURIFICATION AND PROPERTIES OF BOVINE HEART CAL MODULIN-DEPENDENT MYOSIN LIGHT CHAIN KINASE, FEDERATION PROCEEDINGS 38: 789 (1979).

WALSH, M, CHARACTERIZATION OF TRYPTIC FRAGMENTS OBTAINED FROM BOVINE BRAIN PROTEIN MODULATOR OF CYCLIC NUCLEOTIDE PHOSPHODIESTERASE, JOURNAL OF BIOLOGICAL CHEMISTRY 252: 7440 (1977).

WANG, J.H., ADVANCES IN CYCLIC NUCLEOTIDE RESEARCH 5: 179 (1975).

WANG, J.H., BRAIN PROTEIN AND ITS EFFECT ON CA2+- AND PROTEIN MODULATOR-ACTIVATED CYCLIC NUCLEOTIDE PHOSPHODIESTERASE, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 72: 926 (1976).

WANG, J.H., MODULATOR BINDING-PROTEIN - BOVINE BRAIN PROTEIN EXHIBITING CA2+-DEPENDENT ASSOCIATION WITH PROTEIN MODULATOR OF CYCLIC NUCLEOTIDE PHOSPHODIESTERASE, JOURNAL OF BIOLOGICAL CHEMISTRY 252: 4175 (1977).

Wasserman R. H. Calcium-Binding Proteins and Calcium Function (1977).

WASSERMAN, R.H., HDB PHYSL 7 44: 137 (1976).

Watterson, D. M., Journal of Biological Chemistry 255: 962 (1980).

WATTERSON, D.M., STRUCTURAL SIMILARITIES BETWEEN CA-2+-DEPENDENT REGULATORY PROTEINS OF 3'-5'-CYCLIC NUCLEOTIDE PHOSPHODIESTERASE AND ACTOMYOSIN ATPASE, JOURNAL OF BIOLOGICAL CHEMISTRY 251: 4501 (1976).

WEBER, A, MOLECULAR CONTROL MECHANISMS IN MUSCLE-CONTRACTION, PHYSIOLOGICAL REVIEWS 53: 612 (1973).

WELLS, J.N., ADVANCES IN CYCLIC NUCLEOTIDE RESEARCH 8: 119 (1977).

WELSH, M.J., CALCIUM-DEPENDENT REGULATOR PROTEIN - LOCALIZATION IN MITOTIC APPARATUS OF EUKARYOTIC CELLS, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 75: 1867 (1978).

WESTCOTT, K.R., RESOLUTION OF ADENYLATE-CYCLASE SENSITIVE AND INSENSITIVE TO CA2+ AND CALCIUM-DEPENDENT REGULATORY PROTEIN (CDR) BY CDR-SEPHAROSE AFFINITY CHROMATOGRAPHY, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 76: 204 (1979).

WOLFF, D.J., DIVALENT-CATION BINDING PROPERTIES OF BOVINE BRAIN CA2+-DEPENDENT REGULATOR PROTEIN, JOURNAL OF BIOLOGICAL CHEMISTRY 252: 4108 (1977).

WONG, PYK, CALMODULIN STIMULATES HUMAN-PLATELET PHOSPHOLIPASE-A2, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 90: 473 (1979).

Wood, J. G., Journal of Cell Biology 84: 66 (1980).

YAGI, K, IDENTIFICATION OF AN ACTIVATOR PROTEIN FOR MYOSIN LIGHT CHAIN KINASE AS CA2+-DEPENDENT MODULATOR PROTEIN, JOURNAL OF BIOLOGICAL CHEMISTRY 253: 1338 (1978).

YAMAUCHI, T, ACTIVATION OF TRYPTOPHAN 5-MONOOXYGENASE BY CALCIUM-DEPENDENT REGULATOR PROTEIN, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 90: 28 (1979).

YAZAWA, M, CALCIUM-BINDING SUBUNIT OF MYOSIN LIGHT CHAIN KINASE, JOURNAL OF BIOCHEMISTRY 82: 287 (1977).