Biogenesis of the multifunctional lipid droplet: Lipids, proteins, and sites
Tóm tắt
Từ khóa
Tài liệu tham khảo
Adeyo, 2011, The yeast lipin orthologue Pah1p is important for biogenesis of lipid droplets, J. Cell Biol., 192, 1043, 10.1083/jcb.201010111
Anand, 2012, A novel role for lipid droplets in the organismal antibacterial response, Elife., 1, e00003, 10.7554/eLife.00003
Andersson, 2006, PLD1 and ERK2 regulate cytosolic lipid droplet formation, J. Cell Sci., 119, 2246, 10.1242/jcs.02941
Athenstaedt, 1997, Biosynthesis of phosphatidic acid in lipid particles and endoplasmic reticulum of Saccharomyces cerevisiae, J. Bacteriol., 179, 7611, 10.1128/jb.179.24.7611-7616.1997
Ayciriex, 2012, YPR139c/LOA1 encodes a novel lysophosphatidic acid acyltransferase associated with lipid droplets and involved in TAG homeostasis, Mol. Biol. Cell., 23, 233, 10.1091/mbc.E11-07-0650
Bartz, 2007, Lipidomics reveals that adiposomes store ether lipids and mediate phospholipid traffic, J. Lipid Res., 48, 837, 10.1194/jlr.M600413-JLR200
Bi, 2012, Opposite and redundant roles of the two Drosophila perilipins in lipid mobilization, J. Cell Sci., 125, 3568, 10.1242/jcs.101329
Bickel, 2009, PAT proteins, an ancient family of lipid droplet proteins that regulate cellular lipid stores, Biochim. Biophys. Acta., 1791, 419, 10.1016/j.bbalip.2009.04.002
Blanchette-Mackie, 1995, Perilipin is located on the surface layer of intracellular lipid droplets in adipocytes, J. Lipid Res., 36, 1211, 10.1016/S0022-2275(20)41129-0
Borgese, 2007, How tails guide tail-anchored proteins to their destinations, Curr. Opin. Cell Biol., 19, 368, 10.1016/j.ceb.2007.04.019
Brasaemle, 2012, Packaging of fat: an evolving model of lipid droplet assembly and expansion, J. Biol. Chem., 287, 2273, 10.1074/jbc.R111.309088
Brasaemle, 2004, Proteomic analysis of proteins associated with lipid droplets of basal and lipolytically stimulated 3T3-L1 adipocytes, J. Biol. Chem., 279, 46835, 10.1074/jbc.M409340200
Bulankina, 2009, TIP47 functions in the biogenesis of lipid droplets, J. Cell Biol., 185, 641, 10.1083/jcb.200812042
Butler, 2010, Cross-talk between remodeling and de novo pathways maintains phospholipid balance through ubiquitination, J. Biol. Chem., 285, 6246, 10.1074/jbc.M109.017350
Cartwright, 2012, Seipin: from human disease to molecular mechanism, J. Lipid Res., 53, 1042, 10.1194/jlr.R023754
Chang, 2006, Protection against fatty liver but normal adipogenesis in mice lacking adipose differentiation-related protein, Mol. Cell. Biol., 26, 1063, 10.1128/MCB.26.3.1063-1076.2006
Chapman, 2012, Biogenesis and functions of lipid droplets in plants: Thematic review series: lipid droplet synthesis and metabolism: from yeast to man, J. Lipid Res., 53, 215, 10.1194/jlr.R021436
Chen, 2002, Oleic acid-induced PKC isozyme translocation in RAW 264.7 macrophages, J. Cell. Biochem., 86, 784, 10.1002/jcb.10266
Choudhary, 2011, The topology of the triacylglycerol synthesizing enzyme Lro1 indicates that neutral lipids can be produced within the luminal compartment of the endoplasmatic reticulum: Implications for the biogenesis of lipid droplets, Commun. Integr. Biol., 4, 781, 10.4161/cib.17830
Cornell, 2000, Regulation of CTP:phosphocholine cytidylyltransferase by amphitropism and relocalization, Trends Biochem. Sci., 25, 441, 10.1016/S0968-0004(00)01625-X
Cui, 2012, Overexpression of a short human seipin/BSCL2 isoform in mouse adipose tissue results in mild lipodystrophy, Am. J. Physiol. Endocrinol. Metab., 302, E705, 10.1152/ajpendo.00237.2011
