Bone Marrow Stromal Cells Generate Muscle Cells and Repair Muscle Degeneration

American Association for the Advancement of Science (AAAS) - Tập 309 Số 5732 - Trang 314-317 - 2005
Mari Dezawa1,2,3, Hiroto Ishikawa1,2,3, Yutaka Itokazu1,2,3, Tomoyuki Yoshihara1,2,3, Mikio Hoshino1,2,3, Shin-ichi Takeda1,2,3, Chizuka Idé1,2,3, Yo-ichi Nabeshima1,2,3
1Department of Anatomy and Neurobiology, Kyoto University Graduate School of Medicine, Yoshidakonoecho, Sakyo-ku, Kyoto, 606-8501 Japan.
2Department of Molecular Therapy, National Center of Neurology and Psychiatry, Kodaira, 187-8502 Tokyo, Japan.
3Department of Pathology and Tumor Biology, Kyoto University Graduate School of Medicine, Yoshidakonoecho, Sakyo-ku, Kyoto, 606-8501 Japan.

Tóm tắt

Bone marrow stromal cells (MSCs) have great potential as therapeutic agents. We report a method for inducing skeletal muscle lineage cells from human and rat general adherent MSCs with an efficiency of 89%. Induced cells differentiated into muscle fibers upon transplantation into degenerated muscles of rats and mdx-nude mice. The induced population contained Pax7-positive cells that contributed to subsequent regeneration of muscle upon repetitive damage without additional transplantation of cells. These MSCs represent a more ready supply of myogenic cells than do the rare myogenic stem cells normally found in muscle and bone marrow.

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Tài liệu tham khảo

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We are grateful to N. Hashimoto and T. Partridge for providing the mdx-nude mice R. Kageyama for pCI-neo Hes6 R. Yu and M. M. Taketo for critical reading of the manuscript and M. Yoshida for technical assistance. This work was supported by Health and Labor Sciences Research Grants for “Research on Psychiatric and Neurological Diseases and Mental Health” and The Research Grant (16-B) for Nervous and Mental Disorders both from the Ministry of Health Labor and Welfare.

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American Association for the Advancement of Science (AAAS)

Tập 309 Số 5732

314-317

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