Breast‐feeding, a complex support system for the offspring

Pediatrics International - Tập 44 Số 4 - Trang 347-352 - 2002
Lars Å. Hanson1, Marina Korotkova1,2, Liliana Håversen3, Inger Mattsby‐Baltzer3, Mirjana Hahn‐Zoric4, Sven‐Arne Silfverdal2, Birgitta Strandvik2, Esbjörn Telemo3
1Departments of Clinical Immunology
2Pediatrics, Göteborg University, Göteborg and
3Clinical Bacteriology and
4Department of Pediatrics, Örebro Medical Center Hospital, Örebro, Sweden

Tóm tắt

AbstractThe newborn has an immune system, very limited in size at birth and its postnatal expansion and maturation takes time. In the meantime the transplacental IgG antibodies from the mother play an important role for the protection of the infant. However, these antibodies act in tissues and induce inflammation and are energy‐consuming. In contrast, the milk secretory IgA antibodies stop microbes already on the mucosa preventing infection, tissue engagement and energy loss. In addition, the milk contains many protective factors such as lactoferrin and oligosacharides functioning as analogues for microbial receptors preventing mucosal attachment, the initial step of most infections. As a result, breast‐feeding significantly reduces the risk of neonatal septicemia, respiratory tract infections, otitis media, diarrhea, urinary tract infections, infection‐induced wheezing and necrotizing enterocolitis. Via several mechanisms it seems that human milk can actively stimulate the immune system of the breast‐fed infant. This reduces the risk of infections like otitis media, respiratory tract infections, diarrhea and infection‐induced wheezing for several years after the termination of breast‐feeding. Furthermore, it seems that breast‐feeding decreases the risk of attracting celiac disease and allergic diseases. The latter has been much debated, but a recent critical review of published reports gives good support for long‐term protection of allergic diseases, especially in high‐risk children.

Từ khóa


Tài liệu tham khảo

10.1016/S0167-5699(99)01473-5

10.1203/00006450-200012000-00007

Adlerberth I, 1999, Development of the Gastrointestinal Tract., 279

Wannemuehler MJ, 1982, Lipopolysaccharide (LPS) regulation of the immune response: LPS converts germfree mice to sensitivity to oral tolerance induction, J. Immunol., 129, 959, 10.4049/jimmunol.129.3.959

10.1111/j.1651-2227.1998.tb00972.x

Goldblum R, 1996, Immunological Disorders in Infants and Children, 159

10.1016/S1081-1206(10)62704-4

10.1056/NEJM198306093082304

10.1111/j.1651-2227.1988.tb10726.x

10.1016/S0022-3476(05)82652-6

10.1016/S0022-3476(05)80327-0

Walterspiel JN, 1994, Secretory anti‐Giardia lamblia antibodies in human milk: protective effect against diarrhea, Pediatrics, 93, 28, 10.1542/peds.93.1.28

10.1128/IAI.68.10.5816-5823.2000

10.1203/00006450-199003000-00009

HåversenLA BaltzerL DolphinG HansonLÅ Mattsby‐BaltzerI.Anti‐inflammatory activities of human lactoferrin and synthetic peptides thereof in experimental dextran‐sulphate induced colitis in mice.Scand. J. Immunol.2002 in press.

10.1093/infdis/153.2.232

10.1111/j.1753-4887.2000.tb07801.x

10.1046/j.1365-2249.1999.00782.x

10.1016/S0140-6736(97)10322-1

Hanson LÅ, 1999, Mucosal Immunology, 1501

10.1136/adc.66.4.488

10.1111/j.1651-2227.1982.tb09476.x

10.1136/bmj.316.7124.21

10.1136/adc.68.6.724

10.1136/bmj.300.6716.11

10.1136/thorax.56.3.192

OddyWH De KlerkNH HoltPG SlyPD.Maternal asthma infant feeding and the recurrent wheeze and risk of asthma in childhood.Eur. Resp. J.2002;in press.

10.1007/978-1-4615-0559-4_11

10.1097/00007890-199111000-00032

10.1097/00007890-198404000-00004

10.1016/0022-4804(84)90166-5

Tuboly S, 1995, Intestinal absorption of colostral lymphocytes in newborn lambs and their role in the development of immune status, Acta. Vet. Hung., 43, 105

10.1203/00006450-199305000-00011

10.1084/jem.160.4.1001

Okamoto Y, 1989, Effect of breast feeding on the development of anti‐idiotype antibody response to F glycoprotein of respiratory syncytial virus in infant mice after post‐partum maternal immunization, J. Immunol., 142, 2507, 10.4049/jimmunol.142.7.2507

SilfverdalSE BodinL UlanovaM Hahn‐ZoricM HansonLÅ OlcenP.Long‐term enhancement of the IgG2 antibody response toHaemophilus influenzaetype b by breastfeeding.Pediatr. Inf. Dis J.2002;in press.

10.1203/00006450-200001000-00026

10.1126/science.8009224

10.1111/j.1651-2227.1996.tb14211.x

10.1034/j.1398-9995.2001.00040.x

10.1016/S0031-3955(05)70289-3

IvarssonA HernellO StenlundH PerssonLÅ.Breast‐feeding protects against celiac disease.Am. J. Clin. Nutr.2002; in press.

10.1136/bmj.298.6688.1617

10.1136/bmj.302.6792.1580

10.1016/S0022-3476(88)80054-4

10.1136/bmj.310.6989.1225

10.1136/bmj.319.7203.147

10.1016/S0140-6736(00)04004-6

10.1152/ajpcell.1992.263.1.C114

10.1126/science.271.5249.665

10.1172/JCI119207

10.1203/00006450-199807000-00006

10.1046/j.1440-1711.2000.00882.x

10.1016/S0091-6749(99)70021-7

10.1210/jcem.82.12.4590

10.1515/JPEM.2000.13.2.149

10.1111/j.1651-2227.1986.tb10275.x

10.1111/j.1651-2227.1990.tb11501.x

Chowdhury AKMA, 1978, The Effects of Infant and Child Mortality on Fertility., 17

UNICEF., 1987, The State of the World's Children.

Thông tin
Thông tin xuất bản

Pediatrics International

Tập 44 Số 4

347-352

Thông tin tác giả