CCL7 and TGF-β secreted by MSCs play opposite roles in regulating CRC metastasis in a KLF5/CXCL5-dependent manner

Molecular Therapy - Tập 30 - Trang 2327-2341 - 2022
Zhuoqing Xu1,2, Han Gao1,2, Yuchen Zhang1,2, Wenqing Feng1,2, Yiming Miao1, Zifeng Xu1,2, Wenchang Li1, Fangqian Chen1, Zeping Lv1, Jianting Huo1,2, Wangyi Liu1,2, Xiaohui Shen1, Yaping Zong1, Jingkun Zhao1, Aiguo Lu1
1Department of General Surgery, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200025, PR China
2Shanghai Institute of Digestive Surgery, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200025, PR China

Tài liệu tham khảo

Siegel, 2020, Cancer statistics, 2020, CA Cancer J. Clin., 70, 7, 10.3322/caac.21590 Bussard, 2016, Tumor-associated stromal cells as key contributors to the tumor microenvironment, Breast Cancer Res., 18, 84, 10.1186/s13058-016-0740-2 Wang, 2014, Chemokine signaling in development and disease, Development, 141, 4199, 10.1242/dev.101071 Zhao, 2017, Tumor-derived CXCL5 promotes human colorectal cancer metastasis through activation of the ERK/Elk-1/Snail and AKT/GSK3beta/beta-catenin pathways, Mol. Cancer, 16, 70, 10.1186/s12943-017-0629-4 Xia, 2015, The potential of CXCL5 as a target for liver cancer - what do we know so far?, Expert Opin. Ther. Targets, 19, 141, 10.1517/14728222.2014.993317 Chen, 2019, CXCL5 induces tumor angiogenesis via enhancing the expression of FOXD1 mediated by the AKT/NF-kappaB pathway in colorectal cancer, Cell Death Dis., 10, 178, 10.1038/s41419-019-1431-6 Cuiffo, 2012, Mesenchymal stem cells in tumor development: emerging roles and concepts, Cell Adh. Migr., 6, 220, 10.4161/cam.20875 Prockop, 2010, Defining the risks of mesenchymal stromal cell therapy, Cytotherapy, 12, 576, 10.3109/14653249.2010.507330 Zhang, 2018, Human colorectal cancer-derived mesenchymal stem cells promote colorectal cancer progression through IL-6/JAK2/STAT3 signaling, Cell Death Dis., 9, 25, 10.1038/s41419-017-0176-3 Luo, 2018, Mesenchymal stem cells promote cell invasion and migration and autophagy-induced epithelial-mesenchymal transition in A549 lung adenocarcinoma cells, Cell Biochem. Funct., 36, 88, 10.1002/cbf.3320 Prantl, 2010, Adipose tissue-derived stem cells promote prostate tumor growth, Prostate, 70, 1709, 10.1002/pros.21206 Chaturvedi, 2013, Hypoxia-inducible factor-dependent breast cancer-mesenchymal stem cell bidirectional signaling promotes metastasis, J. Clin. Invest., 123, 189, 10.1172/JCI69244 Borriello, 2017, Cancer-associated fibroblasts share characteristics and protumorigenic activity with mesenchymal stromal cells, Cancer Res., 77, 5142, 10.1158/0008-5472.CAN-16-2586 Pelon, 2020, Cancer-associated fibroblast heterogeneity in axillary lymph nodes drives metastases in breast cancer through complementary mechanisms, Nat. Commun., 11, 404, 10.1038/s41467-019-14134-w Poggi, 2018, How to hit mesenchymal stromal cells and make the tumor microenvironment immunostimulant rather than immunosuppressive, Front. Immunol., 9, 262, 10.3389/fimmu.2018.00262 Calloni, 2013, Reviewing and updating the major molecular markers for stem cells, Stem Cells Dev., 22, 1455, 10.1089/scd.2012.0637 Shi, 2017, Tumour-associated mesenchymal stem/stromal cells: emerging therapeutic targets, Nat. Rev. Drug Discov., 16, 35, 10.1038/nrd.2016.193 Harrell, 2020, Therapeutic use of mesenchymal stem