Czabany, 2008, Structural and biochemical properties of lipid particles from the yeast Saccharomyces cerevisiae, J. Biol. Chem., 283, 17065, 10.1074/jbc.M800401200
Doege, 2006, Protein-mediated fatty acid uptake: novel insights from in vivo models, Physiology (Bethesda)., 21, 259, 10.1152/physiol.00014.2006
Du, 2009, Starving neurons show sex difference in autophagy, J. Biol. Chem., 284, 2383, 10.1074/jbc.M804396200
Eastman, 2009, A role for ubiquitin ligases and Spartin/SPG20 in lipid droplet turnover, J. Cell Biol., 184, 881, 10.1083/jcb.200808041
Ellis, 2010, Acyl-coenzyme A synthetases in metabolic control, Curr. Opin. Lipidol., 21, 212, 10.1097/MOL.0b013e32833884bb
Fei, 2008, Fld1p, a functional homologue of human seipin, regulates the size of lipid droplets in yeast, J. Cell Biol., 180, 473, 10.1083/jcb.200711136
Fei, 2011, Seipin, adipogenesis and lipid droplets, Trends Endocrinol. Metab., 22, 204, 10.1016/j.tem.2011.02.004
Fei, 2011, Molecular characterization of seipin and its mutants: implications for seipin in triacylglycerol synthesis, J. Lipid Res., 52, 2136, 10.1194/jlr.M017566
Fujimoto, 2011, Not just fat: the structure and function of the lipid droplet, Cold Spring Harb. Perspect. Biol., 3, a004838, 10.1101/cshperspect.a004838
Fujimoto, 2004, Identification of major proteins in the lipid droplet-enriched fraction isolated from the human hepatocyte cell line HuH7, Biochim. Biophys. Acta., 1644, 47, 10.1016/j.bbamcr.2003.10.018
Fujimoto, 2007, Involvement of ACSL in local synthesis of neutral lipids in cytoplasmic lipid droplets in human hepatocyte HuH7, J. Lipid Res., 48, 1280, 10.1194/jlr.M700050-JLR200
Füllekrug, 2012, Outlook: membrane junctions enable the metabolic trapping of fatty acids by intracellular acyl-CoA synthetases, Front Physiol., 3, 401, 10.3389/fphys.2012.00401
Fuller, 2001, The influence of lysolipids on the spontaneous curvature and bending elasticity of phospholipid membranes, Biophys. J., 81, 243, 10.1016/S0006-3495(01)75695-0
Garbarino, 2009, Sterol and diacylglycerol acyltransferase deficiency triggers fatty acid-mediated cell death, J. Biol. Chem., 284, 30994, 10.1074/jbc.M109.050443
Gorrissen, 1980, Deuterium magnetic resonance of selectively deuterated cholesteryl esters in phosphatidylcholine vesicles, Biochemistry., 19, 3422, 10.1021/bi00556a003
Gorrissen, 1982, Deuterium magnetic resonance of triacylglycerols in phospholipid bilayers, Chem. Phys. Lipids., 31, 245, 10.1016/0009-3084(82)90060-3
Gross, 2010, Structural insights into triglyceride storage mediated by fat storage-inducing transmembrane (FIT) protein 2, PLoS ONE., 5, e10796, 10.1371/journal.pone.0010796
Gross, 2011, Direct binding of triglyceride to fat storage-inducing transmembrane proteins 1 and 2 is important for lipid droplet formation, Proc. Natl. Acad. Sci. USA., 108, 19581, 10.1073/pnas.1110817108
Gubern, 2008, Group IVA phospholipase A2 is necessary for the biogenesis of lipid droplets, J. Biol. Chem., 283, 27369, 10.1074/jbc.M800696200
Ha, 2012, Regulation of the Golgi complex by phospholipid remodeling enzymes, Biochim. Biophys. Acta., 1821, 1078, 10.1016/j.bbalip.2012.04.004
Hapala, 2011, Is fat so bad? Modulation of endoplasmic reticulum stress by lipid droplet formation, Biol. Cell., 103, 271, 10.1042/BC20100144
Harris, 2011, DGAT enzymes are required for triacylglycerol synthesis and lipid droplets in adipocytes, J. Lipid Res., 52, 657, 10.1194/jlr.M013003
Herker, 2012, Emerging role of lipid droplets in host/pathogen interactions, J. Biol. Chem., 287, 2280, 10.1074/jbc.R111.300202
