CD133 Expression and Cancer Stem Cells Predict Prognosis in High‐grade Oligodendroglial Tumors

Brain Pathology - Tập 18 Số 3 - Trang 370-377 - 2008
Dagmar Beier1, Jörg Wischhusen2, Wolfgang Dietmaier3, Peter Hau1, Martin Proescholdt4, Alexander Brawanski4, Gian Domenico Borasio1, Christoph P. Beier1
1Laboratory of Neurooncology, Department of Neurology, University of Regensburg, Medical School, Regensburg, Germany.
2Interdisciplinary Center for Clinical Research, Junior Research Group “Tumor Progression and Immune Escape”, University of Würzburg, Medical School, Clinics for Gynecology and Obstetrics, Würzburg, Germany.
3Department of Pathology. University of Regensburg Medical School, Regensburg, Germany
4Department of Neurosurgery, University of Regensburg, Medical School, Regensburg, Germany

Tóm tắt

AbstractHigh‐grade oligodendroglial tumors, that is, anaplastic oligodendroglial tumors and glioblastomas with oligodendroglial component, differ significantly in terms of prognosis and response to chemotherapy. Differentiation might be difficult because the histological differences are vague and reliable markers are not established. We correlated the presence of putative cancer stem cells (CSC) in high‐grade oligodendroglial tumors (WHO grades III and IV) with clinical outcome. Tumors with favorable prognosis neither contained CSC nor did they show CD133 expression. Tumor cells resembled lineage‐restricted progenitor cells with limited proliferative capacity and differentiation profile. In contrast, CD133 expression and stem cell‐like tumor cells characterized tumors with poor prognosis. They showed neurosphere‐like growth, differentiated into cells of all neural lineages, and were tumorigenic in nude mice. In our series, CSC and expression of CD133 predicted the clinical course of disease better than the histological grading. To confirm these results, we retrospectively analyzed 36 high‐grade oligodendroglial tumors. Again, CD133 expression indicated shorter survival and predicted clinical outcome more reliable than the histological assessment.Our data show that detection of CSC and expression of CD133 is predictive of prognosis in high‐grade oligodendroglial tumors. The presence or absence of CD133+ CSC might explain the crucial biological difference between WHO grade III and IV oligodendroglial tumors.

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Tài liệu tham khảo

10.1038/nature05236

10.1158/0008-5472.CAN-06-4180

10.1038/nrc1740

10.1002/ana.410230408

10.1016/j.bbmt.2004.11.011

10.1016/j.bbmt.2004.11.004

10.1073/pnas.2036535100

10.1002/cncr.21819

10.1007/s004150070175

10.1111/j.1768-322X.2004.tb01416.x

10.1007/s00401-007-0243-4

10.1016/j.tins.2003.12.007

Nutt CL, 2003, Gene expression‐based classification of malignant gliomas correlates better with survival than histological classification, Cancer Res, 63, 1602

10.1038/nature05349

10.1007/s00109-004-0564-x

10.1038/35102167

10.1182/blood-2002-03-0755

10.1038/nature03128

10.1056/NEJMoa043330

10.1073/pnas.97.26.14720

10.1200/JCO.2005.04.6078

10.1038/modpathol.3800942

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Brain Pathology

Tập 18 Số 3

370-377

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