Biostimulating Gut Microbiome with Bilberry Anthocyanin Combo to Enhance Anti-PD-L1 Efficiency against Murine Colon Cancer

Borghaei, 2015, Nivolumab versus docetaxel in advanced nonsquamous non-small-cell lung cancer, N. Engl. J. Med., 373, 1627, 10.1056/NEJMoa1507643

Motzer, 2015, Nivolumab versus everolimus in advanced renal-cell carcinoma, N. Engl. J. Med., 373, 1803, 10.1056/NEJMoa1510665

Ribas, 2018, Cancer immunotherapy using checkpoint blockade, Science, 359, 1350, 10.1126/science.aar4060

Yang, 2007, Ipilimumab (anti-CTLA4 antibody) causes regression of metastatic renal cell cancer associated with enteritis and hypophysitis, J. Immunother., 30, 825, 10.1097/CJI.0b013e318156e47e

Gopalakrishnan, 2018, Gut microbiome modulates response to anti-PD-1 immunotherapy in melanoma patients, Science, 359, 97, 10.1126/science.aan4236

Matson, 2018, The commensal microbiome is associated with anti-PD-1 efficacy in metastatic melanoma patients, Science, 359, 104, 10.1126/science.aao3290

Routy, 2018, Gut microbiome influences efficacy of PD-1-based immunotherapy against epithelial tumors, Science, 359, 91, 10.1126/science.aan3706

Sivan, 2015, Commensal Bifidobacterium promotes antitumor immunity and facilitates anti-PD-L1 efficacy, Science, 350, 1084, 10.1126/science.aac4255

Vetizou, 2015, Anticancer immunotherapy by CTLA-4 blockade relies on the gut microbiota, Science, 350, 1079, 10.1126/science.aad1329

Helmink, 2019, The microbiome, cancer, and cancer therapy, Nat. Med., 25, 377, 10.1038/s41591-019-0377-7

Jobin, 2018, Precision medicine using microbiota, Science, 359, 32, 10.1126/science.aar2946

Faria, 2014, Interplay between anthocyanins and gut microbiota, J. Agric. Food Chem., 62, 6898, 10.1021/jf501808a

Igwe, 2019, A systematic literature review of the effect of anthocyanins on gut microbiota populations, J. Hum. Nutr. Diet, 32, 53, 10.1111/jhn.12582

2009, Chemical studies of anthocyanins: A review, Food Chem., 113, 859, 10.1016/j.foodchem.2008.09.001

Hidalgo, 2012, Metabolism of anthocyanins by human gut microflora and their influence on gut bacterial growth, J. Agric. Food Chem., 60, 3882, 10.1021/jf3002153

Li, 2019, Bilberry anthocyanin extract promotes intestinal barrier function and inhibits digestive enzyme activity by regulating the gut microbiota in aging rats, Food Funct., 10, 333, 10.1039/C8FO01962B

Pan, 2017, Black raspberries and their anthocyanin and fiber fractions alter the composition and diversity of gut microbiota in F-344 rats, Nutr. Cancer, 69, 943, 10.1080/01635581.2017.1340491

Garcia-Mazcorro, J.F., Lage, N.N., Mertens-Talcott, S., Talcott, S., Chew, B., Dowd, S.E., Kawas, J.R., and Noratto, G.D. (2018). Effect of dark sweet cherry powder consumption on the gut microbiota, short-chain fatty acids, and biomarkers of gut health in obese db/db mice. PeerJ, 6.

McDougall, 2014, Tracking (poly)phenol components from raspberries in ileal fluid, J. Agric. Food Chem., 62, 7631, 10.1021/jf502259j

Stalmach, 2012, Gastrointestinal stability and bioavailability of (poly)phenolic compounds following ingestion of Concord grape juice by humans, Mol. Nutr. Food Res., 56, 497, 10.1002/mnfr.201100566

Seklemova, 2001, Biostimulation-based bioremediation of diesel fuel: Field demonstration, Biodegradation, 12, 311, 10.1023/A:1014356223118

Dong, 2015, Kinetic and multidimensional profiling of accelerated degradation of oil sludge by biostimulation, Env. Sci. Process. Impacts, 17, 763, 10.1039/C4EM00428K

Bindels, 2015, Towards a more comprehensive concept for prebiotics, Nat. Rev. Gastroenterol. Hepatol., 12, 303, 10.1038/nrgastro.2015.47

Kachrimanidou, 2018, In vitro fermentation properties of pectins and enzymatic-modified pectins obtained from different renewable bioresources, Carbohydr. Polym., 199, 482, 10.1016/j.carbpol.2018.07.041

Barnes, 2009, General method for extraction of blueberry anthocyanins and identification using high performance liquid chromatography-electrospray ionization-ion trap-time of flight-mass spectrometry, J. Chromatogr. A, 1216, 4728, 10.1016/j.chroma.2009.04.032

McDonald, 2014, Stability and biological activity of wild blueberry (Vaccinium angustifolium) polyphenols during simulated in vitro gastrointestinal digestion, Food Chem., 165, 522, 10.1016/j.foodchem.2014.05.135

AOAC (2005). Total monomeric anthocyanin pigment content of fruit juices, beverages, natural colorants and wine. J. AOAC Int., 88.