Herms, 2013, Cell-to-cell heterogeneity in lipid droplets suggests a mechanism to reduce lipotoxicity, Curr. Biol., 23, 1489, 10.1016/j.cub.2013.06.032
Hinson, 2009, The antiviral protein, viperin, localizes to lipid droplets via its N-terminal amphipathic alpha-helix, Proc. Natl. Acad. Sci. USA., 106, 20452, 10.1073/pnas.0911679106
Hörl, 2011, Sequential synthesis and methylation of phosphatidylethanolamine promote lipid droplet biosynthesis and stability in tissue culture and in vivo, J. Biol. Chem., 286, 17338, 10.1074/jbc.M111.234534
Igal, 1996, Acylglycerol recycling from triacylglycerol to phospholipid, not lipase activity, is defective in neutral lipid storage disease fibroblasts, J. Biol. Chem., 271, 16644, 10.1074/jbc.271.28.16644
Ingelmo-Torres, 2009, Hydrophobic and basic domains target proteins to lipid droplets, Traffic., 10, 1785, 10.1111/j.1600-0854.2009.00994.x
Jacquier, 2011, Lipid droplets are functionally connected to the endoplasmic reticulum in Saccharomyces cerevisiae, J. Cell Sci., 124, 2424, 10.1242/jcs.076836
Jacquier, 2013, Expression of oleosin and perilipins in yeast promotes formation of lipid droplets from the endoplasmic reticulum, J. Cell Sci., 126, 5198, 10.1242/jcs.131896
Jamil, 1990, Feedback regulation of CTP:phosphocholine cytidylyltransferase translocation between cytosol and endoplasmic reticulum by phosphatidylcholine, J. Biol. Chem., 265, 4332, 10.1016/S0021-9258(19)39568-7
Kadereit, 2008, Evolutionarily conserved gene family important for fat storage, Proc. Natl. Acad. Sci. USA., 105, 94, 10.1073/pnas.0708579105
Karanasios, 2010, A phosphorylation-regulated amphipathic helix controls the membrane translocation and function of the yeast phosphatidate phosphatase, Proc. Natl. Acad. Sci. USA., 107, 17539, 10.1073/pnas.1007974107
Karanasios, 2013, Regulation of lipid droplet and membrane biogenesis by the acidic tail of the phosphatidate phosphatase Pah1p, Mol. Biol. Cell., 24, 2124, 10.1091/mbc.E13-01-0021
Kassan, 2013, Acyl-CoA synthetase 3 promotes lipid droplet biogenesis in ER microdomains, J. Cell Biol., 203, 985, 10.1083/jcb.201305142
Khandelia, 2010, Triglyceride blisters in lipid bilayers: implications for lipid droplet biogenesis and the mobile lipid signal in cancer cell membranes, PLoS ONE., 5, e12811, 10.1371/journal.pone.0012811
Khelef, 1998, Immunolocalization of acyl-coenzyme A:cholesterol O-acyltransferase in macrophages, J. Biol. Chem., 273, 11218, 10.1074/jbc.273.18.11218
Kimmel, 2010, Adoption of PERILIPIN as a unifying nomenclature for the mammalian PAT-family of intracellular lipid storage droplet proteins, J. Lipid Res., 51, 468, 10.1194/jlr.R000034
Klemm, 2011, Dual role of ancient ubiquitous protein 1 (AUP1) in lipid droplet accumulation and endoplasmic reticulum (ER) protein quality control, J. Biol. Chem., 286, 37602, 10.1074/jbc.M111.284794
Kooijman, 2005, Spontaneous curvature of phosphatidic acid and lysophosphatidic acid, Biochemistry., 44, 2097, 10.1021/bi0478502
Krahmer, 2011, Phosphatidylcholine synthesis for lipid droplet expansion is mediated by localized activation of CTP:phosphocholine cytidylyltransferase, Cell Metab., 14, 504, 10.1016/j.cmet.2011.07.013
Krahmer, 2013, Balancing the fat: lipid droplets and human disease, EMBO Mol Med., 5, 905, 10.1002/emmm.201100671
Krause, 1984, Adipose tissue and cholesterol metabolism, J. Lipid Res., 25, 97, 10.1016/S0022-2275(20)37830-5
Kuerschner, 2008, Imaging of lipid biosynthesis: how a neutral lipid enters lipid droplets, Traffic., 9, 338, 10.1111/j.1600-0854.2007.00689.x
