Biological and Analytical Stability of a Peripheral Blood Gene Expression Score for Obstructive Coronary Artery Disease in the PREDICT and COMPASS Studies

Patel, M. R., Peterson, E. D., Dai, D., Brennan, J. M., Redberg, R. F., Anderson, H. V., Brindis, R. G., & Douglas, P. S. (2010). Low diagnostic yield of elective coronary angiography. The New England Journal of Medicine, 362, 886–895.

Rozanski, A., Gransar, H., Hayes, S. W., Min, J., Friedman, J. D., Thomson, L. E., & Berman, D. S. (2013). Temporal trends in the frequency of inducible myocardial ischemia during cardiac stress testing: 1991 to 2009. Journal of the American College of Cardiology, 61, 1054–1065.

Libby, P., Ridker, P. M., & Maseri, A. (2002). Inflammation and atherosclerosis. Circulation, 105, 1135–1143.

Ross, R. (1999). Atherosclerosis–an inflammatory disease. The New England Journal of Medicine, 340, 115–126.

Wingrove, J. A., Daniels, S. E., Sehnert, A. J., Tingley, W., Elashoff, M. R., Rosenberg, S., Buellesfeld, L., Grube, E., Newby, L. K., Ginsburg, G. S., & Kraus, W. E. (2008). Correlation of peripheral-blood gene expression with the extent of coronary artery stenosis. Circulation. Cardiovascular Genetics, 1, 31–38.

Elashoff, M. R., Wingrove, J. A., Beineke, P., Daniels, S. E., Tingley, W. G., Rosenberg, S., Voros, S., Kraus, W. E., Ginsburg, G. S., Schwartz, R. S., Ellis, S. G., Tahirkheli, N., Waksman, R., McPherson, J., Lansky, A. J., & Topol, E. J. (2011). Development of a blood-based gene expression algorithm for assessment of obstructive coronary artery disease in non-diabetic patients. BMC Medical Genomics, 4, 26.

Rosenberg, S., Elashoff, M. R., Beineke, P., Daniels, S. E., Wingrove, J. A., Tingley, W. G., Sager, P. T., Sehnert, A. J., Yau, M., Kraus, W. E., Newby, L. K., Schwartz, R. S., Voros, S., Ellis, S. G., Tahirkheli, N., Waksman, R., McPherson, J., Lansky, A., Winn, M. E., Schork, N. J., & Topol, E. J. (2010). Multicenter validation of the diagnostic accuracy of a blood-based gene expression test for assessing obstructive coronary artery disease in nondiabetic patients. Annals of Internal Medicine, 153, 425–434.

Thomas, G. S., Voros, S., McPherson, J. A., Lansky, A. J., Winn, M. E., Bateman, T. M., Elashoff, M. R., Lieu, H. D., Johnson, A. M., Daniels, S. E., Ladapo, J. A., Phelps, C. E., Douglas, P. S., & Rosenberg, S. (2013). A blood-based gene expression test for obstructive coronary artery disease tested in symptomatic nondiabetic patients referred for myocardial perfusion imaging the compass study. Circulation. Cardiovascular Genetics, 6, 154–162.

Rosenberg, S., Elashoff, M. R., Lieu, H. D., Brown, B. O., Kraus, W. E., Schwartz, R. S., Voros, S., Ellis, S. G., Waksman, R., McPherson, J. A., Lansky, A. J., & Topol, E. J. (2012). Whole blood gene expression testing for coronary artery disease in nondiabetic patients: major adverse cardiovascular events and interventions in the predict trial. Journal of Cardiovascular Translational Research, 2012, 7.

Vargas, J., Lima, J.A., Kraus, W.E., Douglas, P.S., & Rosenberg, S. (2013). Use of the Corus® cad gene expression test for assessment of obstructive coronary artery disease likelihood in symptomatic non-diabetic patients. PLoS Currents, 5.

Zeller, T., & Blankenberg, S. (2013). Blood-based gene expression tests: promises and limitations. Circulation. Cardiovascular Genetics, 6, 139–140.

Vargas, J. D., & Lima, J. A. (2013). Coronary artery disease: a gene-expression score to predict obstructive CAD. Nature Reviews Cardiology, 10, 43–244.

Lansky, A. J., & Popma, J. J. (1998). Qualitative and quantitative angiography. Philadelphia, PA: Saunders.