cell-derived exosomes: from basic science to clinics, Pharmaceutics, 12, 10.3390/pharmaceutics12050474 Mishra, 2011, Chemokines at the crossroads of tumor-fibroblast interactions that promote malignancy, J. Leukoc. Biol., 89, 31, 10.1189/jlb.0310182 Zlotnik, 2012, The chemokine superfamily revisited, Immunity, 36, 705, 10.1016/j.immuni.2012.05.008 Zhao, 2018, C5a induces A549 cell proliferation of non-small cell lung cancer via GDF15 gene activation mediated by GCN5-dependent KLF5 acetylation, Oncogene, 37, 4821, 10.1038/s41388-018-0298-9 Zhang, 2021, Acetylation of KLF5 maintains EMT and tumorigenicity to cause chemoresistant bone metastasis in prostate cancer, Nat. Commun., 12, 1714, 10.1038/s41467-021-21976-w Liu, 2020, Chromatin looping shapes KLF5-dependent transcriptional programs in human epithelial cancers, Cancer Res., 80, 5464, 10.1158/0008-5472.CAN-20-1287 Wang, 2013, Transcriptional/epigenetic regulator CBP/p300 in tumorigenesis: structural and functional versatility in target recognition, Cell Mol. Life Sci., 70, 3989, 10.1007/s00018-012-1254-4 Wang, 2018, Targeting lineage-specific MITF pathway in human melanoma cell lines by A-485, the selective small-molecule inhibitor of p300/CBP, Mol. Cancer Ther., 17, 2543, 10.1158/1535-7163.MCT-18-0511 Serra, 2007, Functional interdependence at the chromatin level between the MKK6/p38 and IGF1/PI3K/AKT pathways during muscle differentiation, Mol. Cell, 28, 200, 10.1016/j.molcel.2007.08.021 Su, 2015, Interleukin-1beta/Iinterleukin-1 receptor-associated kinase 1 inflammatory signaling contributes to persistent Gankyrin activation during hepatocarcinogenesis, Hepatology, 61, 585, 10.1002/hep.27551 Siraj, 2019, zz in CRC, Mol. Cancer Ther., 18, 1312, 10.1158/1535-7163.MCT-18-1378 David, 2016, TGF-beta tumor suppression through a lethal EMT, Cell, 164, 1015, 10.1016/j.cell.2016.01.009 Zhang, 2010, Antimetastatic role of Smad4 signaling in colorectal cancer, Gastroenterology, 138, 969, 10.1053/j.gastro.2009.11.004 Melisi, 2008, LY2109761, a novel transforming growth factor beta receptor type I and type II dual inhibitor, as a therapeutic approach to suppressing pancreatic cancer metastasis, Mol. Cancer Ther., 7, 829, 10.1158/1535-7163.MCT-07-0337 Itatani, 2013, Loss of SMAD4 from colorectal cancer cells promotes CCL15 expression to recruit CCR1+ myeloid cells and facilitate liver metastasis, Gastroenterology, 145, 1064, 10.1053/j.gastro.2013.07.033 Lakshmi, 2017, Transforming growth factor beta suppresses peroxisome proliferator-activated receptor gamma expression via both SMAD binding and novel TGF-beta inhibitory elements, Biochem. J., 474, 1531, 10.1042/BCJ20160943 Poggi, 2016, Mesenchymal stromal cells can regulate the immune response in the tumor microenvironment, Vaccines (Basel), 4 Hosein, 2020, Pancreatic cancer stroma: an update on therapeutic targeting strategies, Nat. Rev. Gastroenterol. Hepatol., 17, 487, 10.1038/s41575-020-0300-1 Ouahoud, 2020, Bidirectional tumor/stroma crosstalk promotes metastasis in mesenchymal colorectal cancer, Oncogene, 39, 2453, 10.1038/s41388-020-1157-z Melzer, 2016, Interaction of MSC with tumor cells, Cell Commun. Signal., 14, 20, 10.1186/s12964-016-0143-0 He, 2019, MSC-regulated lncRNA MACC1-AS1 promotes stemness and chemoresistance through fatty acid oxidation in gastric cancer, Oncogene, 38, 4637, 