Kühnlein, 2012, Thematic review series: Lipid droplet synthesis and metabolism: from yeast to man. Lipid droplet-based storage fat metabolism in Drosophila, J. Lipid Res., 53, 1430, 10.1194/jlr.R024299
Lacey, 1999, The accumulation of triacylglycerols within the endoplasmic reticulum of developing seeds of Helianthus annuus, Plant J., 17, 397, 10.1046/j.1365-313X.1999.00387.x
Lands, 2000, Stories about acyl chains, Biochim. Biophys. Acta., 1483, 1, 10.1016/S1388-1981(99)00177-8
Liu, 2004, Chinese hamster ovary K2 cell lipid droplets appear to be metabolic organelles involved in membrane traffic, J. Biol. Chem., 279, 3787, 10.1074/jbc.M311945200
Long, 2012, Lipid droplet de novo formation and fission are linked to the cell cycle in fission yeast, Traffic., 13, 705, 10.1111/j.1600-0854.2012.01339.x
Mak, 2012, Lipid droplets as fat storage organelles in Caenorhabditis elegans: Thematic review series: Lipid droplet synthesis and metabolism: From yeast to man, J. Lipid Res., 53, 28, 10.1194/jlr.R021006
Malhotra, 2011, PKD regulates membrane fission to generate TGN to cell surface transport carriers, Cold Spring Harb. Perspect. Biol., 3, a005280, 10.1101/cshperspect.a005280
Marchesan, 2003, A phospholipase D-dependent process forms lipid droplets containing caveolin, adipocyte differentiation-related protein, and vimentin in a cell-free system, J. Biol. Chem., 278, 27293, 10.1074/jbc.M301430200
Martin, 2005, Regulated localization of Rab18 to lipid droplets: effects of lipolytic stimulation and inhibition of lipid droplet catabolism, J. Biol. Chem., 280, 42325, 10.1074/jbc.M506651200
McMahon, 2005, Membrane curvature and mechanisms of dynamic cell membrane remodelling, Nature., 438, 590, 10.1038/nature04396
Milewska, 2009, Identification of novel spartin-interactors shows spartin is a multifunctional protein, J. Neurochem., 111, 1022, 10.1111/j.1471-4159.2009.06382.x
Miranda, 2011, Re-patterning of skeletal muscle energy metabolism by fat storage-inducing transmembrane protein 2, J. Biol. Chem., 286, 42188, 10.1074/jbc.M111.297127
Moessinger, 2011, Human lysophosphatidylcholine acyltransferases 1 and 2 are located in lipid droplets where they catalyze the formation of phosphatidylcholine, J. Biol. Chem., 286, 21330, 10.1074/jbc.M110.202424
Mountford, 1988, Organization of lipids in the plasma membranes of malignant and stimulated cells: a new model, Trends Biochem. Sci., 13, 172, 10.1016/0968-0004(88)90145-4
Murphy, 1999, Mechanisms of lipid-body formation, Trends Biochem. Sci., 24, 109, 10.1016/S0968-0004(98)01349-8
Nakamura, 2003, Adipose differentiation-related protein has two independent domains for targeting to lipid droplets, Biochem. Biophys. Res. Commun., 306, 333, 10.1016/S0006-291X(03)00979-3
Novikoff, 1980, Organelle relationships in cultured 3T3-L1 preadipocytes, J. Cell Biol., 87, 180, 10.1083/jcb.87.1.180
Ohsaki, 2008, Lipid droplets are arrested in the ER membrane by tight binding of lipidated apolipoprotein B-100, J. Cell Sci., 121, 2415, 10.1242/jcs.025452
Ohsaki, 2009, Biogenesis of cytoplasmic lipid droplets: from the lipid ester globule in the membrane to the visible structure, Biochim. Biophys. Acta., 1791, 399, 10.1016/j.bbalip.2008.10.002
Ost, 2005, Triacylglycerol is synthesized in a specific subclass of caveolae in primary adipocytes, J. Biol. Chem., 280, 5, 10.1074/jbc.C400429200
Ozeki, 2005, Rab18 localizes to lipid droplets and induces their close apposition to the endoplasmic reticulum-derived membrane, J. Cell Sci., 118, 2601, 10.1242/jcs.02401