Voros, S., Elashoff, M. R., Wingrove, J. A., Budoff, M. J., Thomas, G. S., & Rosenberg, S. (2014). A peripheral blood gene expression score is associated with atherosclerotic plaque burden and stenosis by cardiovascular CT-angiography: results from the PREDICT and COMPASS studies. Atherosclerosis, 233, 284–290.

Elashoff, M. R., Nuttall, R., Beineke, P., Doctolero, M. H., Dickson, M., Johnson, A. M., Daniels, S. E., Rosenberg, S., & Wingrove, J. A. (2012). Identification of factors contributing to variability in a blood-based gene expression test. PLoS One, 7, e40068.

RDC T (2007). R: a language and environment for statistical computing. Vienna, Austria: R foundation for statistical computing.

Nallamothu, B. K., Spertus, J. A., Lansky, A. J., Cohen, D. J., Jones, P. G., Kureshi, F., Dehmer, G. J., Drozda, J. P., Jr., Walsh, M. N., Brush, J. E., Jr., Koenig, G. C., Waites, T. F., Gantt, D. S., Kichura, G., Chazal, R. A., O’Brien, P. K., Valentine, C. M., Rumsfeld, J. S., Reiber, J. H., Elmore, J. G., Krumholz, R. A., Weaver, W. D., & Krumholz, H. M. (2013). Comparison of clinical interpretation with visual assessment and quantitative coronary angiography in patients undergoing percutaneous coronary intervention in contemporary practice: the assessing angiography (A2) project. Circulation, 127, 1793–1800.

Debey-Pascher, S., Hofmann, A., Kreusch, F., Schuler, G., Schuler-Thurner, B., Schultze, J. L., & Staratschek-Jox, A. (2011). RNA-stabilized whole blood samples but not peripheral blood mononuclear cells can be stored for prolonged time periods prior to transcriptome analysis. The Journal of Molecular Diagnostics, 13, 452–460.

Huang, C. C., Lloyd-Jones, D. M., Guo, X., Rajamannan, N. M., Lin, S. M., Du, P., Huang, Q., Hou, L., & Liu, K. (2011). Gene expression variation between African Americans and Whites is associated with coronary artery calcification: the multi-ethnic study of atherosclerosis. Physiological Genomics, 2011, 26.

Papadopoulou, S. L., Neefjes, L. A., Garcia-Garcia, H. M., Flu, W. J., Rossi, A., Dharampal, A. S., Kitslaar, P. H., Mollet, N. R., Veldhof, S., Nieman, K., Stone, G. W., Serruys, P. W., Krestin, G. P., & de Feyter, P. J. (2012). Natural history of coronary atherosclerosis by multislice computed tomography. JACC. Cardiovascular Imaging, 5, S28–37.

Zeb, I., Li, D., Nasir, K., Malpeso, J., Batool, A., Flores, F., Dailing, C., Karlsberg, R. P., & Budoff, M. (2013). Effect of statin treatment on coronary plaque progression - a serial coronary CT angiography study. Atherosclerosis, 231, 198–204.

Ellsworth, D. L., Croft, D. T., Jr., Weyandt, J., Sturtz, L. A., Blackburn, H. L., Burke, A., Haberkorn, M. J., McDyer, F. A., Jellema, G. L., van Laar, R., Mamula, K. A., Chen, Y., & Vernalis, M. N. (2014). Intensive cardiovascular risk reduction induces sustainable changes in expression of genes and pathways important to vascular function. Circulation. Cardiovascular Genetics, 7, 151–160.

Lansky, A., Elashoff, M. R., Ng, V., McPherson, J., Lazar, D., Kraus, W. E., Voros, S., Schwartz, R. S., & Topol, E. J. (2012). A gender-specific blood-based gene expression score for assessing obstructive coronary artery disease in nondiabetic patients: results of the Personalized Risk Evaluation and Diagnosis in the Coronary Tree (PREDICT) trial. American Heart Journal, 164, 320–326.

Sinicropi, D., Qu, K., Collin, F., Crager, M., Liu, M. L., Pelham, R. J., Pho, M., Dei Rossi, A., Jeong, J., Scott, A., Ambannavar, R., Zheng, C., Mena, R., Esteban, J., Stephans, J., Morlan, J., & Baker, J. (2012). Whole transcriptome RNA-seq analysis of breast cancer recurrence risk using formalin-fixed paraffin-embedded tumor tissue. PLoS One, 7, e40092.