Broad-Spectrum Antiviral Activity of Virazole: 1-β-D-Ribofuranosyl-1,2,4-triazole-3-carboxamide

American Association for the Advancement of Science (AAAS) - Tập 177 Số 4050 - Trang 705-706 - 1972
Robert W. Sidwell1, John H. Huffman1, Lois G. P. Khare1, B. Allen1, Roland J. T. Witkowski1, K. Robins1
1ICN Nucleic Acid Research Institute, Irvine, California 92664

Tóm tắt

Virazole is a synthetic nucleoside active in tissue culture against at least 16 DNA and RNA viruses. Applied topically, it inhibits herpetic keratitis in rabbits and tail lesions induced by herpes, vaccinia, and vesicular stomatitis viruses in mice. Injected intraperitoneally into mice, it inhibits splenomegaly and hepatomegaly induced by Friend leukemia virus and respiratory infections caused by influenza A 0 , A 2 , and B viruses and parainfluenza 1 virus. Oral or aerosol treatment of parainfluenza virus infections is also effective.

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Tài liệu tham khảo

COHEN, S. S., Introduction to the Biochemistry of D-Arabinosyl Nucleosides, PROGRESS IN NUCLEIC ACID RESEARCH AND MOLECULAR BIOLOGY 5: 1 (1966).

CORWIN, M.E., EFFECT OF IUDR AND AMETHOPTERIN ON EXPERIMENTAL HERPES-SIMPLEX KERATITIS, INVESTIGATIVE OPHTHALMOLOGY 2: 578 (1963).

ERHLICH, J, ANN NY ACAD SCI 130: 5 (1965).

Khare G. P. in preparation.

MANN, H.B., ON A TEST OF WHETHER ONE OF 2 RANDOM VARIABLES IS STOCHASTICALLY LARGER THAN THE OTHER, ANNALS OF MATHEMATICAL STATISTICS 18: 50 (1947).

MIDDLEBROOK, G, AN APPARATUS FOR AIRBORNE INFECTION OF MICE, PROCEEDINGS OF THE SOCIETY FOR EXPERIMENTAL BIOLOGY AND MEDICINE 80: 105 (1952).

SIDWELL, R.W., USE OF DIPOSABLE MICRO TISSUE CULTURE PLATES FOR ANTIVIRAL AND INTERFERON INDUCTION STUDIES, APPLIED MICROBIOLOGY 22: 797 (1971).

SIDWELL, R. W., CANCER CHEMOTHERAPY REPORTS 50: 299 (1966).

Witkowski J. T. Abstracts. 163rd Meeting American Chemical Society (1972).

YOSHIMURA, S, PROGRESS IN ANTIMICROBIAL AND ANTICANCER CHEMOTHERAPY 1: 481 (1970).

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American Association for the Advancement of Science (AAAS)

Tập 177 Số 4050

705-706

Thông tin tác giả