Park, 2010, Further assembly required: construction and dynamics of the endoplasmic reticulum network, EMBO Rep., 11, 515, 10.1038/embor.2010.92
Penno, 2013, Phospholipids and lipid droplets, Biochim. Biophys. Acta., 1831, 589, 10.1016/j.bbalip.2012.12.001
Ploegh, 2007, A lipid-based model for the creation of an escape hatch from the endoplasmic reticulum, Nature., 448, 435, 10.1038/nature06004
Pol, 2004, Dynamic and regulated association of caveolin with lipid bodies: modulation of lipid body motility and function by a dominant negative mutant, Mol. Biol. Cell., 15, 99, 10.1091/mbc.E03-06-0368
Poppelreuther, 2012, The N-terminal region of acyl-CoA synthetase 3 is essential for both the localization on lipid droplets and the function in fatty acid uptake, J. Lipid Res., 53, 888, 10.1194/jlr.M024562
Rajakumari, 2010, Janus-faced enzymes yeast Tgl3p and Tgl5p catalyze lipase and acyltransferase reactions, Mol. Biol. Cell., 21, 501, 10.1091/mbc.E09-09-0775
Rajakumari, 2010, Multiple functions as lipase, steryl ester hydrolase, phospholipase, and acyltransferase of Tgl4p from the yeast Saccharomyces cerevisiae, J. Biol. Chem., 285, 15769, 10.1074/jbc.M109.076331
Rao, 1966, Purification and properties of triglyceride synthetase from the intestinal mucosa, Biochim. Biophys. Acta., 125, 465, 10.1016/0005-2760(66)90035-X
Robenek, 2006, Adipophilin-enriched domains in the ER membrane are sites of lipid droplet biogenesis, J. Cell Sci., 119, 4215, 10.1242/jcs.03191
Roingeard, 2011, The birth and life of lipid droplets: learning from the hepatitis C virus, Biol. Cell., 103, 223, 10.1042/BC20100119
Saka, 2012, Emerging roles for lipid droplets in immunity and host-pathogen interactions, Annu. Rev. Cell Dev. Biol., 28, 411, 10.1146/annurev-cellbio-092910-153958
Sandoval, 2008, Fatty acid transport and activation and the expression patterns of genes involved in fatty acid trafficking, Arch. Biochem. Biophys., 477, 363, 10.1016/j.abb.2008.06.010
Sato, 2006, Proteomic profiling of lipid droplet proteins in hepatoma cell lines expressing hepatitis C virus core protein, J. Biochem., 139, 921, 10.1093/jb/mvj104
Sembongi, 2013, Distinct roles of the phosphatidate phosphatases lipin 1 and 2 during adipogenesis and lipid droplet biogenesis in 3T3-L1 cells, J. Biol. Chem., 288, 34502, 10.1074/jbc.M113.488445
Siniossoglou, 2013, Phospholipid metabolism and nuclear function: roles of the lipin family of phosphatidic acid phosphatases, Biochim. Biophys. Acta., 1831, 575, 10.1016/j.bbalip.2012.09.014
Skinner, 2009, Diacylglycerol enrichment of endoplasmic reticulum or lipid droplets recruits perilipin 3/TIP47 during lipid storage and mobilization, J. Biol. Chem., 284, 30941, 10.1074/jbc.M109.013995
Spandl, 2011, Ancient ubiquitous protein 1 (AUP1) localizes to lipid droplets and binds the E2 ubiquitin conjugase G2 (Ube2g2) via its G2 binding region, J. Biol. Chem., 286, 5599, 10.1074/jbc.M110.190785
Stehr, 2012, Cytosolic lipid inclusions formed during infection by viral and bacterial pathogens, Microbes Infect., 14, 1227, 10.1016/j.micinf.2012.08.001
Stevanovic, 2013, Monotopic topology is required for lipid droplet targeting of ancient ubiquitous protein 1, J. Lipid Res., 54, 503, 10.1194/jlr.M033852
Stone, 2009, The endoplasmic reticulum enzyme DGAT2 is found in mitochondria-associated membranes and has a mitochondrial targeting signal that promotes its association with mitochondria, J. Biol. Chem., 284, 5352, 10.1074/jbc.M805768200
Sturley, 2012, Lipid droplet formation on opposing sides of the endoplasmic reticulum, J. Lipid Res., 53, 1800, 10.1194/jlr.R028290
