Biochemical Pathways of Caspase Activation During Apoptosis

Annual Review of Cell and Developmental Biology - Tập 15 Số 1 - Trang 269-290 - 1999
Imawati Budihardjo1, George R. Oliver1, Michael Lutter1, Xu Luo1, Xiaodong Wang1
1Howard Hughes Medical Institute and Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, Texas 75235;

Tóm tắt

▪ Abstract  Caspase activation plays a central role in the execution of apoptosis. The key components of the biochemical pathways of caspase activation have been recently elucidated. In this review, we focus on the two most well-studied pathways of caspase activation: the cell surface death receptor pathway and the mitochondria-initiated pathway. In the cell surface death receptor pathway, activation of caspase-8 following its recruitment to the death-inducing signaling complex (DISC) is the critical event that transmits the death signal. This event is regulated at several different levels by various viral and mammalian proteins. Activated caspase-8 can activate downstream caspases by direct cleavage or indirectly by cleaving Bid and inducing cytochrome c release from the mitochondria. In the mitochondrial-initiated pathway, caspase activation is triggered by the formation of a multimeric Apaf-1/cytochrome c complex that is fully functional in recruiting and activating procaspase-9. Activated caspase-9 will then cleave and activate downstream caspases such as caspase-3, -6, and -7. This pathway is regulated at several steps, including the release of cytochrome c from the mitochondria, the binding and hydrolysis of dATP/ATP by Apaf-1, and the inhibition of caspase activation by the proteins that belong to the inhibitors of apoptosis (IAP).

Từ khóa


Tài liệu tham khảo

10.1126/science.281.5381.1322

Ahmad M, 1998, Cancer Res., 58, 5201

10.1038/nm0897-917

10.1126/science.277.5324.370

10.1126/science.281.5381.1305

10.1073/pnas.92.18.8373

10.1101/gad.12.9.1304

10.1016/0140-6736(92)92826-2

10.1016/S0092-8674(00)81265-9

10.1074/jbc.270.14.7795

10.1093/emboj/17.1.37

10.1182/blood.V62.4.737.737

10.1016/S0092-8674(00)81732-8

Centola M, Chen X, Sood R, Deng Z, Aksentijevich I, et al. 1998. GenBank Accession No. AF098666

10.1074/jbc.273.18.10815

10.1006/dbio.1998.9000

10.1016/0092-8674(95)90071-3

10.1073/pnas.94.19.10057

10.1073/pnas.75.1.472

10.1016/S0092-8674(00)81182-4

10.1016/S0960-9822(06)00410-6

10.1046/j.1432-1327.1998.2580729.x

10.1101/gad.12.11.1551

10.1093/emboj/17.8.2215

10.1038/40901

10.1073/pnas.96.8.4307

10.1002/j.1460-2075.1996.tb00629.x

10.1146/annurev.cb.07.110191.003311

10.1093/emboj/16.20.6192

10.1182/blood.V92.4.1235

10.1016/0006-2952(85)90734-8

10.1016/S0960-9822(06)00395-2

10.1074/jbc.272.32.19641

10.1074/jbc.274.2.1156

10.1016/S0092-8674(00)81477-4

10.1073/pnas.94.21.11333

10.1128/MCB.16.10.5857

10.1016/S0968-0004(97)01043-8

10.1074/jbc.273.45.29648

10.1074/jbc.272.28.17255

10.1074/jbc.273.50.33489

10.1074/jbc.273.25.15702

10.1093/emboj/16.7.1686

10.1074/jbc.273.49.32479

10.1073/pnas.94.20.10717

10.1038/40657

10.1126/science.283.5401.543

10.1073/pnas.95.9.4997

10.1182/blood.V81.3.597.597

10.1038/bjc.1972.33

10.1126/science.275.5303.1132

Komiyama T, 1994, J. Biol. Chem., 269, 19331, 10.1016/S0021-9258(17)32171-3

10.1016/S0167-5699(97)80014-X

10.1016/S0092-8674(00)81476-2

10.1126/science.7535475

10.1038/384368a0

10.1074/jbc.273.26.16589

10.1073/pnas.95.16.9567

10.1016/S0092-8674(00)81590-1

10.1016/0092-8674(95)90490-5

10.1016/S0092-8674(00)80434-1

10.1038/379349a0

10.1016/S0092-8674(00)80085-9

10.1016/S0092-8674(00)81589-5

10.1084/jem.184.3.1155

10.1016/S0960-9822(06)00422-2

10.1074/jbc.273.8.4345

10.1126/science.281.5385.2027

10.1084/jem.187.8.1261

10.1093/emboj/16.10.2794

10.1038/385353a0

10.1038/381335a0

10.1016/S0092-8674(00)81266-0

10.1074/jbc.273.5.2926

10.1016/S0092-8674(00)81874-7

10.1073/pnas.95.25.14681

10.1093/emboj/17.2.384

10.1074/jbc.273.10.5841

10.1002/(SICI)1097-4644(19960101)60:1<12::AID-JCB3>3.0.CO;2-6

10.1074/jbc.273.13.7770

10.1038/25387

10.1016/0092-8674(92)90223-Y

10.1038/35160

10.1093/emboj/16.23.6914

10.1093/emboj/17.6.1675

10.1073/pnas.94.10.5113

10.1073/pnas.94.21.11357

10.1085/jgp.112.3.317

10.1016/S0960-9822(06)00216-8

10.1073/pnas.94.25.13606

10.1074/jbc.273.52.35109

10.1073/pnas.95.4.1455

10.1126/science.275.5299.536

10.1016/S1097-2765(00)80095-7

10.1073/pnas.93.25.14486

10.1074/jbc.272.30.18542

10.1126/science.7878463

10.1074/jbc.273.14.7787

10.1038/386517a0

10.1126/science.281.5381.1312

10.1016/S0092-8674(00)80450-X

10.1016/S1074-7613(00)80609-3

10.1128/MCB.18.10.6083

10.1101/gad.10.22.2859

10.1016/S0092-8674(00)80943-5

10.1126/science.275.5303.1129

10.1016/S1097-2765(00)80032-5

10.1016/S0092-8674(00)81733-X

10.1084/jem.183.4.1533

10.1016/S0092-8674(00)81382-3

10.1016/S0092-8674(00)80501-2

10.1074/jbc.274.17.11549

Thông tin
Thông tin xuất bản

Annual Review of Cell and Developmental Biology

Tập 15 Số 1

269-290

Thông tin tác giả