Blood lead levels and enzymatic biomarkers of environmental lead exposure in children in Córdoba, Argentina, after the ban of leaded gasoline
Tóm tắt
Lead (Pb) is a developmental neurotoxicant found in industrial activities, many of them already prohibited worldwide. This study aimed to evaluate current blood Pb (PbB) levels in children in Cordoba, Argentina, and to compare these with similar studies performed before Pb was banned in gasoline in 1996. We also sought to identify mechanistically relevant biomarkers by measuring δ-aminolevulinic acid dehydratase (δ-ALAD), superoxide dismutase (SOD), and catalase (CAT) activities. We finally aimed to determine whether sociodemographic characteristics are associated with Pb toxicity. Blood samples collected from 161 healthy children between September 2009 and February 2010 revealed mean PbB levels of 2.58 ± 0.30 µg/dl. Enzymatic δ-ALAD, CAT, and SOD activities showed no significant variations when plotted against PbB levels. Finally, children living in the suburbs have higher PbB levels than their city counterparts, while low socioeconomic status increased δ-ALAD inhibition compared with that of middle-income children. Overall, these results evidenced a substantial reduction in exposure to Pb in this pediatric population over a decade after Pb was restricted in gasoline and reveal the importance of pursuing novel biomarkers of toxicity along with the sociodemographic profile to complement Pb diagnosis.
Từ khóa
Tài liệu tham khảo
Godwin HA. Lead exposure and poisoning in children. UCLA, Institute of the Environment, Southern California Environmental Report Card, 2009.
Balparda JK, 2008, Revista CES Medicina, 22, 43
Disalvo L, 2009, Archivos Argentinos de Pediatría, 107, 300
Garcia SI, 2003, Salud Publica Mex, 45, S252
Barberis S, 2006, Acta Toxicológica Argentina, 14, 2
De Oto L, Messina V, Aguirre J, Evaluación de plomo en aire suelo sangre en recién nacido-embarazada (zona industrial). 9° Encuentro Nacional de Investigación Pediátrica. Sociedad Argentina de Pediatría. Ciudad de Santa Fe, Provincia de Santa Fe 2007: 72.
Martínez Riera N, Soria N, Feldman G, Riera N. Niveles de plombemia y otros marcadores en niños expuestos a una fundición de plomo en Lastenia, Tucumán Argentina. Retel 2003.
Hansen C, 1999, Medicina (B Aires), 59, 167
Centers for Disease Control and Prevention (CDC), 1991, Screening young children for lead poisoning: guidance for State and Local Public Health Officials
Centers for Disease Control and Prevention (CDC). CDC response to Advisory Committee on Childhood Lead Poisoning Prevention recommendations in “Low level lead exposure harms children: a renewed call for primary prevention.” [on line] Atlanta, GA: US Department of Health and Human Services, CDC; 2012. Available in: http://www.cdc.gov/nceh/lead/acclpp/cdc_response_lead_exposure_recs.pdf
Bechara EJ, 1996, Braz J Med Biol Res, 29, 841
Patrick L, 2006, Altern Med Rev, 11, 114
Hessel DW, 1968, Atomic Absorption News, 7, 55
Vives JL, 1997, Manual de Técnicas de laboratorio en hematología, 2
Berlin A, 1974, Z klin Chem klin Biochem, 12, 389
López CM, 2005, Acta Bioquimica Clinica Latinoamericana, 39, 453
Centers for Disease Control and Prevention (CDC), 2000, JAMA, 283, 1416
Abelsohn AR, 2010, Can Fam Physician, 56, 531
US Environmental Protection Agency (US EPA). Air trends report: lead, 2007.
US Environmental Protection Agency (US EPA), 2007, Pilot study of targeting elevated blood lead levels in children (draft final report)
Centers for Disease Control and Prevention (CDC), 2009, MMWR, 58, 55
US Environmental Protection Agency (US EPA). Lead exposure associated with renovation and remodeling activities: phase III. Wisconsin Childhood Blood Lead Study. Washington DC: U.S. EPA, 2000.
Von Schirnding YE, 1991, S Afr Med J, 79, 454
Agency for Toxic Substances and Disease Registry (ATSDR). Toxicological profile for lead. (Draft for Public Comment). Department of Health and Human Services, Public Health Service. Atlanta, GA: US 2005, p.204.
Butnaru E, 2004, Revista medico-chirurgicală a Societăţii de Medici şi Naturalişti din Iaşi, 108, 165
Patrick L., 2006, Alternative Med Rev, 11, 2
Kasperczyk S, 2004, Ann Agr Environ Med, 11, 291