Suzuki, 2011, Lipid droplets: size matters, J. Electron Microsc. (Tokyo)., 60, S101, 10.1093/jmicro/dfr016
Suzuki, 2013, Protein kinase Cη is targeted to lipid droplets, Histochem. Cell Biol., 139, 505, 10.1007/s00418-013-1083-z
Suzuki, 2005, Molecular determinants for subcellular localization of hepatitis C virus core protein, J. Virol., 79, 1271, 10.1128/JVI.79.2.1271-1281.2005
Sztalryd, 2006, Functional compensation for adipose differentiation-related protein (ADFP) by Tip47 in an ADFP null embryonic cell line, J. Biol. Chem., 281, 34341, 10.1074/jbc.M602497200
Szymanski, 2007, The lipodystrophy protein seipin is found at endoplasmic reticulum lipid droplet junctions and is important for droplet morphology, Proc. Natl. Acad. Sci. USA., 104, 20890, 10.1073/pnas.0704154104
Tauchi-Sato, 2002, The surface of lipid droplets is a phospholipid monolayer with a unique Fatty Acid composition, J. Biol. Chem., 277, 44507, 10.1074/jbc.M207712200
Tomoda, 1987, Inhibition of acyl-CoA synthetase by triacsins, Biochim. Biophys. Acta., 921, 595, 10.1016/0005-2760(87)90088-9
Vallet-Pichard, 2012, Nonalcoholic fatty liver disease and HIV infection, Semin. Liver Dis., 32, 158, 10.1055/s-0032-1316471
van den Bosch, 1997, Alkyl-dihydroxyacetonephosphate synthase, Biochim. Biophys. Acta., 1348, 35, 10.1016/S0005-2760(97)00107-0
Vance, 2009, Physiological consequences of disruption of mammalian phospholipid biosynthetic genes, J. Lipid Res., 50, S132, 10.1194/jlr.R800048-JLR200
Vance, 2004, Phospholipid biosynthesis in mammalian cells, Biochem. Cell Biol., 82, 113, 10.1139/o03-073
Walther, 2009, The life of lipid droplets, Biochim. Biophys. Acta., 1791, 459, 10.1016/j.bbalip.2008.10.009
Walther, 2012, Lipid droplets and cellular lipid metabolism, Annu. Rev. Biochem., 81, 687, 10.1146/annurev-biochem-061009-102430
Wang, 2012, The ubiquitin-like (UBX)-domain-containing protein Ubx2/Ubxd8 regulates lipid droplet homeostasis, J. Cell Sci., 125, 2930, 10.1242/jcs.100230
Wang, 2011, Lipin-1γ isoform is a novel lipid droplet-associated protein highly expressed in the brain, FEBS Lett., 585, 1979, 10.1016/j.febslet.2011.05.035
Wanner, 1981, The ontogeny of lipid bodies (spherosomes) in plant cells: Ultrastructural evidence, Planta., 151, 109, 10.1007/BF00387812
Watkins, 2007, Evidence for 26 distinct acyl-coenzyme A synthetase genes in the human genome, J. Lipid Res., 48, 2736, 10.1194/jlr.M700378-JLR200
Welte, 2009, Fat on the move: intracellular motion of lipid droplets, Biochem. Soc. Trans., 37, 991, 10.1042/BST0370991
Wilfling, 2013, Triacylglycerol synthesis enzymes mediate lipid droplet growth by relocalizing from the ER to lipid droplets, Dev. Cell., 24, 384, 10.1016/j.devcel.2013.01.013
Wolins, 2006, A proposed model of fat packaging by exchangeable lipid droplet proteins, FEBS Lett., 580, 5484, 10.1016/j.febslet.2006.08.040
Xu, 2012, The FATP1-DGAT2 complex facilitates lipid droplet expansion at the ER-lipid droplet interface, J. Cell Biol., 198, 895, 10.1083/jcb.201201139
Yang, 2011, COPI acts in both vesicular and tubular transport, Nat. Cell Biol., 13, 996, 10.1038/ncb2273
Yang, 2012, The proteomics of lipid droplets: structure, dynamics, and functions of the organelle conserved from bacteria to humans, J. Lipid Res., 53, 1245, 10.1194/jlr.R024117
Zanghellini, 2010, Phospholipid demixing and the birth of a lipid droplet, J. Theor. Biol., 264, 952, 10.1016/j.jtbi.2010.02.025
Zechner, 2012, FAT SIGNALS—lipases and lipolysis in lipid metabolism and signaling, Cell Metab., 15, 279, 10.1016/j.cmet.2011.12.018