Bone loss: Epidemiology of bone loss

Springer Science and Business Media LLC - Tập 2 - Trang 1-5 - 2000
David J Hunter1, Philip N Sambrook1
1Royal North Shore Hospital, Sydney, Australia

Tóm tắt

Bone loss occurs when the cellular events of bone formation are quantitatively larger than bone formation. This manuscript discusses the measurement of bone loss, occurrence in the population, risk factors and consequences of bone loss. Recent developments in bone mass measurement and biomarkers have improved our ability to assess bone loss. This process is a normal concomitant of ageing. There are a number of other risk factors, including sex hormone deficiency, physical inactivity, calcium/vitamin D deficiency, inflammatory arthritis, corticosteroids, smoking and alcohol. The major consequence of bone loss in our ageing society is fracture.

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Tài liệu tham khảo

Pacifici R, Susman N, Carr PL, Birge SJ, Avioli LV: Single and dual energy tomographic analysis of spinal trabecular bone: a comparative study of normal and osteoporotic women. J Clin Endocrinol Metabol . 1987, 64: 209-214.

Parfitt AM: Age related structural changes in trabecular and cortical bone: cellular mechanisms and biomechanical consequences. Calcif Tissue Int. 1984, 36: 122-128.

Grampp S, Genant HK, Mathur A, Lang P, Jergas M, Takada M, Gluer CC, Lu Y, Chavez M: Comparisons of noninvasive bone mineral measurements in assessing age-related loss, fracture discrimination, and diagnostic classification. J Bone Min Res. 1997, 12: 697-711.

Uebelhardt D, Schleemer A, Johansen JS, Gineyts E, Christiansen C, Delmas PD: Effect of menopause and hormone replacement therapy on the urinary excretion of pyridinium crosslinks. J Clin Endocrinol Metab . 1991, 72: 367-373.

Garnero P, Sornay-Rendu E, Chapuy MC, Delmas PD: Increased bone turnover in late postmenopausal women is a major determinant of osteoporosis. J Bone Min Res. 1996, 3: 337-349.

Christiansen C, Riis BJ, Rodbro P: Prediction of rapid bone loss in postmenopausal women. Lancet. 1987, i: 1105-1108.

Falch JA, Sandvik L, van Beresteijn ECH: Development and evaluation of an index to predict early postmenopausal loss. Bone . 1992, 13: 337-341.

Bauer DC, Sklarin PM, Stone KL, Black DM, Nevitt MC, Ensrud KE, Arnaud CD, Genant HK, Garnero P, Delmas PD, Lawaetz H, Cummings SR: Biochemical markers of bone turnover and prediction of hip bone loss in older women: the study of osteoporotic fractures. J Bone Min Res . 1999, 14: 1404-1410.

Riggs BL, Wahner HW, Melton LJ, Richelson LS, Judd HL, Offord KP: Rates of bone loss in the appendicular and axial skeletons of women: evidence of substantial vertebral bone loss before menopause. J Clin Invest. 1986, 77: 1487-1491.

Riggs BL, Wahner HW, Seeman E, Offord KP, Dunn WL, Mazess RB, Johnson KA, Melton LJ: Changes in bone mineral density of the proximal femur and spine with ageing: differences between the postmenopausal and senile osteoporosis syndromes. J Clin Invest. 1982, 70: 716-723.

Riggs BL, Wahner HW, Dunn WL, Mazess RB, Offord KP, Melton LJ: Differential changes in bone mineral density of the appendicular and axial skeleton with ageing. J Clin Invest. 1981, 67: 328-335.

Lindsay R: Prevention of osteoporosis. Clin Orthop . 1987, 222: 44-59.

Eastell R, Wahner HW, O'Fallon WM, Amadio PC, Melton LJ, Riggs BL: Unequal decrease in bone density of lumbar spine and ultra-distal radius in Colles' and vertebral fracture syndromes. J Clin Invest . 1989, 83: 168-174.

Liu G, Chou T, Seeman E: Age-related changes in the proportions of cortical and trabecular bone of the vertebral body and proximal femur. In Proceedings of the Annual Meeting of the Australian/New Zealand Bone Mineral Society.Bone Min Res. 1992, 67:

Riggs BL, Melton LJ: Involutional osteoporosis. N Engl J Med. 1986, 314: 1676-1686.

Riis BJ: The role of bone loss. Am J Med. 1995, 98: 29S-32S.

Pocock NA, Eisman JA, Hopper JL, Yeates MG, Sambrook PN, Eberl S: Genetic determinants of bone mass in adults: a twin study. J Clin Invest. 1987, 80: 706-710.

Slemenda CW, Christian JC, Reed T, Reister TK, Williams CJ, John-ston CC: Long term bone loss in men: Effects of genetic and environmental factors. Ann Intern Med. 1992, 117: 286-291.

Kelly PJ, Hopper JL, Macaskill GT, Pocock NA, Sambrook PN, Eisman JA: Genetic factors in bone turnover. J Clin Endocrinol Metab . 1991, 72: 808-813.

Kelly PJ, Nguyen T, Hopper J, Pocock N, Sambrook P, Eisman J: Changes in axial bone density with age: a twin study. J Bone Min Res. 1993, 8: 11-17.

Riggs BL, Melton LJ: The prevention and treatment of osteoporosis. N Engl J Med. 1993, 328: 460-464.

