Body Fat Distribution Is a Determinant of the High-Density Lipoprotein Response to Dietary Fat and Cholesterol in Women

Arteriosclerosis, Thrombosis, and Vascular Biology - Tập 15 Số 8 - Trang 1070-1078 - 1995
Peter Clifton1, Mavis Abbey2, M. Noakes3, Sandra Beltrame4, Nicole Rumbelow5, Paul J. Nestel6
1Peter M. Clifton From CSIRO, Division of Human Nutrition, Adelaide, South Australia.
2Mavis Abbey From CSIRO, Division of Human Nutrition, Adelaide, South Australia.
3Mannie Noakes From CSIRO, Division of Human Nutrition, Adelaide, South Australia.
4Sandra Beltrame From CSIRO, Division of Human Nutrition, Adelaide, South Australia.
5Nicole Rumbelow From CSIRO, Division of Human Nutrition, Adelaide, South Australia.
6Paul J. Nestel From CSIRO, Division of Human Nutrition, Adelaide, South Australia.

Tóm tắt

AbstractWe have conducted a dietary trial that addressed the factors influencing the variability in plasma lipids in response to dietary fat and cholesterol with a focus on the effects of gender and body fat distribution. Sixty-seven women and 53 men were selected so that overall men and women had a similar mean age, LDL cholesterol, and body mass index. After a 2-week low-fat period subjects were given two liquid supplements for 3 weeks each, one that contained 31 to 40 g fat and 650 to 845 mg cholesterol, and one that was fat free. Measurements included plasma lipids and lipoproteins, glucose, insulin, hepatic triglyceride lipase activity, apolipoprotein E polymorphism, and three indexes of body fat (body mass index, waist girth, and waist-hip ratio). In response to dietary fat and cholesterol supplementation only the changes in HDL cholesterol, especially in HDL2, differed between the sexes. Although on univariate analysis lipoprotein changes were predicted by baseline lipoprotein levels, body mass index, waist girth, waist-hip ratio, hepatic triglyceride lipase activity, and insulin, multiple regression showed only waist-hip ratio to predict changes in HDL2cholesterol in women and body mass index and baseline HDL2cholesterol in men. Changes in LDL were predicted by baseline LDL cholesterol in women and apolipoprotein E phenotype and age in men. These studies explain much of the variability that individuals show in lipoprotein changes, especially in the more desirable changes in cholesterol transport in HDL2, in response to eating saturated fat and cholesterol.

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Arteriosclerosis, Thrombosis, and Vascular Biology

Tập 15 Số 8

1070-1078

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