Bone resorption in cholesteatoma: Epithelial‐mesenchymal cell interaction and collagenase production

Laryngoscope - Tập 97 Số 7 - Trang 854-859 - 1987
Hiroshi Moriyama1, Yoshio Honda1, Cheng Chun Huang2, Maxwell Abramson2
1Tokyo, Japan
2New York, NY

Tóm tắt

AbstractClinical evidence has shown that chronic otitis media with cholestentoma causes greater bone resorption than otitis media without cholesteatoma. What is the role of the epithelium and its products on the morbidity of cholesteatoma? We have studied the mechanism of collagenase production in cultures of rat epidermal cells and skin fibroblast‐like cells under various conditions. The epithelial cells significantly induced mesenchymal cells to produce collagenase. We conclude that interaction between epithelial cells and fibroblast‐like cells enhances production of collagenase. This enhancement of proteolytic activity may be crucial in the series of molecular events resulting in bone resorption associated with cholesteatoma.

Từ khóa


Tài liệu tham khảo

10.1007/BF00457922

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Laryngoscope

Tập 97 Số 7

854-859

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