Biological Toxicity of the Compositions in Electronic-Cigarette on Cardiovascular System

CDC. (2014). The Health Consequences of Smoking-50 Years of Progress: A Report of the Surgeon General. Reports of the Surgeon General. Atlanta (GA).

Cullen, K. A., Ambrose, B. K., Gentzke, A. S., Apelberg, B. J., Jamal, A., & King, B. A. (2018). Notes from the Field: Use of Electronic Cigarettes and Any Tobacco Product Among Middle and High School Students - United States, 2011–2018. MMWR Morb Mortal Wkly Rep, 67(45), 1276–1277. https://doi.org/10.15585/mmwr.mm6745a5.

CDC. (2016). E-Cigarette Use Among Youth and Young Adults: A Report of the Surgeon General. Publications and Reports of the Surgeon General. Atlanta (GA).

McNeill, A. B. L., Calder, R., Hitchman, S. C., Hajek, P., & McRobbie, H. (2015). E-cigarettes: an evidence update. A report commissioned by Public Health England. UK Centre for Tobacco & Alcohol Studies.

Benowitz, N. L., & Burbank, A. D. (2016). Cardiovascular toxicity of nicotine: implications for electronic cigarette use. Trends in Cardiovascular Medicine, 26(6), 515–523. https://doi.org/10.1016/j.tcm.2016.03.001.

Buchanan, N. D., Grimmer, J. A., Tanwar, V., Schwieterman, N., Mohler, P. J., & Wold, L. E. (2020). Cardiovascular risk of electronic cigarettes: a review of preclinical and clinical studies. Cardiovascular Research, 116(1), 40–50. https://doi.org/10.1093/cvr/cvz256.

Colombo, E. S., Davis, J., Makvandi, M., Aragon, M., Lucas, S. N., Paffett, M. L., et al. (2013). Effects of nicotine on cardiovascular remodeling in a mouse model of systemic hypertension. Cardiovascular Toxicology, 13(4), 364–369. https://doi.org/10.1007/s12012-013-9217-z.

Joseph, A. M., Norman, S. M., Ferry, L. H., Prochazka, A. V., Westman, E. C., Steele, B. G., et al. (1996). The safety of transdermal nicotine as an aid to smoking cessation in patients with cardiac disease. The New England Journal of Medicine, 335(24), 1792–1798. https://doi.org/10.1056/NEJM199612123352402.

Mills, E. J., Thorlund, K., Eapen, S., Wu, P., & Prochaska, J. J. (2014). Cardiovascular events associated with smoking cessation pharmacotherapies: a network meta-analysis. Circulation., 129(1), 28–41. https://doi.org/10.1161/CIRCULATIONAHA.113.003961.

Hiler, M., Breland, A., Spindle, T., Maloney, S., Lipato, T., Karaoghlanian, N., et al. (2017). Electronic cigarette user plasma nicotine concentration, puff topography, heart rate, and subjective effects: Influence of liquid nicotine concentration and user experience. Experimental and Clinical Psychopharmacology, 25(5), 380–392. https://doi.org/10.1037/pha0000140.

Shields, P. G., Berman, M., Brasky, T. M., Freudenheim, J. L., Mathe, E., McElroy, J. P., et al. (2017). A review of pulmonary toxicity of electronic cigarettes in the context of smoking: a focus on inflammation. Cancer Epidemiology, Biomarkers & Prevention, 26(8), 1175–1191. https://doi.org/10.1158/1055-9965.EPI-17-0358.

Grana, R., Benowitz, N., & Glantz, S. A. (2014). E-cigarettes: a scientific review. Circulation., 129(19), 1972–1986. https://doi.org/10.1161/CIRCULATIONAHA.114.007667.

Kosmider, L., Sobczak, A., Fik, M., Knysak, J., Zaciera, M., Kurek, J., et al. (2014). Carbonyl compounds in electronic cigarette vapors: effects of nicotine solvent and battery output voltage. Nicotine & Tobacco Research, 16(10), 1319–1326. https://doi.org/10.1093/ntr/ntu078.

Sleiman, M., Logue, J. M., Montesinos, V. N., Russell, M. L., Litter, M. I., Gundel, L. A., et al. (2016). Emissions from electronic cigarettes: key parameters affecting the release of harmful chemicals. Environmental Science & Technology, 50(17), 9644–9651. https://doi.org/10.1021/acs.est.6b01741.