Langille, 2013, Predictive functional profiling of microbial communities using 16S rRNA marker gene sequences, Nat. Biotechnol., 31, 814, 10.1038/nbt.2676

Cassinese, 2007, New liquid chromatography method with ultraviolet detection for analysis of anthocyanins and anthocyanidins in Vaccinium myrtillus fruit dry extracts and commercial preparations, J. AOAC Int., 90, 911, 10.1093/jaoac/90.4.911

Derosa, 2018, Negative association of antibiotics on clinical activity of immune checkpoint inhibitors in patients with advanced renal cell and non-small-cell lung cancer, Ann. Oncol., 29, 1437, 10.1093/annonc/mdy103

Jin, 2019, The diversity of gut microbiome is associated with favorable responses to anti–programmed death 1 immunotherapy in Chinese patients with NSCLC, J. Thorac. Oncol., 14, 1378, 10.1016/j.jtho.2019.04.007

Vaiserman, 2017, Gut microbiota: A player in aging and a target for anti-aging intervention, Ageing Res. Rev., 35, 36, 10.1016/j.arr.2017.01.001

Koropatkin, 2012, How glycan metabolism shapes the human gut microbiota, Nat. Rev. Microbiol., 10, 323, 10.1038/nrmicro2746

Cockburn, 2016, Polysaccharide degradation by the intestinal microbiota and its influence on human health and disease, J. Mol. Biol., 428, 3230, 10.1016/j.jmb.2016.06.021

Louis, 2017, Formation of propionate and butyrate by the human colonic microbiota, Environ. Microbiol., 19, 29, 10.1111/1462-2920.13589

Cortellini, A., Bersanelli, M., Buti, S., Cannita, K., Santini, D., Perrone, F., Giusti, R., Tiseo, M., Michiara, M., and Di Marino, P. (2019). A multicenter study of body mass index in cancer patients treated with anti-PD-1/PD-L1 immune checkpoint inhibitors: When overweight becomes favorable. J. Immunother. Cancer, 7.

Xu, H., Cao, D., He, A., and Ge, W. (2019). The prognostic role of obesity is independent of sex in cancer patients treated with immune checkpoint inhibitors: A pooled analysis of 4090 cancer patients. Int. Immunopharmacol., 74.

Ichihara, 2020, The impact of body mass index on the efficacy of anti-PD-1/PD-L1 antibodies in patients with non-small cell lung cancer, Lung Cancer, 139, 140, 10.1016/j.lungcan.2019.11.011

Kichenadasse, G., Miners, J.O., Mangoni, A.A., Rowland, A., Hopkins, A.M., and Sorich, M.J. (2019). Association between body mass index and overall survival with immune checkpoint inhibitor therapy for advanced non–small cell lung cancer. JAMA Oncol.

Ley, R.E., Turnbaugh, P.J., Klein, S., and Gordon, J.I. (2006). Microbial ecology: Human gut microbes associated with obesity. Nature, 444.

Cani, P.D., Van Hul, M., Lefort, C., Depommier, C., Rastelli, M., and Everard, A. (2019). Microbial regulation of organismal energy homeostasis. Nat. Metab., 1.

Lee, Y.-M., Yoon, Y., Yoon, H., Park, H.-M., Song, S., and Yeum, K.-J. (2017). Dietary anthocyanins against obesity and inflammation. Nutrients, 9.

Overall, J., Bonney, S., Wilson, M., Beermann, A., Grace, M., Esposito, D., Lila, M., and Komarnytsky, S. (2017). Metabolic effects of berries with structurally diverse anthocyanins. Int. J. Mol. Sci., 18.

Meehan, 2014, A phylogenomic view of ecological specialization in the Lachnospiraceae, a family of digestive tract-associated bacteria, Genome Biol. Evol., 6, 703, 10.1093/gbe/evu050

Reichardt, 2018, Specific substrate-driven changes in human faecal microbiota composition contrast with functional redundancy in short-chain fatty acid production, ISME J., 12, 610, 10.1038/ismej.2017.196

Homicsko, K., Richtig, G., Tuchmann, F., Tsourti, Z., Hanahan, D., Coukos, G., Wind-Rotolo, M., Richtig, E., Zygoura, P., and Holler, C. (2018). Proton pump inhibitors negatively impact survival of PD-1 inhibitor based therapies in metastatic melanoma patients. Ann. Oncol., 29.

Trabolsi, A., Winter, M., and Rodriguez, E. (2019). Proton pump inhibitors and response to immune check-point inhibitors: Single center study. Am. Soc. Clin. Oncol., 37.

Mukherjee, 2019, Do proton pump inhibitors modulate the efficacy of anti-PD-1/PD-L1 therapy? A retrospective study, J. Oncol. Pharm. Pract., 25, 762, 10.1177/1078155218771152

Kim, H., Lee, J.E., Hong, S.H., Lee, M.A., Kang, J.H., and Kim, I.-H. (2019). The effect of antibiotics on the clinical outcomes of patients with solid cancers undergoing immune checkpoint inhibitor treatment: A retrospective study. BMC Cancer, 19.