Breast Cancer Close to the Nipple: Does This Increase the Risk of Nodal Metastasis at Diagnosis?

Canadian Association of Radiologists Journal - Tập 62 - Trang 209-214 - 2011
Erin I. Lewis1, Al Ozonoff2, Cheri P. Nguyen3, Michael Kim1, Priscilla J. Slanetz4
1Department of Radiology, Boston University Medical Center and Boston University School of Medicine, Boston, Massachusetts, USA
2Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, USA
3Department of Radiology, Baystate Medical Center, Springfield, Massachusetts, USA
4Division of Breast Imaging, Department of Radiology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, USA

Tóm tắt

Background Previous studies of patients with invasive breast cancer examined, with mixed results, tumour location as a predictor of axillary lymph node metastasis. This study assessed whether tumour location in relation to the nipple impacts the presence of axillary lymph node metastasis at the time of diagnosis. Methods A retrospective review was undertaken of the medical records and available imaging of 285 patients diagnosed with invasive breast cancer between January 2001 to June 2007 at Boston University Medical Center. The incidence of axillary lymph node metastasis was correlated with tumour location in relation to the posterior nipple line to control for variation in breast size. Bivariate analysis identified significant variables that were applied to a multiple logistic regression model. Results Axillary lymph node metastasis was not significantly associated with tumour proximity to the nipple. In the multivariate logistic regression analysis, known prognostic factors for axillary metastasis, such as surgical size, lymphovascular invasion, and age of diagnosis, were significant, whereas breast density, palpability, and histologic grade were no longer significant. Conclusions Our study found that there was no evidence that correlates intramammary tumour proximity to the nipple with the presence of axillary lymph node metastasis at diagnosis. However, known prognostic factors, such as lymphovascular invasion, surgical size, and younger age at diagnosis, are strong independent predictors for axillary lymph node involvement.

Tài liệu tham khảo

10.1002/ijc.11116 10.1002/(SICI)1097-0142(19990401)85:7<1530::AID-CNCR14>3.0.CO;2-U 10.1023/A:1020231300974 10.1002/(SICI)1097-0142(19980901)83:5<948::AID-CNCR21>3.0.CO;2-U 10.1046/j.1524-4741.2003.09107.x 10.1016/S0360-3016(00)00605-2 10.1245/ASO.2003.05.020 10.1007/s10434-001-0432-7 10.1007/s00432-003-0465-3 10.1016/j.breast.2008.10.004 10.1200/JCO.1998.16.4.1363 10.1016/j.ejso.2005.12.009 10.1007/s10434-001-0837-3 American College of Radiology (ACR) Mammography American College of Radiology (ACR) Breast Imaging Reporting and Data System Atlas (BI-RADS Atlas) 4th ed. 2003 American College of Radiology Reston (VA) 179–192. 10.1200/JCO.2005.06.052 10.1002/(SICI)1096-9098(199705)65:1<34::AID-JSO7>3.0.CO;2-P 10.1002/cncr.10229 10.1200/JCO.2000.18.15.2828 10.1200/JCO.2003.12.047 10.1007/s10549-006-9256-2 10.1177/030089160609200509 10.1007/s00464-008-9809-z 10.1007/s00268-001-0006-7 10.3816/CBC.2002.n.013
Thông tin
Thông tin xuất bản

Canadian Association of Radiologists Journal

Tập 62

209-214

Thông tin tác giả