Gillman, I. G., Kistler, K. A., Stewart, E. W., & Paolantonio, A. R. (2016). Effect of variable power levels on the yield of total aerosol mass and formation of aldehydes in e-cigarette aerosols. Regulatory Toxicology and Pharmacology, 75, 58–65. https://doi.org/10.1016/j.yrtph.2015.12.019.

Benowitz, N. L., & Fraiman, J. B. (2017). Cardiovascular effects of electronic cigarettes. Nature Reviews. Cardiology, 14(8), 447–456. https://doi.org/10.1038/nrcardio.2017.36.

Muthumalage, T., Prinz, M., Ansah, K. O., Gerloff, J., Sundar, I. K., & Rahman, I. (2017). Inflammatory and oxidative responses induced by exposure to commonly used e-cigarette flavoring chemicals and flavored e-liquids without nicotine. Frontiers in Physiology, 8, 1130. https://doi.org/10.3389/fphys.2017.01130.

Madison, M. C., Landers, C. T., Gu, B. H., Chang, C. Y., Tung, H. Y., You, R., et al. (2019). Electronic cigarettes disrupt lung lipid homeostasis and innate immunity independent of nicotine. The Journal of Clinical Investigation, 129(10), 4290–4304. https://doi.org/10.1172/JCI128531.

Fetterman, J. L., Weisbrod, R. M., Feng, B., Bastin, R., Tuttle, S. T., Holbrook, M., et al. (2018). Flavorings in tobacco products induce endothelial cell dysfunction. Arteriosclerosis, thrombosis, and vascular biology., 38(7), 1607–1615. https://doi.org/10.1161/ATVBAHA.118.311156.

D'Amario, D., Migliaro, S., Borovac, J. A., Vergallo, R., Galli, M., Restivo, A., et al. (2019). Electronic Cigarettes and Cardiovascular Risk: Caution Waiting for Evidence. Eur Cardiol., 14(3), 151–158. https://doi.org/10.15420/ecr.2019.16.2.

Szoltysek-Boldys, I., Sobczak, A., Zielinska-Danch, W., Barton, A., Koszowski, B., & Kosmider, L. (2014). Influence of inhaled nicotine source on arterial stiffness. Przegl Lek., 71(11), 572–575 https://www.ncbi.nlm.nih.gov/pubmed/25799846.

Farsalinos, K., Cibella, F., Caponnetto, P., Campagna, D., Morjaria, J. B., Battaglia, E., et al. (2016). Effect of continuous smoking reduction and abstinence on blood pressure and heart rate in smokers switching to electronic cigarettes. Internal and Emergency Medicine, 11(1), 85–94. https://doi.org/10.1007/s11739-015-1361-y.

Farsalinos, K. E., Tsiapras, D., Kyrzopoulos, S., Savvopoulou, M., & Voudris, V. (2014). Acute effects of using an electronic nicotine-delivery device (electronic cigarette) on myocardial function: comparison with the effects of regular cigarettes. BMC Cardiovascular Disorders, 14, 78. https://doi.org/10.1186/1471-2261-14-78.

Vlachopoulos, C., Ioakeimidis, N., Abdelrasoul, M., Terentes-Printzios, D., Georgakopoulos, C., Pietri, P., et al. (2016). Electronic cigarette smoking increases aortic stiffness and blood pressure in young smokers. Journal of the American College of Cardiology, 67(23), 2802–2803. https://doi.org/10.1016/j.jacc.2016.03.569.

Moheimani, R. S., Bhetraratana, M., Yin, F., Peters, K. M., Gornbein, J., Araujo, J. A., et al. (2017). Increased cardiac sympathetic activity and oxidative stress in habitual electronic cigarette users: implications for cardiovascular risk. JAMA Cardiology, 2(3), 278–284. https://doi.org/10.1001/jamacardio.2016.5303.

Alzahrani, T., Pena, I., Temesgen, N., & Glantz, S. A. (2018). Association between electronic cigarette use and myocardial infarction. American Journal of Preventive Medicine, 55(4), 455–461. https://doi.org/10.1016/j.amepre.2018.05.004.

Olfert, I. M., DeVallance, E., Hoskinson, H., Branyan, K. W., Clayton, S., Pitzer, C. R., et al. (2018). Chronic exposure to electronic cigarettes results in impaired cardiovascular function in mice. J Appl Physiol (1985), 124(3), 573–582. https://doi.org/10.1152/japplphysiol.00713.2017.