10.1038/s41388-019-0747-0 Cuiffo, 2014, MSC-regulated microRNAs converge on the transcription factor FOXP2 and promote breast cancer metastasis, Cell Stem Cell, 15, 762, 10.1016/j.stem.2014.10.001 Karnoub, 2007, Mesenchymal stem cells within tumour stroma promote breast cancer metastasis, Nature, 449, 557, 10.1038/nature06188 Waghray, 2016, GM-CSF mediates mesenchymal-epithelial cross-talk in pancreatic cancer, Cancer Discov., 6, 886, 10.1158/2159-8290.CD-15-0947 Lin, 2013, Colon cancer mesenchymal stem cells modulate the tumorigenicity of colon cancer through interleukin 6, Exp. Cell Res., 319, 2216, 10.1016/j.yexcr.2013.06.003 Qiao, 2008, Dkk-1 secreted by mesenchymal stem cells inhibits growth of breast cancer cells via depression of Wnt signalling, Cancer Lett., 269, 67, 10.1016/j.canlet.2008.04.032 Lu, 2008, The growth inhibitory effect of mesenchymal stem cells on tumor cells in vitro and in vivo, Cancer Biol. Ther., 7, 245, 10.4161/cbt.7.2.5296 Thomas, 2019, CC chemokines are differentially expressed in Breast Cancer and are associated with disparity in overall survival, Sci. Rep., 9, 4014, 10.1038/s41598-019-40514-9 Sharma, 2017, Gene expression profiling of chemokines and their receptors in low and high grade Astrocytoma, Asian Pac. J. Cancer Prev., 18, 1307 Korbecki, 2020, CC chemokines in a tumor: a review of pro-cancer and anti-cancer properties of the ligands of receptors CCR1, CCR2, CCR3, and CCR4, Int. J. Mol. Sci., 21 Jung, 2010, Tumor-stromal crosstalk in invasion of oral squamous cell carcinoma: a pivotal role of CCL7, Int. J. Cancer, 127, 332, 10.1002/ijc.25060 Liu, 2016, Cancer-associated fibroblasts promote hepatocellular carcinoma metastasis through chemokine-activated hedgehog and TGF-beta pathways, Cancer Lett., 379, 49, 10.1016/j.canlet.2016.05.022 McConnell, 2010, Mammalian Kruppel-like factors in health and diseases, Physiol. Rev., 90, 1337, 10.1152/physrev.00058.2009 Jia, 2016, KLF5 promotes breast cancer proliferation, migration and invasion in part by upregulating the transcription of TNFAIP2, Oncogene, 35, 2040, 10.1038/onc.2015.263 Wu, 2019, CINP is a novel cofactor of KLF5 required for its role in the promotion of cell proliferation, survival and tumor growth, Int. J. Cancer, 144, 582, 10.1002/ijc.31908 Caja, 2018, TGF-beta and the tissue microenvironment: relevance in fibrosis and cancer, Int. J. Mol. Sci., 19, 10.3390/ijms19051294 Zhao, 2018, Knockdown of TGF-beta1 expression in human umbilical cord mesenchymal stem cells reverts their exosome-mediated EMT promoting effect on lung cancer cells, Cancer Lett., 428, 34, 10.1016/j.canlet.2018.04.026 Chen, 2020, Dysregulated PJA1-TGF-beta signaling in cancer stem cell-associated liver cancers, Oncoscience, 7, 88, 10.18632/oncoscience.522 Seoane, 2017, TGF-beta family signaling in tumor suppression and cancer progression, Cold Spring Harb. Perspect. Biol., 9, 10.1101/cshperspect.a022277 Derynck, 2003, Smad-dependent and Smad-independent pathways in TGF-beta family signalling, Nature, 425, 577, 10.1038/nature02006 Feng, 2005, Specificity and versatility in tgf-beta signaling through Smads, Annu. Rev. Cell Dev. Biol., 21, 659, 10.1146/annurev.cellbio.21.022404.142018 Diakiw, 2013, The double life of KLF5: opposing roles in regulation of gene-expression, cellular function, and transformation, IUBMB Life, 65, 999, 10.1002/iub.1233