Stone K, Bauer DC, Black DM, Sklarin P, Ensrud KE, Cummings SR: Hormonal predictors of bone loss in elderly women: a prospective study. J Bone Min Res. 1998, 13: 1167-1174.

Jones G, Nguyen T, Sambrook P, Kelly PJ, Eisman JA: Progressive loss of bone in the femoral neck in elderly people: longitudinal findings from the Dubbo osteoporosis epidemiology study. Br Med J. 1994, 309: 691-695.

Ensrud KE, Palermo L, Black DM, Cauley J, Jergas M, Orwoll ES, Nevitt MC, Fox KM, Cummings SR: Hip and calcaneal bone loss increase with advancing age: longitudinal results from the study of osteoporotic fractures. J Bone Min Res. 1995, 10: 1778-1787.

Riggs BL, Khosla S, Melton LJ: A unitary model for involutional osteoporosis: Estrogen deficiency causes both Type 1 and Type 2 osteoporosis in postmenopausal women and contributes to bone loss in ageing men. J Bone Min Res. 1998, 13: 763-773.

Nguyen TV, Sambrook PN, Eisman JA: Bone loss, physical activity, and weight change in elderly women: the Dubbo osteoporosis epidemiology study. J Bone Min Res. 1998, 13: 1458-1467.

Frost HM: On our age-related bone loss: insights from a new paradigm. J Bone Min Res. 1997, 12: 1539-1546.

Citron JT, Ettinger B, Genant HK: Spinal bone mineral loss in estrogen-replete, calcium-replete premenopausal women. Osteoporosis Int. 1995, 5: 228-233.

Reid IR, Ames RW, Evans MC, Gamble GD, Sharpe SJ: Effect of calcium supplementation on bone loss in postmenopausal women. N Engl J Med. 1993, 328: 460-464.

Dawson Hughes B, Dallal GE, Krall EA, Sadowski L, Sahyoun N, Tan-nenbaum S: A controlled trial of the effect of calcium supplements on bone density in postmenopausal women. N Engl J Med. 1990, 323: 878-883.

Chapuy MC, Arlot ME, Dubeof F, Brun J, Crouzet B, Arnaud S, Delmas PD, Meunier PJ: Vitamin D3 and calcium to prevent hip fractures in elderly women. N Engl J Med. 1992, 327: 1637-1642.

Gough AK, Lilley J, Eyre S, Holder PL, Emery P: Generalised bone loss in patients with early rheumatoid arthritis. Lancet. 1995, 344: 23-27.

Sambrook PN, Jones G: Corticosteroid osteoporosis. Br J Rheumatol. 1995, 34: 8-12.

Baron JA: Smoking and estrogen related disease. Am J Epidemiol. 1984, 119: 9-22.

Ensrud KE, Lipschutz RC, Cauley JA, Seeley D, Nevitt MC, Scott J, Orwoll ES, Genant HK, Cummings SR: Body size and hip fracture risk in older women: a prospective study. Study of Osteoporotic Fractures Research Group. Am J Med. 1997, 103: 274-280.

Ensrud KE, Cauley J, Lipschutz R, Cummings SR: Weight change and fractures in older women. Study of Osteoporotic Fractures Research Group. Arch Int Med. 1997, 157: 857-863.

Miller KK, Klibanski A: Amenorrheic bone loss. J Clin Endocrin Metab. 1999, 84: 1775-1783.

Ooms ME, Vlasman P, Lips P, Nauta J, Bouter LM, Valkenburg HA: The incidence of hip fractures in independent and institutionalised people. Osteoporosis Int. 1994, 4: 6-10.

Melton LJ, Lane AW, Cooper C, Eastell R, O'Fallon WH, Riggs BL: Prevalence and incidence of vertebral deformities. Osteoporosis Int. 1993, 3: 113-119.

Eastell R, Robins SP, Colwell T, Assiri AMA, Riggs BL, Russell RGG: Evaluation of bone turnover in type 1 osteoporosis using biochemical markers specific for bone formation and bone resorption. Osteoporosis Int. 1993, 3: 255-260.

Eriksen EF, Hodgson SF, Eastell R, Cedel SL, O'Fallon WM, Riggs BL: Cancellous bone remodelling in type 1(postmenopausal) osteoporosis: quantitative assessment of rates of formation, resorption and bone loss at tissue and cellular levels. J Bone Min Res. 1990, 5: 311-319.

Meunier PJ, Sellami S, Briancon D, Edouard C: Histological heterogeneity of apparently idiopathic osteoporosis. In: Osteoporosis - Recent Advances in Pathogenesis and Treatment. Edited by Deluca HF, Frost HM, Jee WSS, Johnston CC, Parfitt AM. Baltimore: University Park Press;. 1990, 293-301.

Lips P: Epidemiology and predictors of fractures associated with osteoporosis. Am J Med. 1997, 103: 3S-11S.

Cooper C: The crippling consequences of fractures and their impact on quality of life. Am J Med. 1997, 103: 12S-19S.

Gennari C, Nuti R: Bone loss in men. Calcified Tiss Int . 1996, 58: 1-3.

Kanis JA, Delmas P, Burckhardt P, Cooper C, Torgerson D: Guidelines for the diagnosis and management of osteoporosis. Osteoporosis Int. 1997, 7: 390-406.