Body mass index, circulating levels of sex-steroid hormones, IGF-I and IGF-binding protein-3: a cross-sectional study in healthy women

European Journal of Endocrinology - Trang 161-171 - 2004
Anne Zeleniuch‐Jacquotte1,2, Eva Lundin3, Paola Muti4, Anthony J. Mure5,2, Sabina Rinaldi2, Laure Dossus2, Andrea Micheli6, Alan A. Arslan7,8, Per Lenner9, Roy E. Shore4, Vittorio Krogh6, KL Koenig4, Elio Ríboli2, Franco Berrino6, G. Hallmans1, Kim Overvad10,2, Paolo Toniolo7,8, Sabina Sieri2
1Department of Public Health and Clinical Medicine, Nutritional Research, Umeå University Hospital, Umeå, Sweden
2International Agency for Research on Cancer, Lyon, France
3Department of Medical Biosciences/Pathology, University of Umeå, Umeå, Sweden
4Department of Social and Preventive Medicine, State University of New York at Buffalo, School of Medicine and Biomedical Sciences, Buffalo, New York, USA
5Ecole National Superieure Agronomique de Toulouse, Toulouse, France
6Unit of Epidemiology, Istituto Nazionale per lo Studioe la Cura dei Tumori, Milan, Italy
7Department of Environmental Medicine, New York University School of Medicine, New York, USA
8Department of Obstetrics and Gynecology, New York University School of Medicine, New York, NY10016, USA
9Department of Oncology, Umeå University Hospital, Umeå, Sweden
10Department of Urology and Andrology, Umeå University Hospital, Umeå, Sweden

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OBJECTIVE: Excess weight has been associated with increased risk of cancer at several organ sites. In part, this effect may be modulated through alterations in the metabolism of sex steroids and IGF-I related peptides. The objectives of the study were to examine the association of body mass index (BMI) with circulating androgens (testosterone, androstenedione and dehydroepiandrosterone sulfate (DHEAS)), estrogens (estrone and estradiol), sex hormone-binding globulin (SHBG), IGF-I and IGF-binding protein (IGFBP)-3, and the relationship between sex steroids, IGF-I and IGFBP-3. DESIGN AND METHODS: A cross-sectional analysis was performed using hormonal and questionnaire data of 620 healthy women (177 pre- and 443 post-menopausal). The laboratory measurements of the hormones of interest were available from two previous case-control studies on endogenous hormones and cancer risk. RESULTS: In the pre-menopausal group, BMI was not related to androgens and IGF-I. In the post-menopausal group, estrogens, testosterone and androstenedione increased with increasing BMI. The association with IGF-I was non-linear, with the highest mean concentrations observed in women with BMI between 24 and 25. In both pre- and post-menopausal subjects, IGFBP-3 did not vary across BMI categories and SHBG decreased with increasing BMI. As for the correlations between peptide and steroid hormones, in the post-menopausal group, IGF-I was positively related to androgens, inversely correlated with SHBG, and not correlated with estrogens. In the pre-menopausal group, similar but weaker correlations between IGF-I and androgens were observed. CONCLUSIONS: These observations offer evidence that obesity may influence the levels of endogenous sex-steroid and IGF-related hormones in the circulation, especially after menopause. Circulating IGF-I, androgens and SHBG appear to be related to each other in post-menopausal women.

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European Journal of Endocrinology

161-171

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