Birth Order Effects on Nonverbal IQ Scores in Autism Multiplex Families

Journal of Autism and Developmental Disorders - Tập 31 - Trang 449-460 - 2001
Donna Spiker1, Linda J. Lotspeich1, Sue Dimiceli1, Peter Szatmari2, Richard M. Myers3, Neil Risch3
1Division of Child Psychiatry and Child Development, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford
2Department of Psychiatry, McMaster University Research Building, Chedoke-McMaster Hospitals, Hamilton, Canada
3Department of Genetics, Stanford University School of Medicine, Stanford

Tóm tắt

Lord (1992) published a brief report showing a trend for decreasing nonverbal IQ scores with increasing birth order in a sample of 16 autism multiplex families, and urged replication in a larger sample. In this report, analyses of nonverbal IQ scores for a sample of 144 autism multiplex families indicated that nonverbal IQ scores were significantly lower in secondborn compared with firstborn siblings with autism. This birth order effect was independent of gender as well as the age differences within sib pairs. No such birth order effects were found for social or communicative deficits as measured by the Autism Diagnostic Interview-Revised (ADI-R), but there was a modest tendency for increased scores for ritualistic behaviors for the firstborn sibs. Further, there were no gender differences on nonverbal IQ scores in this sample. Results are discussed in terms of implications for genetic studies of autism.

Tài liệu tham khảo

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