Brassinosteroids Regulate Dissociation of BKI1, a Negative Regulator of BRI1 Signaling, from the Plasma Membrane

American Association for the Advancement of Science (AAAS) - Tập 313 Số 5790 - Trang 1118-1122 - 2006
Xuelu Wang1, Joanne Chory1
1Howard Hughes Medical Institute and Plant Biology Laboratory, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037 USA

Tóm tắt

Brassinosteroids, the steroid hormones of plants, are perceived at the plasma membrane by a leucine-rich repeat receptor serine/threonine kinase called BRI1. We report a BRI1-interacting protein, BKI1, which is a negative regulator of brassinosteroid signaling. Brassinosteroids cause the rapid dissociation of BKI1–yellow fluorescent protein from the plasma membrane in a process that is dependent on BRI1-kinase. BKI1 is a substrate of BRI1 kinase and limits the interaction of BRI1 with its proposed coreceptor, BAK1, suggesting that BKI1 prevents the activation of BRI1.

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Tài liệu tham khảo

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Materials and methods are available as supporting material on Science Online.

This work was supported by a grant from the National Research Initiative of USDA Cooperative State Research Education and Extension Service to J.C. and the Howard Hughes Medical Institute (HHMI). We thank T. Asami (RIKEN) for providing BRZ220 Y. Yin for providing BES1 antibody T. Mockler and J. Meisenhelder for comments on the manuscript and P. Wigge and D. Weigel for originally providing the yeast two-hybrid library. J.C. is an investigator of HHMI.

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American Association for the Advancement of Science (AAAS)

Tập 313 Số 5790

1118-1122

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