Crotty Alexander, L. E., Drummond, C. A., Hepokoski, M., Mathew, D., Moshensky, A., Willeford, A., et al. (2018). Chronic inhalation of e-cigarette vapor containing nicotine disrupts airway barrier function and induces systemic inflammation and multiorgan fibrosis in mice. American Journal of Physiology, Regulatory, Integrative and Comparative Physiology, 314(6), R834–RR47. https://doi.org/10.1152/ajpregu.00270.2017.

Takeshita, D., Nakajima-Takenaka, C., Shimizu, J., Hattori, H., Nakashima, T., Kikuta, A., et al. (2009). Effects of formaldehyde on cardiovascular system in in situ rat hearts. Basic & Clinical Pharmacology & Toxicology, 105(4), 271–280. https://doi.org/10.1111/j.1742-7843.2009.00442.x.

Perez, C. M., Hazari, M. S., Ledbetter, A. D., Haykal-Coates, N., Carll, A. P., Cascio, W. E., et al. (2015). Acrolein inhalation alters arterial blood gases and triggers carotid body-mediated cardiovascular responses in hypertensive rats. Inhalation Toxicology, 27(1), 54–63. https://doi.org/10.3109/08958378.2014.984881.

Hazari, M. S., Haykal-Coates, N., Winsett, D. W., Krantz, Q. T., King, C., Costa, D. L., et al. (2011). TRPA1 and sympathetic activation contribute to increased risk of triggered cardiac arrhythmias in hypertensive rats exposed to diesel exhaust. Environmental Health Perspectives, 119(7), 951–957. https://doi.org/10.1289/ehp.1003200.

Luo, J., Hill, B. G., Gu, Y., Cai, J., Srivastava, S., Bhatnagar, A., et al. (2007). Mechanisms of acrolein-induced myocardial dysfunction: implications for environmental and endogenous aldehyde exposure. American Journal of Physiology. Heart and Circulatory Physiology, 293(6), H3673–H3684. https://doi.org/10.1152/ajpheart.00284.2007.

Palpant, N. J., Hofsteen, P., Pabon, L., Reinecke, H., & Murry, C. E. (2015). Cardiac development in zebrafish and human embryonic stem cells is inhibited by exposure to tobacco cigarettes and e-cigarettes. PLoS One, 10(5), e0126259. https://doi.org/10.1371/journal.pone.0126259.

Lee, W. H., Ong, S. G., Zhou, Y., Tian, L., Bae, H. R., Baker, N., et al. (2019). Modeling cardiovascular risks of e-cigarettes with human-induced pluripotent stem cell-derived endothelial cells. Journal of the American College of Cardiology, 73(21), 2722–2737. https://doi.org/10.1016/j.jacc.2019.03.476.

Antoniewicz, L., Bosson, J. A., Kuhl, J., Abdel-Halim, S. M., Kiessling, A., Mobarrez, F., et al. (2016). Electronic cigarettes increase endothelial progenitor cells in the blood of healthy volunteers. Atherosclerosis., 255, 179–185. https://doi.org/10.1016/j.atherosclerosis.2016.09.064.

Farsalinos, K. E., Romagna, G., Allifranchini, E., Ripamonti, E., Bocchietto, E., Todeschi, S., et al. (2013). Comparison of the cytotoxic potential of cigarette smoke and electronic cigarette vapour extract on cultured myocardial cells. International Journal of Environmental Research and Public Health, 10(10), 5146–5162. https://doi.org/10.3390/ijerph10105146.

MacDonald, A., & Middlekauff, H. R. (2019). Electronic cigarettes and cardiovascular health: what do we know so far? Vascular Health and Risk Management, 15, 159–174. https://doi.org/10.2147/VHRM.S175970.

Carnevale, R., Sciarretta, S., Violi, F., Nocella, C., Loffredo, L., Perri, L., et al. (2016). Acute impact of tobacco vs electronic cigarette smoking on oxidative stress and vascular function. Chest., 150(3), 606–612. https://doi.org/10.1016/j.chest.2016.04.012.

Wong, N. D., Gransar, H., Narula, J., Shaw, L., Moon, J. H., Miranda-Peats, R., et al. (2009). Myeloperoxidase, subclinical atherosclerosis, and cardiovascular disease events. JACC: Cardiovascular Imaging, 2(9), 1093–1099. https://doi.org/10.1016/j.jcmg.2009.05.012.