Body mass index, not dyslipidemia, is an independent predictor of survival in amyotrophic lateral sclerosis

Muscle and Nerve - Tập 44 Số 1 - Trang 20-24 - 2011
Sabrina Paganoni1, Jing Deng2, Matthew Jaffa2, Merit Cudkowicz2, Anne‐Marie Wills2
1Spaulding Rehabilitation Hospital, Harvard Medical School, Boston, Massachusetts, USA
2Neurology Clinical Trials Unit, Massachusetts General Hospital, Harvard Medical School, Charlestown Navy Yard, 149 13th Street, Charlestown, Massachusetts 02129, USA

Tóm tắt

AbstractIntroduction: Recent studies have provided conflicting data regarding the role of dyslipidemia in amyotrophic lateral sclerosis (ALS). The aim of this study was to determine whether cholesterol level are an independent predictor of survival in ALS. Methods: Cholesterol levels were measured in 427 ALS subjects from three clinical trial databases. Results: The LDL/HDL ratio did not decrease over time, despite significant declines in body mass index (BMI), forced vital capacity (FVC), and ALSFRS‐R. After adjusting for BMI, FVC, and age, the lipid ratio was not associated with survival. There was a “U”‐shaped association between BMI and mortality, with the highest survival at 30–35 kg/m2. The adjusted hazard ratio for the linear association between BMI and survival was 0.860 (95% CI 0.80–0.93, P = 0.0001). Conclusions: We found that dyslipidemia is not an independent predictor of survival in ALS. BMI is an independent prognostic factor for survival after adjusting for markers of disease severity. Muscle Nerve, 2011

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Muscle and Nerve

Tập 44 Số 1

20-24

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